{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,16]],"date-time":"2025-10-16T06:53:39Z","timestamp":1760597619724},"reference-count":19,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2014,4,19]],"date-time":"2014-04-19T00:00:00Z","timestamp":1397865600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Journal of Dermatology"],"published-print":{"date-parts":[[2014,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>In sporotrichosis, dermal dendritic cells were considered to participate in induction of the immune responses against <jats:italic><jats:styled-content style=\"fixed-case\">S<\/jats:styled-content>porothrix schenckii<\/jats:italic> infection. However, it is still unclear whether and how dermal dendritic cells were involved in the progress. To clarify the pathogenic role of dermal dendritic cells (<jats:styled-content style=\"fixed-case\">DC<\/jats:styled-content>) in sporotrichosis, we examined the phagocytosis, maturation stages, cytokine production and antigen\u2010presenting ability of mouse bone marrow\u2010derived <jats:styled-content style=\"fixed-case\">DC<\/jats:styled-content> after stimulation with <jats:italic>S.\u00a0schenckii<\/jats:italic>. By analysis of flow cytometry, electron microscope and confocal microscope, mouse bone marrow\u2010derived <jats:styled-content style=\"fixed-case\">DC<\/jats:styled-content> were proved to be able to phagocytize the <jats:italic>S.\u00a0schenckii<\/jats:italic>. The increased expression of <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>40, <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>80 and <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>86 on the surface of <jats:italic>S.\u00a0schenckii<\/jats:italic>\u2010pulsed mouse bone marrow\u2010derived <jats:styled-content style=\"fixed-case\">DC<\/jats:styled-content> was detected by flow cytometer, indicating that the <jats:italic>S.\u00a0schenckii<\/jats:italic>\u2010pulsed mouse bone marrow\u2010derived <jats:styled-content style=\"fixed-case\">DC<\/jats:styled-content> underwent the maturation program. The secretory enhancement of interleukin (<jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>)\u201012, but not <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u20104, was found in <jats:italic>S.\u00a0schenckii<\/jats:italic>\u2010pulsed mouse bone marrow\u2010derived <jats:styled-content style=\"fixed-case\">DC<\/jats:styled-content>, suggesting the possible activation of T\u2010helper 1 prone immune responses. Furthermore, <jats:italic>S.\u00a0schenckii<\/jats:italic>\u2010pulsed mouse bone marrow\u2010derived <jats:styled-content style=\"fixed-case\">DC<\/jats:styled-content> were demonstrated to be capable of inducing the proliferation of T lymphocytes from <jats:styled-content style=\"fixed-case\">BALB<\/jats:styled-content>\/c mice that were pre\u2010sensitized with <jats:italic>S.\u00a0schenckii<\/jats:italic>. Together, all the results implied that dermal <jats:styled-content style=\"fixed-case\">DC<\/jats:styled-content> may participate in the induction of immune responses against <jats:italic>S.\u00a0schenckii<\/jats:italic> infection in sporotrichosis.<\/jats:p>","DOI":"10.1111\/1346-8138.12472","type":"journal-article","created":{"date-parts":[[2014,4,19]],"date-time":"2014-04-19T11:20:03Z","timestamp":1397906403000},"page":"386-392","source":"Crossref","is-referenced-by-count":10,"title":["Mouse bone marrow\u2010derived dendritic cells can phagocytize the <i><scp>S<\/scp>porothrix schenckii<\/i>, and mature and activate the immune response by secreting interleukin\u201012 and presenting antigens to T lymphocytes"],"prefix":"10.1111","volume":"41","author":[{"given":"Masahiro","family":"Kusuhara","sequence":"first","affiliation":[{"name":"Department of Dermatology Kurume University School of Medicine, and Kurume University Institute of Cutaneous Cell Biology Fukuoka Japan"},{"name":"Kusuhara Dermatology Clinic Fukuoka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hua","family":"Qian","sequence":"additional","affiliation":[{"name":"Department of Dermatology Kurume University School of Medicine, and Kurume University Institute of Cutaneous Cell Biology Fukuoka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaoguang","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Dermatology Kurume University School of Medicine, and Kurume University Institute of Cutaneous Cell Biology Fukuoka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daisuke","family":"Tsuruta","sequence":"additional","affiliation":[{"name":"Department of Dermatology Kurume University School of Medicine, and Kurume University Institute of Cutaneous Cell Biology Fukuoka Japan"},{"name":"Department of Dermatology Osaka City University Graduate School of Medicine Osaka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Atsunari","family":"Tsuchisaka","sequence":"additional","affiliation":[{"name":"Department of Dermatology Kurume University School of Medicine, and Kurume University Institute of Cutaneous Cell Biology Fukuoka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Norito","family":"Ishii","sequence":"additional","affiliation":[{"name":"Department of Dermatology Kurume University School of Medicine, and Kurume University Institute of Cutaneous Cell Biology Fukuoka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chika","family":"Ohata","sequence":"additional","affiliation":[{"name":"Department of Dermatology Kurume University School of Medicine, and Kurume University Institute of Cutaneous Cell Biology Fukuoka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Minao","family":"Furumura","sequence":"additional","affiliation":[{"name":"Department of Dermatology Kurume University School of Medicine, and Kurume University Institute of Cutaneous Cell Biology Fukuoka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takashi","family":"Hashimoto","sequence":"additional","affiliation":[{"name":"Department of Dermatology Kurume University School of Medicine, and Kurume University Institute of Cutaneous Cell Biology Fukuoka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,4,19]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1086\/520190"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/clinids\/22.5.765"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1080\/mmy.40.2.111.114"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-280X.1999.00239.x"},{"key":"e_1_2_7_6_1","first-page":"527","article-title":"Immunohistochemical localization of activated and mature CD83+ dendritic cells in granulomas of sporotrichosis","volume":"11","author":"Koga T","year":"2001","journal-title":"Eur J Dermatol"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-065X.2007.00552.x"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri1745"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/intimm\/dxl097"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jiq037"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/0471142735.im0312s60"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1590\/S0037-86822002000600018"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0190-9622(99)70484-6"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.immunol.18.1.767"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1189\/jlb.0905517"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2010.05.001"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri1001"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature07036"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.2174\/1389201003378924"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.imbio.2012.04.006"}],"container-title":["The Journal of Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2F1346-8138.12472","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1346-8138.12472","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,24]],"date-time":"2023-09-24T10:06:17Z","timestamp":1695549977000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/1346-8138.12472"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,4,19]]},"references-count":19,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2014,5]]}},"alternative-id":["10.1111\/1346-8138.12472"],"URL":"https:\/\/doi.org\/10.1111\/1346-8138.12472","archive":["Portico"],"relation":{},"ISSN":["0385-2407","1346-8138"],"issn-type":[{"value":"0385-2407","type":"print"},{"value":"1346-8138","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,4,19]]}}}