{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,18]],"date-time":"2026-07-18T06:02:10Z","timestamp":1784354530040,"version":"3.55.0"},"reference-count":15,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2014,5,10]],"date-time":"2014-05-10T00:00:00Z","timestamp":1399680000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Journal of Dermatology"],"published-print":{"date-parts":[[2014,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Blepharochalasis is a rare disorder characterized by recurrent episodic swelling of eyelids, eventually leading to atrophy of skin. Although immunological mechanisms may be involved in the degradation of elastic fibers, the pathogenesis is not well characterized. We report a 10\u2010year\u2010old Japanese boy with an 11\u2010month history of the swelling of bilateral upper eyelids with atrophic skin. Attacks of non\u2010painful swelling in eyelids with erythema have recurred several times a month and lasted for 2\u20133\u00a0days. Histological examination revealed perivascular and interstitial infiltration of lymphocytes in the dermis. Elastica <jats:styled-content style=\"fixed-case\">V<\/jats:styled-content>an <jats:styled-content style=\"fixed-case\">G<\/jats:styled-content>ieson staining showed a marked decrease of elastic fibers throughout the dermis. Results of direct and indirect immunofluorescence analyses were negative. Staining of matrix metalloproteinase (<jats:styled-content style=\"fixed-case\">MMP<\/jats:styled-content>)\u20103 and <jats:styled-content style=\"fixed-case\">MMP<\/jats:styled-content>\u20109 was observed in and around infiltrating cells in the dermis, suggesting that <jats:styled-content style=\"fixed-case\">MMP<\/jats:styled-content>\u20103 and <jats:styled-content style=\"fixed-case\">MMP<\/jats:styled-content>\u20109 may play, in part, roles in the development of blepharochalasis, and that inhibitor of <jats:styled-content style=\"fixed-case\">MMP<\/jats:styled-content> may have a possibility of therapeutic application.<\/jats:p>","DOI":"10.1111\/1346-8138.12503","type":"journal-article","created":{"date-parts":[[2014,5,10]],"date-time":"2014-05-10T07:53:20Z","timestamp":1399708400000},"page":"536-538","source":"Crossref","is-referenced-by-count":17,"title":["Blepharochalasis: Possibly associated with matrix 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