{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T19:14:31Z","timestamp":1789586071406,"version":"build-2803163510"},"reference-count":22,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2014,5,8]],"date-time":"2014-05-08T00:00:00Z","timestamp":1399507200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Journal of Dermatology"],"published-print":{"date-parts":[[2014,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Fractional radiofrequency microneedling is a novel radiofrequency technique that uses insulated microneedles to deliver energy to the deep dermis at the point of penetration without destruction of the epidermis. It has been used for the treatment of various dermatological conditions including wrinkles, atrophic scars and hypertrophic scars. There have been few studies evaluating the efficacy of fractional radiofrequency microneedling in the treatment of acne, and none measuring objective parameters like the number of inflammatory and non\u2010inflammatory acne lesions or sebum excretion levels. The safety and efficacy of fractional radiofrequency microneedling in the treatment of acne vulgaris was investigated. In a prospective clinical trial, 25 patients with moderate to severe acne were treated with fractional radiofrequency microneedling. The procedure was carried out three times at 1\u2010month intervals. Acne lesion count, subjective satisfaction score, sebum excretion level and adverse effects were assessed at baseline and at 4, 8 and 12\u00a0weeks after the first treatment as well as 4, 8 and 12\u00a0weeks after the last treatment. Number of acne lesions (inflammatory and non\u2010inflammatory) decreased. Sebum excretion and subjective satisfaction were more favorable at every time point compared with the baseline values (<jats:italic>P\u00a0<\/jats:italic>&lt;<jats:italic>\u00a0<\/jats:italic>0.05). Inflammatory lesions responded better than non\u2010inflammatory lesions (<jats:italic>P\u00a0&lt;\u00a0<\/jats:italic>0.05). Adverse effects such as pinpoint bleeding, pain and erythema were noted, but were transient and not severe enough to stop treatment. Fractional radiofrequency microneedling is a safe and effective treatment for acne vulgaris.<\/jats:p>","DOI":"10.1111\/1346-8138.12471","type":"journal-article","created":{"date-parts":[[2014,5,8]],"date-time":"2014-05-08T06:44:59Z","timestamp":1399531499000},"page":"586-591","source":"Crossref","is-referenced-by-count":66,"title":["Treatment of acne vulgaris with fractional radiofrequency microneedling"],"prefix":"10.1111","volume":"41","author":[{"given":"Sang Tae","family":"Kim","sequence":"first","affiliation":[{"name":"Department of Dermatology Kosin University College of Medicine Busan South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kang Hoon","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Dermatology Kosin University College of Medicine Busan South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyung Jun","family":"Sim","sequence":"additional","affiliation":[{"name":"Department of Dermatology Kosin University College of Medicine Busan South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kee Suck","family":"Suh","sequence":"additional","affiliation":[{"name":"Department of Dermatology Kosin University College of Medicine Busan South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min Soo","family":"Jang","sequence":"additional","affiliation":[{"name":"Department of Dermatology Kosin University College of Medicine Busan South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,5,8]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524-4725.2009.01258.x"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524-4725.2011.02267.x"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2004.01.023"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.sder.2008.07.005"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-3083.2009.03551.x"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(03)14629-6"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2010.09878.x"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1524-4725.2003.29081.x"},{"key":"e_1_2_7_10_1","first-page":"S23","article-title":"Use of themacool system thermage for treatment of facial acne","volume":"34","author":"Shah G","year":"2004","journal-title":"Lasers Surg Med"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1346-8138.2000.tb02262.x"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/lsm.20048"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/lsm.20254"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10103-009-0734-8"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524-4725.2010.01510.x"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/lsm.20453"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/lsm.20687"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.sder.2008.01.002"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1080\/14764170500231848"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/lsm.20731"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2230.2009.03291.x"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-3083.2007.02375.x"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/lsm.22200"}],"container-title":["The Journal of Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2F1346-8138.12471","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1346-8138.12471","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,23]],"date-time":"2023-09-23T18:11:03Z","timestamp":1695492663000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/1346-8138.12471"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,5,8]]},"references-count":22,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2014,7]]}},"alternative-id":["10.1111\/1346-8138.12471"],"URL":"https:\/\/doi.org\/10.1111\/1346-8138.12471","archive":["Portico"],"relation":{},"ISSN":["0385-2407","1346-8138"],"issn-type":[{"value":"0385-2407","type":"print"},{"value":"1346-8138","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,5,8]]}}}