{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T12:40:04Z","timestamp":1788439204583,"version":"build-2803163510"},"reference-count":19,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2014,6,9]],"date-time":"2014-06-09T00:00:00Z","timestamp":1402272000000},"content-version":"vor","delay-in-days":8,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Journal of Dermatology"],"published-print":{"date-parts":[[2014,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Some recent reports have revealed that the long scintigraphic appearance time (<jats:styled-content style=\"fixed-case\">SAT<\/jats:styled-content>), defined as the time between radionuclide injection and first sentinel lymph node (<jats:styled-content style=\"fixed-case\">SLN<\/jats:styled-content>) visualization in lymphoscintigraphy, is a negative predictive parameter of nodal metastasis in patients with melanoma. However, most of the methods used to measure the <jats:styled-content style=\"fixed-case\">SAT<\/jats:styled-content> were ambiguous because they utilized visualization in lymphoscintigraphy. We herein introduce a novel method by which to measure the <jats:styled-content style=\"fixed-case\">SAT<\/jats:styled-content> and lymphatic flow rate. The data of 33 patients with primary skin cancer were used. Sequential images were obtained using dynamic lymphoscintigraphy, and a time\u2013activity curve of the <jats:styled-content style=\"fixed-case\">SLN<\/jats:styled-content> was created. The time at which the counts reached plateau was newly defined as an alternative to the <jats:styled-content style=\"fixed-case\">SAT<\/jats:styled-content> and was termed the scintigraphic saturation time (<jats:styled-content style=\"fixed-case\">SST<\/jats:styled-content>). The figure obtained by division of the distance by the <jats:styled-content style=\"fixed-case\">SST<\/jats:styled-content> was newly defined as an alternative to the lymphatic flow rate and termed the lymphatic transit rate (<jats:styled-content style=\"fixed-case\">LTR<\/jats:styled-content>). The <jats:styled-content style=\"fixed-case\">SST<\/jats:styled-content> was clearly determined. It ranged from 220 to 1430\u00a0s (mean, 805\u00a0s). Pathological examination revealed nodal metastasis in five patients. In 28 patients without metastasis, the mean <jats:styled-content style=\"fixed-case\">LTR<\/jats:styled-content> was in the order of lower limbs (4.07\u00a0\u00b1\u00a00.35\u00a0cm\/min), upper limbs (2.67\u00a0\u00b1\u00a00.33\u00a0cm\/min), trunk (1.79\u00a0\u00b1\u00a00.47\u00a0cm\/min), and head and neck (1.11\u00a0\u00b1\u00a00.22\u00a0cm\/min). The <jats:styled-content style=\"fixed-case\">LTR<\/jats:styled-content>s were higher in patients with nodal metastasis than those without. This method may be effective for accurate measurement of the <jats:styled-content style=\"fixed-case\">SAT<\/jats:styled-content> and lymphatic flow rate.<\/jats:p>","DOI":"10.1111\/1346-8138.12506","type":"journal-article","created":{"date-parts":[[2014,6,9]],"date-time":"2014-06-09T11:08:27Z","timestamp":1402312107000},"page":"498-504","source":"Crossref","is-referenced-by-count":11,"title":["Measurement of cutaneous lymphatic flow rates in patients with skin cancer: area extraction method"],"prefix":"10.1111","volume":"41","author":[{"given":"Masao","family":"Fujiwara","sequence":"first","affiliation":[{"name":"Department of Plastic and Reconstructive Surgery Hamamatsu University School of Medicine Hamamatsu Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michifumi","family":"Sawada","sequence":"additional","affiliation":[{"name":"Department of Radiology Hamamatsu University School of Medicine Hamamatsu Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akira","family":"Kasuya","sequence":"additional","affiliation":[{"name":"Department of Dermatology Hamamatsu University School of Medicine Hamamatsu Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuki","family":"Matsushita","sequence":"additional","affiliation":[{"name":"Department of Plastic and Reconstructive Surgery Hamamatsu University School of Medicine Hamamatsu Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Moe","family":"Yamada","sequence":"additional","affiliation":[{"name":"Department of Plastic and Reconstructive Surgery Hamamatsu University School of Medicine Hamamatsu Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hidekazu","family":"Fukamizu","sequence":"additional","affiliation":[{"name":"Department of Plastic and Reconstructive Surgery Hamamatsu University School of Medicine Hamamatsu Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasuhiro","family":"Magata","sequence":"additional","affiliation":[{"name":"Department of Molecular Imaging Medical Photonics Research Center Hamamatsu University School of Medicine Hamamatsu Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshiki","family":"Tokura","sequence":"additional","affiliation":[{"name":"Department of Dermatology Hamamatsu University School of Medicine Hamamatsu Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harumi","family":"Sakahara","sequence":"additional","affiliation":[{"name":"Department of Radiology Hamamatsu University School of Medicine Hamamatsu Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,6,9]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02305661"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02306624"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/00008390-199806000-00012"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02303800"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.2353\/ajpath.2007.060761"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1593\/neo.08342"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00259-003-1114-4"},{"key":"e_1_2_7_9_1","first-page":"E225","article-title":"High negative predictive value of slow lymphatic drainage on metastatic node spread detection in malignant limb and trunk cutaneous melanoma","volume":"91","author":"Cammilleri S","year":"2004","journal-title":"Bull Cancer"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-008-0080-2"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejso.2010.05.003"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1089\/lrb.2012.0009"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/0-387-23604-X_2"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bjps.2007.12.074"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejvs.2008.04.013"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-009-0420-x"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00268-008-9519-7"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.11464"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjc.6601571"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.3800410"}],"container-title":["The Journal of Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2F1346-8138.12506","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1346-8138.12506","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,23]],"date-time":"2023-09-23T23:38:39Z","timestamp":1695512319000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/1346-8138.12506"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,6]]},"references-count":19,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2014,6]]}},"alternative-id":["10.1111\/1346-8138.12506"],"URL":"https:\/\/doi.org\/10.1111\/1346-8138.12506","archive":["Portico"],"relation":{},"ISSN":["0385-2407","1346-8138"],"issn-type":[{"value":"0385-2407","type":"print"},{"value":"1346-8138","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,6]]}}}