{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T05:55:10Z","timestamp":1790661310501,"version":"4.1.0"},"reference-count":24,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2013,9,17]],"date-time":"2013-09-17T00:00:00Z","timestamp":1379376000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Journal of Dermatology"],"published-print":{"date-parts":[[2013,11]]},"abstract":"Abstract<\/jats:title>Serum thymus and activation\u2010regulated chemokine\/CCL<\/jats:styled-content>17 (sTARC<\/jats:styled-content>) is known as a good indicator for atopic dermatitis severity. Herein, we investigate whether sTARC<\/jats:styled-content> correlates with severity and therapeutic response for alopecia areata (AA<\/jats:styled-content>) in our 121 patients. The sTARC<\/jats:styled-content> mean of AA<\/jats:styled-content> totalis and universalis was significantly higher than mild AA<\/jats:styled-content>. Next, we compared sTARC<\/jats:styled-content> of diffuse AA<\/jats:styled-content> (n<\/jats:italic>\u00a0=\u00a014) and severity\u2010controlled patchy AA<\/jats:styled-content> (n<\/jats:italic>\u00a0=\u00a032) and found that sTARC<\/jats:styled-content> in diffuse AA<\/jats:styled-content> (564.2\u00a0\u00b1\u00a0400.0\u00a0pg\/mL) was significantly higher than that of the patchy type (344.0\u00a0\u00b1\u00a0239.8\u00a0pg\/mL), suggesting a potential role of TARC<\/jats:styled-content> in active progression of diffuse AA<\/jats:styled-content>. Ten patients with diffuse AA<\/jats:styled-content> were treated with i.v. corticosteroid pulse therapy. Then, we tested whether sTARC<\/jats:styled-content> can predict prognosis after the pulse therapy and found that baseline sTARC<\/jats:styled-content> in the poor responders (1025.5\u00a0\u00b1\u00a0484.8\u00a0pg\/mL) was significantly higher than that in the good responders (complete remission at 24 months after the pulse therapy, 347.8\u00a0\u00b1\u00a0135.7\u00a0pg\/mL), indicating sTARC<\/jats:styled-content> as a response biomarker in the corticosteroid pulse therapy for diffuse AA<\/jats:styled-content>. Finally, to investigate TARC<\/jats:styled-content> production in the affected hair follicles, we performed immunohistochemical double staining of TARC<\/jats:styled-content> and CD<\/jats:styled-content>68 using scalp skin specimens of diffuse AA<\/jats:styled-content> with high titers of sTARC<\/jats:styled-content>. The results showed their co\u2010localization in the infiltrating cells around the AA<\/jats:styled-content> hair follicles, suggesting that TARC<\/jats:styled-content> is mainly produced from CD<\/jats:styled-content>68+<\/jats:sup> histiocytes. In conclusion, sTARC<\/jats:styled-content> is a disease activity and response biomarker in AA<\/jats:styled-content>, providing new insight beyond the T<\/jats:styled-content>\u2010helper 1\/2 paradigm to solve the immunological pathogenesis of AA<\/jats:styled-content>.<\/jats:p>","DOI":"10.1111\/1346-8138.12273","type":"journal-article","created":{"date-parts":[[2013,10,8]],"date-time":"2013-10-08T16:59:32Z","timestamp":1381251572000},"page":"881-885","source":"Crossref","is-referenced-by-count":31,"title":["Serum thymus and activation\u2010regulated chemokine as disease activity and response biomarker in alopecia areata"],"prefix":"10.1111","volume":"40","author":[{"given":"Shigeki","family":"Inui","sequence":"first","affiliation":[{"name":"Department of Regenerative Dermatology Osaka University Graduate School of Medicine Suita Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fumihito","family":"Noguchi","sequence":"additional","affiliation":[{"name":"Department of Regenerative Dermatology Osaka University Graduate School of Medicine Suita Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takeshi","family":"Nakajima","sequence":"additional","affiliation":[{"name":"Department of Regenerative Dermatology Osaka University Graduate School of Medicine Suita Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satoshi","family":"Itami","sequence":"additional","affiliation":[{"name":"Department of Regenerative Dermatology Osaka University Graduate School of Medicine Suita 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