{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,27]],"date-time":"2026-05-27T14:41:36Z","timestamp":1779892896187,"version":"3.53.1"},"reference-count":42,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2014,2,18]],"date-time":"2014-02-18T00:00:00Z","timestamp":1392681600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Journal of Dermatology"],"published-print":{"date-parts":[[2014,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Valproic acid (\n                    <jats:styled-content style=\"fixed-case\">VPA<\/jats:styled-content>\n                    ), a widely used anticonvulsant, inhibits glycogen synthase kinase 3\u03b2 and activates the\n                    <jats:styled-content style=\"fixed-case\">W<\/jats:styled-content>\n                    nt\/\u03b2\u2010catenin pathway, which is associated with hair growth cycle and anagen induction. To assess the efficacy of topical\n                    <jats:styled-content style=\"fixed-case\">VPA<\/jats:styled-content>\n                    for treating androgenetic alopecia (\n                    <jats:styled-content style=\"fixed-case\">AGA<\/jats:styled-content>\n                    ), we performed a randomized, double\u2010blind, placebo\u2010controlled clinical trial. Male patients with moderate\n                    <jats:styled-content style=\"fixed-case\">AGA<\/jats:styled-content>\n                    underwent treatment with either\n                    <jats:styled-content style=\"fixed-case\">VPA<\/jats:styled-content>\n                    (sodium valproate, 8.3%) or placebo spray for 24\u00a0weeks. The primary end\u2010point for efficacy was the change in hair count during treatment, which was assessed by phototrichogram analysis. Of the 40 patients enrolled in the study, 27 (\n                    <jats:italic>n\u00a0<\/jats:italic>\n                    =\u00a015,\n                    <jats:styled-content style=\"fixed-case\">VPA<\/jats:styled-content>\n                    group;\n                    <jats:italic>n\u00a0<\/jats:italic>\n                    =\u00a012, placebo group) completed the entire protocol with good compliance. No statistical differences in age, hair loss duration and total hair count at baseline were found between the groups. The mean change in total hair count was significantly higher in the\n                    <jats:styled-content style=\"fixed-case\">VPA<\/jats:styled-content>\n                    group than in the placebo group (\n                    <jats:italic>P\u00a0<\/jats:italic>\n                    =\n                    <jats:italic>\u00a0<\/jats:italic>\n                    0.047). Both groups experienced mostly mild and self\u2010limited adverse events, but their differences in prevalence rates were similar between the two groups (\n                    <jats:italic>P\u00a0<\/jats:italic>\n                    =\n                    <jats:italic>\u00a0<\/jats:italic>\n                    0.72). A subject treated with topical\n                    <jats:styled-content style=\"fixed-case\">VPA<\/jats:styled-content>\n                    developed ventricular tachycardia, but it did not seem to be related to the\n                    <jats:styled-content style=\"fixed-case\">VPA<\/jats:styled-content>\n                    spray. Topical\n                    <jats:styled-content style=\"fixed-case\">VPA<\/jats:styled-content>\n                    increased the total hair counts of our patients; therefore, it is a potential treatment option for\n                    <jats:styled-content style=\"fixed-case\">AGA<\/jats:styled-content>\n                    .\n                  <\/jats:p>","DOI":"10.1111\/1346-8138.12422","type":"journal-article","created":{"date-parts":[[2014,2,18]],"date-time":"2014-02-18T06:39:56Z","timestamp":1392705596000},"page":"285-291","source":"Crossref","is-referenced-by-count":47,"title":["Topical valproic acid increases the hair count in male patients with androgenetic alopecia: A randomized, comparative, clinical feasibility study using phototrichogram analysis"],"prefix":"10.1111","volume":"41","author":[{"given":"Seong Jin","family":"Jo","sequence":"first","affiliation":[{"name":"Department of Dermatology Seoul National University College of Medicine Gyeonggi\u2010do 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Hwan","family":"Paik","sequence":"additional","affiliation":[{"name":"Department of Dermatology Seoul National University College of Medicine Gyeonggi\u2010do Korea"},{"name":"Institute of Human\u2010Environment Interface Biology Medical Research Center Seoul National University Gyeonggi\u2010do Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Won Seok","family":"Park","sequence":"additional","affiliation":[{"name":"Advanced Hair Research Laboratory R&amp;D Center AmorePacific Gyeonggi\u2010do Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yeon Su","family":"Jeong","sequence":"additional","affiliation":[{"name":"Advanced Hair Research Laboratory R&amp;D Center AmorePacific Gyeonggi\u2010do Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong Ju","family":"Shin","sequence":"additional","affiliation":[{"name":"Advanced Hair Research Laboratory R&amp;D Center AmorePacific Gyeonggi\u2010do 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