{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T15:44:27Z","timestamp":1759333467726},"reference-count":9,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2014,1,18]],"date-time":"2014-01-18T00:00:00Z","timestamp":1390003200000},"content-version":"vor","delay-in-days":17,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Journal of Dermatology"],"published-print":{"date-parts":[[2014,1]]},"abstract":"Abstract<\/jats:title>From a clinicopathological conference on nine elderly patients with Epstein\u2013Barr virus (EBV<\/jats:styled-content>)\u2010associated T\/natural killer (NK<\/jats:styled-content>)\u2010cell lymphoma, we have addressed the patients' backgrounds, clinical manifestations, histopathological findings, cytogenesis, complications and prognoses. Among these elderly patients (>65\u00a0years old), seven patients had extranodal NK<\/jats:styled-content>\/T<\/jats:styled-content>\u2010cell lymphoma, nasal type (ENKL<\/jats:styled-content>) with an NK<\/jats:styled-content>\u2010cell phenotype, and two patients had EBV<\/jats:styled-content>+<\/jats:sup> T\u2010cell lymphomas or lymphoproliferative disorders (LPD<\/jats:styled-content>) with cutaneous lesions mimicking pityriasis lichenoides et varioliformis acuta (PLEVA<\/jats:styled-content>) or hydroa vacciniforme (HV<\/jats:styled-content>). No patients had a previous episode of EBV<\/jats:styled-content>\u2010related symptoms such as infectious mononucleosis, chronic active EBV<\/jats:styled-content> infection, HV<\/jats:styled-content> or hypersensitivity to mosquito bites. Elderly patients with ENKL<\/jats:styled-content> may show the centroblastoid variant. EBV<\/jats:styled-content>+<\/jats:sup>CD<\/jats:styled-content>8+<\/jats:sup>CD<\/jats:styled-content>56+\/\u2212<\/jats:sup> lymphocytes may be responsible for the development of PLEVA<\/jats:styled-content> or HV<\/jats:styled-content>\u2010like cutaneous lesions in the elderly.<\/jats:p>","DOI":"10.1111\/1346-8138.12373","type":"journal-article","created":{"date-parts":[[2014,1,18]],"date-time":"2014-01-18T13:16:47Z","timestamp":1390051007000},"page":"40-42","source":"Crossref","is-referenced-by-count":9,"title":["Epstein\u2013Barr virus\u2010associated T<\/scp>\/natural killer\u2010cell lymphomas in the elderly: The first consensus meeting in Kofu 2013"],"prefix":"10.1111","volume":"41","author":[{"given":"Toshihisa","family":"Hamada","sequence":"first","affiliation":[{"name":"Department of Dermatology Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences Okayama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shigeo","family":"Nakamura","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine Nagoya University Hospital Nagoya Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Young\u2010Hyeh","family":"Ko","sequence":"additional","affiliation":[{"name":"Department of Pathology Samsung Medical Center Sungkyunkwan University Seoul Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tadashi","family":"Yoshino","sequence":"additional","affiliation":[{"name":"Department of Pathology Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences Okayama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Koichi","family":"Ohshima","sequence":"additional","affiliation":[{"name":"Department of Pathology School of Medicine Kurume University Kurume Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takamitsu","family":"Matsuzawa","sequence":"additional","affiliation":[{"name":"Department of Dermatology Faculty of Medicine University of Yamanashi Yamanashi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keiko","family":"Miura","sequence":"additional","affiliation":[{"name":"Department of Diagnostic Pathology Medical Hospital of Tokyo Medical and Dental University Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toshifumi","family":"Takahashi","sequence":"additional","affiliation":[{"name":"Department of Dermatology Shiga University of Medical Science Shiga Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hisashi","family":"Nomura","sequence":"additional","affiliation":[{"name":"Department of Dermatology Shizuoka Municipal Shimizu Hospital Shizuoka 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School of Medicine, Dentistry and Pharmaceutical Sciences Okayama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,1,18]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1827.2008.02213.x"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1086\/427239"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12308-012-0169-1"},{"key":"e_1_2_7_5_1","article-title":"An elderly patient of chronic active Epstein\u2010Barr virus infection with severe hydroa vacciniforme \u2010like eruptions associated with \u03b1\u03b2T cell proliferation","author":"Nomura H","journal-title":"J Dermatol"},{"key":"e_1_2_7_6_1","article-title":"Extranodal NK\/T\u2010cell lymphoma, nasal type, with prominent granulomatous reaction","author":"Fujimoto N","journal-title":"J Dermatol"},{"key":"e_1_2_7_7_1","first-page":"285","volume-title":"WHO Classification of Tumours of 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