{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,7]],"date-time":"2026-03-07T04:16:09Z","timestamp":1772856969419,"version":"3.50.1"},"reference-count":8,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2014,3,17]],"date-time":"2014-03-17T00:00:00Z","timestamp":1395014400000},"content-version":"vor","delay-in-days":16,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Journal of Dermatology"],"published-print":{"date-parts":[[2014,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Adult <jats:styled-content style=\"fixed-case\">T<\/jats:styled-content>\u2010cell leukemia\u2013lymphoma (<jats:styled-content style=\"fixed-case\">ATL<\/jats:styled-content>) is one of the most malignant lymphomas with poor prognosis. <jats:styled-content style=\"fixed-case\">ATL<\/jats:styled-content> cells express <jats:styled-content style=\"fixed-case\">CC<\/jats:styled-content> chemokine receptor 4 (<jats:styled-content style=\"fixed-case\">CCR<\/jats:styled-content>4) and mogamulizumab, a monoclonal antibody against <jats:styled-content style=\"fixed-case\">CCR<\/jats:styled-content>4 that exhibits very strong cytotoxicity for <jats:styled-content style=\"fixed-case\">ATL<\/jats:styled-content> cells via antibody\u2010dependent cellular cytotoxicity. Although its effect is dramatic in <jats:styled-content style=\"fixed-case\">ATL<\/jats:styled-content>, serious adverse reactions such as <jats:styled-content style=\"fixed-case\">S<\/jats:styled-content>tevens\u2013<jats:styled-content style=\"fixed-case\">J<\/jats:styled-content>ohnson syndrome have been reported. However, these eruptions can appear as therapeutic signs of mogamulizumab. We evaluated the effectiveness of mogamulizumab in five acute\u2010type <jats:styled-content style=\"fixed-case\">ATL<\/jats:styled-content> patients. Peripheral blood (<jats:styled-content style=\"fixed-case\">PB<\/jats:styled-content>) and lymph nodes (<jats:styled-content style=\"fixed-case\">LN<\/jats:styled-content>) were affected in three and four patients, respectively. In <jats:styled-content style=\"fixed-case\">PB<\/jats:styled-content>, complete response (<jats:styled-content style=\"fixed-case\">CR<\/jats:styled-content>) was obtained in all three patients and partial response (<jats:styled-content style=\"fixed-case\">PR<\/jats:styled-content>) was recorded in <jats:styled-content style=\"fixed-case\">LN<\/jats:styled-content> of one patient. In skin lesions, four of five patients manifested <jats:styled-content style=\"fixed-case\">CR<\/jats:styled-content>; in two, the lesions worsened after the start of mogamulizumab treatment and subsequently improved. In these lesions, <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>4<jats:sup>+<\/jats:sup>8<jats:sup>\u2212<\/jats:sup>25<jats:sup>+<\/jats:sup> <jats:styled-content style=\"fixed-case\">ATL<\/jats:styled-content> cells were replaced by <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>3<jats:sup>+<\/jats:sup>8<jats:sup>+<\/jats:sup> cytotoxic <jats:styled-content style=\"fixed-case\">T<\/jats:styled-content> cells. Cutaneous adverse reactions (<jats:styled-content style=\"fixed-case\">CAR<\/jats:styled-content>) developed in two patients with <jats:styled-content style=\"fixed-case\">CR<\/jats:styled-content>; they did not show a relapse of <jats:styled-content style=\"fixed-case\">ATL<\/jats:styled-content> over the course of 9\u00a0months. Our findings suggest that mogamulizumab should be continued and surface marker evaluation should be performed even in patients whose skin lesions show aggravation, and that <jats:styled-content style=\"fixed-case\">CAR<\/jats:styled-content> may be a marker for a favorable prognosis.<\/jats:p>","DOI":"10.1111\/1346-8138.12419","type":"journal-article","created":{"date-parts":[[2014,3,17]],"date-time":"2014-03-17T04:59:52Z","timestamp":1395032392000},"page":"239-244","source":"Crossref","is-referenced-by-count":41,"title":["Effect of anti\u2010<scp>CCR<\/scp>4 monoclonal antibody (mogamulizumab) on adult <scp>T<\/scp>\u2010cell leukemia\u2013lymphoma: Cutaneous adverse reactions may predict the prognosis"],"prefix":"10.1111","volume":"41","author":[{"given":"Kentaro","family":"Yonekura","sequence":"first","affiliation":[{"name":"Department of Dermatology Imamura Bun\u2010in Hospital Kagoshima Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tamotsu","family":"Kanzaki","sequence":"additional","affiliation":[{"name":"Department of Dermatology Imamura Bun\u2010in Hospital Kagoshima Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kanayo","family":"Gunshin","sequence":"additional","affiliation":[{"name":"Department of Hematology Imamura Bun\u2010in Hospital Kagoshima Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nobuyo","family":"Kawakami","sequence":"additional","affiliation":[{"name":"Department of Dermatology Imamura Bun\u2010in Hospital Kagoshima Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshifusa","family":"Takatsuka","sequence":"additional","affiliation":[{"name":"Department of Dermatology Kagoshima University Graduate School of Medical and Dental Sciences Kagoshima 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