{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,10]],"date-time":"2026-01-10T18:39:00Z","timestamp":1768070340458,"version":"3.49.0"},"reference-count":18,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2013,12,20]],"date-time":"2013-12-20T00:00:00Z","timestamp":1387497600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Journal of Dermatology"],"published-print":{"date-parts":[[2014,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>A multisite, open\u2010label, non\u2010randomized, single\u2010arm phase <jats:styled-content style=\"fixed-case\">II<\/jats:styled-content> study was conducted to evaluate the efficacy and safety profiles of interferon\u2010\u03b3 in <jats:styled-content style=\"fixed-case\">J<\/jats:styled-content>apanese patients diagnosed with stage <jats:styled-content style=\"fixed-case\">IA<\/jats:styled-content>\u2013<jats:styled-content style=\"fixed-case\">IIIA<\/jats:styled-content> mycosis fungoides (<jats:styled-content style=\"fixed-case\">MF<\/jats:styled-content>). Interferon\u2010\u03b3 was administrated i.v. to 15 patients at a dose of 2\u00a0million Japan reference units once daily over 5\u00a0days a week for the first 4\u00a0weeks, followed by subsequent intermittent injection. The primary efficacy end\u2010point was the overall skin response during the study as assessed according to the evaluation criteria for chemotherapeutics for malignant skin carcinomas. Of the 15 patients, 11 (73.3%) achieved the objective response. Of the other four patients, three remained on treatment during study with stable disease and one showed disease progression. The median duration of stable disease was not reached but was 170\u00a0days or more (range, 29 to \u2265253\u00a0days). As assessed according to the modified severity weighted assessment tool, nine patients (60.0%) achieved the objective response. The most common drug\u2010related adverse event (AE) was influenza\u2010like illness occurring in all patients enrolled, which did not lead to discontinuation of the study. Two serious AE were reported in two patients: aggravation of <jats:styled-content style=\"fixed-case\">MF<\/jats:styled-content> and aggravation of cataract, neither of which was considered directly related to the study drug. The patient with aggravation of <jats:styled-content style=\"fixed-case\">MF<\/jats:styled-content> died 50\u00a0days after the initiation of the study treatment. Another patient was withdrawn from the study due to drug\u2010related cough, which disappeared after discontinuation of the drug. Overall, interferon\u2010\u03b3 was effective and well\u2010tolerated in <jats:styled-content style=\"fixed-case\">J<\/jats:styled-content>apanese patients with <jats:styled-content style=\"fixed-case\">MF<\/jats:styled-content>.<\/jats:p>","DOI":"10.1111\/1346-8138.12341","type":"journal-article","created":{"date-parts":[[2013,12,20]],"date-time":"2013-12-20T06:26:58Z","timestamp":1387520818000},"page":"50-56","source":"Crossref","is-referenced-by-count":39,"title":["Phase <scp>II<\/scp> study of i.v. interferon\u2010gamma in <scp>J<\/scp>apanese patients with mycosis fungoides"],"prefix":"10.1111","volume":"41","author":[{"given":"Makoto","family":"Sugaya","sequence":"first","affiliation":[{"name":"Department of Dermatology Faculty of Medicine University of Tokyo Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshiki","family":"Tokura","sequence":"additional","affiliation":[{"name":"Department of Dermatology Hamamatsu University School of Medicine 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