{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T06:52:28Z","timestamp":1789887148571,"version":"4.0.1"},"reference-count":26,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2014,1,29]],"date-time":"2014-01-29T00:00:00Z","timestamp":1390953600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Journal of Dermatology"],"published-print":{"date-parts":[[2014,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Although barrier function of psoriatic skin is shown to be decreased by measuring transepidermal water loss (<jats:styled-content style=\"fixed-case\">TEWL<\/jats:styled-content>), few reports exist examining other physical skin properties and components including stratum corneum hydration, natural moisturizing factor (<jats:styled-content style=\"fixed-case\">NMF<\/jats:styled-content>), free fatty acids (<jats:styled-content style=\"fixed-case\">FFA<\/jats:styled-content>), \u03b2\u2010sheet and \u03b1\u2010helix ratio of structural protein(s), and sebum content. We compared the skin properties and components of normal, involved and uninvolved skin of psoriasis. Using a corneometer and attenuated total reflection\u2010infrared spectrometer, we measured <jats:styled-content style=\"fixed-case\">TEWL<\/jats:styled-content>, stratum corneum hydration, <jats:styled-content style=\"fixed-case\">NMF<\/jats:styled-content>,<jats:styled-content style=\"fixed-case\"> FFA<\/jats:styled-content>, \u03b2\/\u03b1 ratio and sebum in psoriasis vulgaris patients and healthy controls. <jats:styled-content style=\"fixed-case\">TEWL<\/jats:styled-content> and \u03b2\/\u03b1 ratio of involved psoriatic skin were significantly increased compared with uninvolved skin and normal control skin. In contrast, stratum corneum hydration<jats:bold>, <jats:styled-content style=\"fixed-case\">NMF<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">FFA<\/jats:styled-content>, but not sebum, are significantly decreased in the involved skin compared with uninvolved skin and normal skin. <jats:styled-content style=\"fixed-case\">TEWL<\/jats:styled-content> and stratum corneum hydration returned to the normal levels following clinical improvement of the lesion. Barrier function and hydration of psoriatic skin are defective and secondary structure in stratum corneum protein is altered in the involved psoriatic skin.<\/jats:bold><\/jats:p>","DOI":"10.1111\/1346-8138.12393","type":"journal-article","created":{"date-parts":[[2014,1,29]],"date-time":"2014-01-29T10:29:53Z","timestamp":1390991393000},"page":"144-148","source":"Crossref","is-referenced-by-count":61,"title":["Defective barrier function accompanied by structural changes of psoriatic stratum corneum"],"prefix":"10.1111","volume":"41","author":[{"given":"Hidetoshi","family":"Takahashi","sequence":"first","affiliation":[{"name":"Department of Dermatology Asahikawa Medical University Asahikawa Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hitomi","family":"Tsuji","sequence":"additional","affiliation":[{"name":"Department of Dermatology Asahikawa Medical University Asahikawa Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masako","family":"Minami\u2010Hori","sequence":"additional","affiliation":[{"name":"Department of Dermatology Asahikawa Medical University Asahikawa Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuki","family":"Miyauchi","sequence":"additional","affiliation":[{"name":"Kao Corporation Higa\u2010Gun Tochigi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hajime","family":"Iizuka","sequence":"additional","affiliation":[{"name":"Department of Dermatology Asahikawa Medical University Asahikawa Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,1,29]]},"reference":[{"key":"e_1_2_6_2_1","first-page":"29","article-title":"Quantitative measurements of water concentration of the stratum corneum in vivo by high\u2010frequency current","volume":"195","author":"Tagami H.","year":"1994","journal-title":"Acta Derma Venereol suppl"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.1985.01660050094022"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.1973.tb15450.x"},{"key":"e_1_2_6_5_1","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1001\/archderm.1994.01690040056007","article-title":"Abnormality of water barrier function in psoriasis. 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