{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,12]],"date-time":"2026-06-12T11:41:09Z","timestamp":1781264469983,"version":"3.54.1"},"reference-count":6,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2014,2,24]],"date-time":"2014-02-24T00:00:00Z","timestamp":1393200000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Journal of Dermatology"],"published-print":{"date-parts":[[2014,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Phototoxic reaction has not been reported previously as an adverse reaction to the combination of atovaquone and proguanil (<jats:styled-content style=\"fixed-case\">AP<\/jats:styled-content>) (<jats:styled-content style=\"fixed-case\">M<\/jats:styled-content>alarone) used for antimalarial prophylaxis and therapy. We report here a 32\u2010year\u2010old patient treated with <jats:styled-content style=\"fixed-case\">AP<\/jats:styled-content> who presented with clinical manifestations of photosensitivity. <jats:styled-content style=\"fixed-case\">AP<\/jats:styled-content>\u2010induced phototoxicity in this patient was further supported by phototesting. Malarone is not known to photosensitize and render the skin more susceptible to severe sunburn\u2010like reactions. That it may do so, as in this case, is of importance especially as this drug is used predominantly by those travelling to sunnier climes. A notification of potential phototoxic effects of <jats:styled-content style=\"fixed-case\">AP<\/jats:styled-content> should be published for the choice of prophylaxis made by tourists traveling in malarial areas.<\/jats:p>","DOI":"10.1111\/1346-8138.12368","type":"journal-article","created":{"date-parts":[[2014,2,24]],"date-time":"2014-02-24T18:23:18Z","timestamp":1393266198000},"page":"346-348","source":"Crossref","is-referenced-by-count":7,"title":["Phototoxic reaction associated with <scp>M<\/scp>alarone (atovaquone\/proguanil) antimalarial prophylaxis"],"prefix":"10.1111","volume":"41","author":[{"given":"Aymeric","family":"Amelot","sequence":"first","affiliation":[{"name":"Department of Photodermatology St Louis Hospital University of Paris Descartes Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean","family":"Dupouy\u2010Camet","sequence":"additional","affiliation":[{"name":"Department of Parasitology and Mycology Cochin Hospital University of Paris Descartes Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michel","family":"Jeanmougin","sequence":"additional","affiliation":[{"name":"Department of Photodermatology St Louis Hospital University of Paris Descartes Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,2,24]]},"reference":[{"key":"e_1_2_4_2_1","doi-asserted-by":"publisher","DOI":"10.1201\/b14463"},{"key":"e_1_2_4_3_1","first-page":"278","article-title":"Drug eruptions: approaching the diagnosis of drug\u2010induced skin diseases","volume":"2","author":"Nigen S","year":"2003","journal-title":"J Drugs Dermatol"},{"key":"e_1_2_4_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/0190-9622(95)91271-1"},{"key":"e_1_2_4_5_1","doi-asserted-by":"publisher","DOI":"10.1562\/0031-8655(1999)069<0282:PSOAD>2.3.CO;2"},{"key":"e_1_2_4_6_1","doi-asserted-by":"publisher","DOI":"10.1086\/375073"},{"key":"e_1_2_4_7_1","doi-asserted-by":"publisher","DOI":"10.1517\/14740338.6.4.431"}],"container-title":["The Journal of Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2F1346-8138.12368","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1346-8138.12368","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,24]],"date-time":"2023-09-24T16:14:32Z","timestamp":1695572072000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/1346-8138.12368"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,2,24]]},"references-count":6,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2014,4]]}},"alternative-id":["10.1111\/1346-8138.12368"],"URL":"https:\/\/doi.org\/10.1111\/1346-8138.12368","archive":["Portico"],"relation":{},"ISSN":["0385-2407","1346-8138"],"issn-type":[{"value":"0385-2407","type":"print"},{"value":"1346-8138","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,2,24]]}}}