{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,20]],"date-time":"2025-09-20T20:09:11Z","timestamp":1758398951447},"reference-count":28,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2014,3,12]],"date-time":"2014-03-12T00:00:00Z","timestamp":1394582400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Journal of Dermatology"],"published-print":{"date-parts":[[2014,4]]},"abstract":"Abstract<\/jats:title>Human skin color is known to be associated with the risk of cutaneous cancer. Some reports indicated that pigmentation\u2010related gene variants were associated with cutaneous cancer risk in C<\/jats:styled-content>aucasian populations, but there are no similar reports in East A<\/jats:styled-content>sian populations. This study aimed to evaluate the association between pigmentation\u2010related genes and the risk of skin cancer in J<\/jats:styled-content>apanese populations. We studied the associations between 12 variants of four pigmentation\u2010related genes and melanin index variations in 198 J<\/jats:styled-content>apanese patients with skin cancer and compared these findings to those of 500 J<\/jats:styled-content>apanese controls by using multiple logistic regression analysis. Furthermore, we analyzed an independent sample of 107 J<\/jats:styled-content>apanese patients with skin cancer. A non\u2010synonymous variant, H615R in the oculocutaneous albinism 2 gene (OCA<\/jats:styled-content>2<\/jats:italic>), was associated with the risk of malignant melanoma in the Y<\/jats:styled-content>amagata group (odds ratio [OR<\/jats:styled-content>], 0.38; 95% confidence interval [CI<\/jats:styled-content>], 0.17\u20130.86; P<\/jats:italic>\u00a0=\u00a00.020). Another non\u2010synonymous variant, A481T in OCA<\/jats:styled-content>2<\/jats:italic>, was associated with the risk of squamous cell carcinoma and actinic keratosis in the O<\/jats:styled-content>saka group (OR<\/jats:styled-content>, 3.16; 95% CI<\/jats:styled-content>, 1.41\u20137.04; P<\/jats:italic>\u00a0=\u00a00.005). In malignant melanoma cases, the minor allele in OCA<\/jats:styled-content>2<\/jats:italic> H615R might have induced the development of lesions in sun\u2010exposed skin (OR<\/jats:styled-content>, 26.32; 95% CI<\/jats:styled-content>, 1.96\u2013333; P<\/jats:italic>\u00a0=\u00a00.014). Our results suggest that some OCA<\/jats:styled-content>2<\/jats:italic> variants are definite risk factors for the onset of cutaneous cancer in J<\/jats:styled-content>apanese populations.<\/jats:p>","DOI":"10.1111\/1346-8138.12432","type":"journal-article","created":{"date-parts":[[2014,3,12]],"date-time":"2014-03-12T10:18:44Z","timestamp":1394619524000},"page":"296-302","source":"Crossref","is-referenced-by-count":13,"title":["Variants in melanogenesis\u2010related genes associate with skin cancer risk among J<\/scp>apanese populations"],"prefix":"10.1111","volume":"41","author":[{"given":"Junko","family":"Yoshizawa","sequence":"first","affiliation":[{"name":"Department of Dermatology Yamagata University Faculty of Medicine Yamagata Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuko","family":"Abe","sequence":"additional","affiliation":[{"name":"Department of Dermatology Yamagata University Faculty of Medicine Yamagata Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naoki","family":"Oiso","sequence":"additional","affiliation":[{"name":"Department of Dermatology Kinki University Faculty of Medicine Osaka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazuyoshi","family":"Fukai","sequence":"additional","affiliation":[{"name":"Department of Dermatology Osaka City University Graduate School of Medicine Osaka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yutaka","family":"Hozumi","sequence":"additional","affiliation":[{"name":"Department of Dermatology Yamagata University Faculty of Medicine Yamagata Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomohiro","family":"Nakamura","sequence":"additional","affiliation":[{"name":"Advanced Molecular Epidemiology Research Institute Yamagata University Faculty of Medicine Yamagata Japan"},{"name":"Tohoku Medical Megabank Organization Tohoku University School of Medicine Sendai Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomohiko","family":"Narita","sequence":"additional","affiliation":[{"name":"Department of Dermatology Kinki University Faculty of Medicine Osaka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomonori","family":"Motokawa","sequence":"additional","affiliation":[{"name":"Skin Research Department POLA Chemical Industries Yokohama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazumasa","family":"Wakamatsu","sequence":"additional","affiliation":[{"name":"Department of Chemistry Fujita Health University School of Health Sciences Toyoake Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shosuke","family":"Ito","sequence":"additional","affiliation":[{"name":"Department of Chemistry Fujita Health University School of Health Sciences Toyoake Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akira","family":"Kawada","sequence":"additional","affiliation":[{"name":"Department of Dermatology Kinki University Faculty of Medicine Osaka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gen","family":"Tamiya","sequence":"additional","affiliation":[{"name":"Advanced Molecular Epidemiology Research Institute Yamagata University Faculty of Medicine Yamagata Japan"},{"name":"Tohoku Medical Megabank Organization Tohoku University School of Medicine Sendai Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tamio","family":"Suzuki","sequence":"additional","affiliation":[{"name":"Department of Dermatology Yamagata University Faculty of Medicine Yamagata 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