{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,29]],"date-time":"2026-01-29T20:43:47Z","timestamp":1769719427345,"version":"3.49.0"},"reference-count":19,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2014,2,10]],"date-time":"2014-02-10T00:00:00Z","timestamp":1391990400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Journal of Dermatology"],"published-print":{"date-parts":[[2014,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Common warts (verruca vulgaris) are the most commonly seen benign cutaneous tumors. However, warts in the hands and feet regions often respond poorly to treatment, some are resistant to more than 6\u00a0months of treatment with currently available modalities, including cryotherapy, being defined as refractory warts. We investigated the usefulness of long\u2010pulsed neodymium:yttrium\u2013aluminum\u2013garnet (<jats:styled-content style=\"fixed-case\">LP<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">N<\/jats:styled-content>d:<jats:styled-content style=\"fixed-case\">YAG<\/jats:styled-content>) treatment for refractory warts. The clinical trial was conducted on 20 subjects (11 male, nine female) with a total of 34 lesions (periungual\/subungual areas, plantar areas, fingers and\/or toes). All the subjects suffered from refractory warts despite conventional treatments for more than 6\u00a0months. The patients were administrated up to six sessions of treatment, at intervals of 4\u00a0weeks between sessions, with an<jats:styled-content style=\"fixed-case\">LP<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">N<\/jats:styled-content>d:<jats:styled-content style=\"fixed-case\">YAG<\/jats:styled-content>at a spot size of 5\u00a0mm, pulse duration of 15\u00a0msec and fluence of 150\u2013185\u00a0J\/cm<jats:sup>2<\/jats:sup>. Evaluation of the treatment results at 24\u00a0weeks after the initial treatment showed complete clearance of the refractory warts in 56% of the patients. Histological evaluation showed separation of the dermis and epidermis at the basement membrane with coagulated necrosis of the wart tissue in the lower epidermis, as well as coagulation and destruction of the blood vessels in the papillary dermis following the laser irradiation. No scarring, post\u2010hyperpigmentary changes or serious adverse events were documented. Our preliminary results show that<jats:styled-content style=\"fixed-case\">LP<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">N<\/jats:styled-content>d:<jats:styled-content style=\"fixed-case\">YAG<\/jats:styled-content>treatments are safe and effective for refractory warts of hands and feet, causing minimal discomfort, and is a viable treatment alternative.<\/jats:p>","DOI":"10.1111\/1346-8138.12411","type":"journal-article","created":{"date-parts":[[2014,2,10]],"date-time":"2014-02-10T07:36:44Z","timestamp":1392017804000},"page":"252-257","source":"Crossref","is-referenced-by-count":38,"title":["Long\u2010pulsed 1064\u2010nm neodymium:yttrium\u2013aluminum\u2013garnet laser treatment for refractory warts on hands and feet"],"prefix":"10.1111","volume":"41","author":[{"given":"Utako","family":"Kimura","sequence":"first","affiliation":[{"name":"Department of Dermatology Juntendo University Urayasu Hospital Chiba Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kaori","family":"Takeuchi","sequence":"additional","affiliation":[{"name":"Department of Dermatology Juntendo University Urayasu Hospital Chiba Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ayako","family":"Kinoshita","sequence":"additional","affiliation":[{"name":"Department of Dermatology Juntendo University Urayasu Hospital Chiba Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kenji","family":"Takamori","sequence":"additional","affiliation":[{"name":"Department of Dermatology Juntendo University Urayasu Hospital Chiba Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasushi","family":"Suga","sequence":"additional","affiliation":[{"name":"Department of Dermatology Juntendo University Urayasu Hospital Chiba 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