{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,21]],"date-time":"2026-02-21T12:56:45Z","timestamp":1771678605327,"version":"3.50.1"},"reference-count":56,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2014,8,7]],"date-time":"2014-08-07T00:00:00Z","timestamp":1407369600000},"content-version":"vor","delay-in-days":6,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Journal of Dermatology"],"published-print":{"date-parts":[[2014,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Psoriasis is thought to be a multifactorial disease triggered by both genetic and environmental factors. The <jats:italic><jats:styled-content style=\"fixed-case\">HLA<\/jats:styled-content>\u2010C<\/jats:italic> locus on chromosome 6p21.33 remains the strongest susceptibility candidate locus in psoriasis. The strong association between psoriasis and the <jats:italic><jats:styled-content style=\"fixed-case\">HLA<\/jats:styled-content>\u2010Cw6<\/jats:italic> allele has been well documented in various races. It is known that psoriatic patients with early onset are more likely to be familial and associated with <jats:italic><jats:styled-content style=\"fixed-case\">HLA<\/jats:styled-content>\u2010Cw6<\/jats:italic>. Familial occurrence of Japanese psoriasis is smaller than other populations. Furthermore, males are predominant over females in Japanese psoriasis. We investigated the relation between <jats:italic><jats:styled-content style=\"fixed-case\">HLA<\/jats:styled-content>\u2010C<\/jats:italic> alleles and age of onset, and in each gender for Japanese psoriasis, and discuss male predominance in the incidence of psoriasis in Japan. Four hundred forty six unrelated Japanese patients with psoriasis vulgaris and 557 sex\u2010 and age\u2010matched unrelated Japanese healthy controls were investigated by genotyping. We confirmed the association between early\u2010onset type of psoriasis with <jats:italic><jats:styled-content style=\"fixed-case\">HLA<\/jats:styled-content>\u2010C*06:02<\/jats:italic> allele in Japanese. In addition, we detected the association between the late\u2010onset type of psoriasis and the <jats:italic><jats:styled-content style=\"fixed-case\">HLA<\/jats:styled-content>\u2010C*12:02<\/jats:italic> allele in Japanese. No significant differences in allele frequency were observed between females and males. Our results suggest that there is no genetic factor effect on male predominance in Japanese. In contract, the effect of environmental risk factors on the onset of Japanese psoriatic patients is stronger in males than in females. As a result, male predominant in psoriasis may occur in Japan.<\/jats:p>","DOI":"10.1111\/1346-8138.12569","type":"journal-article","created":{"date-parts":[[2014,8,7]],"date-time":"2014-08-07T09:46:51Z","timestamp":1407404811000},"page":"697-704","source":"Crossref","is-referenced-by-count":33,"title":["<i><scp>HLA<\/scp>\u2010C*12:02<\/i> is a susceptibility factor in late\u2010onset type of psoriasis in Japanese"],"prefix":"10.1111","volume":"41","author":[{"given":"Tomotaka","family":"Mabuchi","sequence":"first","affiliation":[{"name":"Department of Dermatology Tokai University School of Medicine Isehara Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tami","family":"Ota","sequence":"additional","affiliation":[{"name":"Department of Dermatology Tokai University School of Medicine Isehara Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasuaki","family":"Manabe","sequence":"additional","affiliation":[{"name":"Department of Dermatology 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