{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T05:51:09Z","timestamp":1761630669692},"reference-count":16,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2013,12,4]],"date-time":"2013-12-04T00:00:00Z","timestamp":1386115200000},"content-version":"vor","delay-in-days":3,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Journal of Dermatology"],"published-print":{"date-parts":[[2013,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Cutaneous arteritis (cutaneous polyarteritis nodosa, <jats:styled-content style=\"fixed-case\">CA<\/jats:styled-content>) is a necrotizing vasculitis of arteries within the skin. <jats:styled-content style=\"fixed-case\">CA<\/jats:styled-content> is a new classification under single\u2010organ vasculitis, as adopted by the 2012 Chapel Hill consensus conference (<jats:styled-content style=\"fixed-case\">CHCC<\/jats:styled-content> 2012). Some patients originally diagnosed as having <jats:styled-content style=\"fixed-case\">CA<\/jats:styled-content> could develop additional disease manifestations that warrant reclassifying as systemic polyarteritis nodosa (<jats:styled-content style=\"fixed-case\">PAN<\/jats:styled-content>) according to the <jats:styled-content style=\"fixed-case\">CHCC<\/jats:styled-content> 2012. We retrospectively investigated 101 patients with <jats:styled-content style=\"fixed-case\">CA<\/jats:styled-content> seen at our department between 2003 and 2012. There was a significantly higher frequency of inflammatory plaques and leg edema in <jats:styled-content style=\"fixed-case\">CA<\/jats:styled-content> patients with elevated C\u2010reactive protein (<jats:styled-content style=\"fixed-case\">CRP<\/jats:styled-content>) compared to <jats:styled-content style=\"fixed-case\">CA<\/jats:styled-content> patients with normal <jats:styled-content style=\"fixed-case\">CRP<\/jats:styled-content>. Similarly, there were significant differences in the incidence of arthralgia and mononeuritis multiplex between the two patient groups. We found significantly positive correlations between <jats:styled-content style=\"fixed-case\">CRP<\/jats:styled-content> and creatinine titers in serum in all 101 <jats:styled-content style=\"fixed-case\">CA<\/jats:styled-content> patients. Prednisolone was administrated in a significantly greater percentage of patients with elevated <jats:styled-content style=\"fixed-case\">CRP<\/jats:styled-content> compared to patients with normal <jats:styled-content style=\"fixed-case\">CRP<\/jats:styled-content>. Repeated i.v. cyclophosphamide pulse therapy (<jats:styled-content style=\"fixed-case\">IV<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">CY<\/jats:styled-content>) with prednisolone therapy at an early stage resulted in complete resolution without adverse effects or severe complications. We regard inflammatory plaques and leg edema with elevated serum <jats:styled-content style=\"fixed-case\">CRP<\/jats:styled-content> as an indication of a more severe condition, and treated them effectively with prednisolone. Assuming mononeuritis multiplex and\/or arthritis exist with elevated <jats:styled-content style=\"fixed-case\">CRP<\/jats:styled-content>, we propose that earlier treatment by <jats:styled-content style=\"fixed-case\">IV<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">CY<\/jats:styled-content> with prednisolone should be indicated for <jats:styled-content style=\"fixed-case\">CA<\/jats:styled-content> patients who demonstrate these more severe manifestations to prevent progression to <jats:styled-content style=\"fixed-case\">PAN<\/jats:styled-content>.<\/jats:p>","DOI":"10.1111\/1346-8138.12303","type":"journal-article","created":{"date-parts":[[2013,12,4]],"date-time":"2013-12-04T13:10:21Z","timestamp":1386162621000},"page":"955-961","source":"Crossref","is-referenced-by-count":13,"title":["Treatment for cutaneous arteritis patients with mononeuritis multiplex and elevated <scp>C<\/scp>\u2010reactive protein"],"prefix":"10.1111","volume":"40","author":[{"given":"Tamihiro","family":"Kawakami","sequence":"first","affiliation":[{"name":"Department of Dermatology St Marianna University School of Medicine Kawasaki Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Azusa","family":"Okudaira","sequence":"additional","affiliation":[{"name":"Department of Dermatology St Marianna University School of Medicine Kawasaki Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tatsuro","family":"Okano","sequence":"additional","affiliation":[{"name":"Department of Dermatology St Marianna University School of Medicine Kawasaki Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sora","family":"Takeuchi","sequence":"additional","affiliation":[{"name":"Department of Dermatology St Marianna University School of Medicine Kawasaki Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Satoko","family":"Kimura","sequence":"additional","affiliation":[{"name":"Department of Dermatology St Marianna University School of Medicine Kawasaki Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshinao","family":"Soma","sequence":"additional","affiliation":[{"name":"Department of Dermatology St Marianna University School of Medicine Kawasaki Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akihiro","family":"Ishizu","sequence":"additional","affiliation":[{"name":"Department of Pathology\/Pathophysiology Division of Pathophysiological Science Hokkaido University Graduate School of Medicine Sapporo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshihiro","family":"Arimura","sequence":"additional","affiliation":[{"name":"First Department of Internal Medicine Kyorin University School of Medicine Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shigeto","family":"Kobayashi","sequence":"additional","affiliation":[{"name":"Department of Rheumatology Juntendo Koshigaya Hospital Saitama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shoichi","family":"Ozaki","sequence":"additional","affiliation":[{"name":"Division of Rheumatology and Allergology Department of Internal Medicine St Marianna University School of Medicine Kawasaki 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