{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,4]],"date-time":"2026-02-04T16:15:28Z","timestamp":1770221728590,"version":"3.49.0"},"reference-count":10,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2014,7,2]],"date-time":"2014-07-02T00:00:00Z","timestamp":1404259200000},"content-version":"vor","delay-in-days":1,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Journal of Dermatology"],"published-print":{"date-parts":[[2014,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Paraneoplastic pemphigus (<jats:styled-content style=\"fixed-case\">PNP<\/jats:styled-content>) is an autoimmune bullous disease, which associates mainly with lymphoproliferative neoplasms. Bronchiolitis obliterans (<jats:styled-content style=\"fixed-case\">BO<\/jats:styled-content>) with progressive respiratory failure is a significant cause of death in <jats:styled-content style=\"fixed-case\">PNP<\/jats:styled-content>. We report a case of <jats:styled-content style=\"fixed-case\">PNP<\/jats:styled-content> associated with follicular lymphoma and <jats:styled-content style=\"fixed-case\">BO<\/jats:styled-content>, which showed findings suggesting coexistence of bullous pemphigoid (<jats:styled-content style=\"fixed-case\">BP<\/jats:styled-content>). The patient showed bullous and ulcerative lesions on the lips and oral cavity, and flaccid blisters on the trunk and thighs associated with anti\u2010desmoglein (<jats:styled-content style=\"fixed-case\">D<\/jats:styled-content>sg)3 antibodies. At later disease stage after commencement of treatment, anti\u2010<jats:styled-content style=\"fixed-case\">BP<\/jats:styled-content>180 antibodies and tense blister formation were observed. It was proposed that persistent interface dermatitis is the first event in <jats:styled-content style=\"fixed-case\">PNP<\/jats:styled-content>, and subsequently induce the production of autoantibodies to <jats:styled-content style=\"fixed-case\">D<\/jats:styled-content>sg and components of the basement membrane zone, resulting in both intraepidermal and subepidermal blisters. We speculate that interface dermatitis caused by autoreactive T cells induced autoantibody production against <jats:styled-content style=\"fixed-case\">D<\/jats:styled-content>sg3, and subsequently against <jats:styled-content style=\"fixed-case\">BP<\/jats:styled-content>180.<\/jats:p>","DOI":"10.1111\/1346-8138.12521","type":"journal-article","created":{"date-parts":[[2014,7,2]],"date-time":"2014-07-02T10:18:17Z","timestamp":1404296297000},"page":"628-630","source":"Crossref","is-referenced-by-count":6,"title":["Paraneoplastic pemphigus associated with fatal bronchiolitis obliterans and appearance of anti\u2010<scp>BP<\/scp>180 antibodies in the late stage of the disease"],"prefix":"10.1111","volume":"41","author":[{"given":"Miwa","family":"Kanaoka","sequence":"first","affiliation":[{"name":"Department of Dermatology Yokohama City University School of Medicine Yokohama Kanagawa Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Setsuko","family":"Matsukura","sequence":"additional","affiliation":[{"name":"Department of Dermatology Yokohama City University School of Medicine Yokohama Kanagawa Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hideyuki","family":"Ishikawa","sequence":"additional","affiliation":[{"name":"Department of Dermatology Yokohama City University School of Medicine Yokohama Kanagawa Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Midori","family":"Matsuura","sequence":"additional","affiliation":[{"name":"Department of Dermatology Yokohama City University School of Medicine Yokohama Kanagawa Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Norito","family":"Ishii","sequence":"additional","affiliation":[{"name":"Department of Dermatology Kurume University School of Medicine and Kurume University Institute of Cutaneous Cell Biology Kurume Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takashi","family":"Hashimoto","sequence":"additional","affiliation":[{"name":"Department of Dermatology Kurume University School of Medicine and Kurume University Institute of Cutaneous Cell Biology Kurume Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michiko","family":"Aihara","sequence":"additional","affiliation":[{"name":"Department of Dermatology Yokohama City University School of Medicine Yokohama Kanagawa Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,7,2]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199012203232503"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199905063401805"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1067\/mjd.2000.107488"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI57379"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-3083.2008.03071.x"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.12479"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200307243490421"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1203536"},{"key":"e_1_2_5_10_1","first-page":"617","article-title":"Paraneoplastic autoimmune multiorgan syndrome: review of the literature and support for a cytotoxic role in pathogenesis","volume":"36","author":"Sara EB","year":"2006","journal-title":"Autoimmunity"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2003.05659.x"}],"container-title":["The Journal of Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2F1346-8138.12521","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1346-8138.12521","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,23]],"date-time":"2023-09-23T18:11:52Z","timestamp":1695492712000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/1346-8138.12521"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,7]]},"references-count":10,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2014,7]]}},"alternative-id":["10.1111\/1346-8138.12521"],"URL":"https:\/\/doi.org\/10.1111\/1346-8138.12521","archive":["Portico"],"relation":{},"ISSN":["0385-2407","1346-8138"],"issn-type":[{"value":"0385-2407","type":"print"},{"value":"1346-8138","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,7]]}}}