{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,20]],"date-time":"2025-12-20T22:03:11Z","timestamp":1766268191258},"reference-count":7,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2014,1,18]],"date-time":"2014-01-18T00:00:00Z","timestamp":1390003200000},"content-version":"vor","delay-in-days":17,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Journal of Dermatology"],"published-print":{"date-parts":[[2014,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Based on the advances in research on the clinicopathophysiology of adult T\u2010cell leukemia\u2010lymphoma (<jats:styled-content style=\"fixed-case\">ATL<\/jats:styled-content>), Japanese researchers collected and evaluated cases of smoldering <jats:styled-content style=\"fixed-case\">ATL<\/jats:styled-content> exhibiting primary cutaneous manifestation but showing poor prognosis. Macroscopic findings of skin eruptions were categorized into the patch, plaque, multipapular, nodulotumoral, erythrodermic and purpuric types, as previously reported. Pathological findings were divided into low or high grade based on epidermotropism, tumor cell size and perivascular infiltration. Eight eligible cases were evaluated among 14 collected cases. Macroscopic findings were nodulotumoral in six cases, a subcutaneous tumor in one case and plaque in one case, and the number and size were heterogeneous in each case. Pathological findings of all eight cases were T\u2010cell lymphoma, high\u2010grade type (pleomorphic, medium or large size), with prominent perivascular infiltration and scant epidermotropism. To diagnose such cases as the \u201clymphoma type of <jats:styled-content style=\"fixed-case\">ATL<\/jats:styled-content>, extranodal primary cutaneous variant\u201d, it is essential to examine each case carefully, including cutaneous lesions at onset, lymph nodes and other organ involvement using computed tomography (<jats:styled-content style=\"fixed-case\">CT<\/jats:styled-content>) and\/or positron emission tomography\/<jats:styled-content style=\"fixed-case\">CT<\/jats:styled-content>, as well as the percentage of abnormal lymphocytes in peripheral blood. Based on the results of an ongoing nationwide survey on <jats:styled-content style=\"fixed-case\">ATL<\/jats:styled-content>,<jats:styled-content style=\"fixed-case\"> ATL<\/jats:styled-content> with cutaneous lesions will be analyzed to investigate the incidence and prognosis of the so\u2010called \u201clymphoma type of <jats:styled-content style=\"fixed-case\">ATL<\/jats:styled-content>, extranodal primary cutaneous variant\u201d.<\/jats:p>","DOI":"10.1111\/1346-8138.12374","type":"journal-article","created":{"date-parts":[[2014,1,18]],"date-time":"2014-01-18T13:16:47Z","timestamp":1390051007000},"page":"26-28","source":"Crossref","is-referenced-by-count":27,"title":["Meeting report on the possible proposal of an extranodal primary cutaneous variant in the lymphoma type of adult T\u2010cell leukemia\u2010lymphoma"],"prefix":"10.1111","volume":"41","author":[{"given":"Kunihiro","family":"Tsukasaki","sequence":"first","affiliation":[{"name":"Department of Hematology National Cancer Center Hospital East Kashiwa Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yositaka","family":"Imaizumi","sequence":"additional","affiliation":[{"name":"Department of Hematology Atomic Bomb Disease and Hibakusha Medicine Unit, Atomic Bomb Disease Institute Nagasaki University Nagasaki Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshiki","family":"Tokura","sequence":"additional","affiliation":[{"name":"Department of Dermatology Hamamatsu University School of Medicine Hamamatsu Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kouichi","family":"Ohshima","sequence":"additional","affiliation":[{"name":"Department of Pathology Kurume University Kurume Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazuhiro","family":"Kawai","sequence":"additional","affiliation":[{"name":"Department of Dermatology Kido Hospital Niigata Japan"},{"name":"Department of Dermatology Kagoshima University Graduate School of Medical and Dental Sciences Kagoshima Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Atae","family":"Utsunomiya","sequence":"additional","affiliation":[{"name":"Department of Hematology Imamura Bun\u2010in Hospital Kagoshima Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masahiro","family":"Amano","sequence":"additional","affiliation":[{"name":"Department of Dermatology Miyazaki University Miyazaki Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toshiki","family":"Watanabe","sequence":"additional","affiliation":[{"name":"Graduate School of Frontier Sciences The University of Tokyo Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shigeo","family":"Nakamura","sequence":"additional","affiliation":[{"name":"Pathology and Laboratory Medicine Nagoya University Hospital Nagoya Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keiji","family":"Iwatsuki","sequence":"additional","affiliation":[{"name":"Department of Dermatology Okayama University Graduate School of Medicine Okayama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shimeru","family":"Kamihira","sequence":"additional","affiliation":[{"name":"Laboratory Medicine Nagasaki Minato Medical Center Nagasaki Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazunari","family":"Yamaguchi","sequence":"additional","affiliation":[{"name":"Cell Modulation Institute of Molecular Embryology and Genetics Kumamoto University Kumamoto Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masanori","family":"Shimoyama","sequence":"additional","affiliation":[{"name":"Multicenter Institutional Clinical Trial Support Center National Cancer Center Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,1,18]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.1991.tb08051.x"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/0145-2126(91)90087-A"},{"key":"e_1_2_8_4_1","first-page":"281","volume-title":"WHO Classification of Tumour of Haemaopoietic and Lymphoid Tissues","author":"Ohshima K","year":"2008"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1309\/2YGD1P0QCVCWBLDX"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1346-8138.2008.00465.x"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2010-11-316794"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2011.38.2101"}],"container-title":["The Journal of 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