{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T16:32:49Z","timestamp":1778862769440,"version":"3.51.4"},"reference-count":3,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2014,8,7]],"date-time":"2014-08-07T00:00:00Z","timestamp":1407369600000},"content-version":"vor","delay-in-days":6,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Journal of Dermatology"],"published-print":{"date-parts":[[2014,8]]},"abstract":"Abstract<\/jats:title>Photodynamic therapy (PDT<\/jats:styled-content>) is useful for superficial skin tumors such as actinic keratosis and Bowen disease. Although PDT<\/jats:styled-content> is non\u2010surgical and easily\u2010performed treatment modality, irradiation apparatus is large and expensive. Using 7, 12\u2010dimethylbenz[a]anthracene (DMBA<\/jats:styled-content>) and 12\u2010\u03bf\u2010tetradecanoylphorbol\u201013\u2010acetate (TPA<\/jats:styled-content>)\u2010induced mouse skin papilloma model, we compared the efficacy of TONS<\/jats:styled-content>501\u2010 and ALA<\/jats:styled-content>\u2010PDT<\/jats:styled-content> with a LED<\/jats:styled-content> lamp, a diode laser lamp or a metal\u2010halide lamp on the skin tumor regression. TONS<\/jats:styled-content>501\u2010PDT<\/jats:styled-content> using 660\u00a0nm LED<\/jats:styled-content> lamp showed anti\u2010tumor effect at 1\u00a0day following the irradiation and the maximal anti\u2010tumor effect was observed at 3\u00a0days following the irradiation. There was no significant difference in the anti\u2010tumor effects among TONS<\/jats:styled-content>501\u2010PDT<\/jats:styled-content> using LED<\/jats:styled-content>, TONS<\/jats:styled-content>501\u2010PDT<\/jats:styled-content> using diode laser, and 5\u2010aminolevulinic acid hydrochloride (ALA<\/jats:styled-content>)\u2010PDT<\/jats:styled-content> using metal\u2010halide lamp. Potent anti\u2010tumor effect on DMBA<\/jats:styled-content>\u2010 and TPA<\/jats:styled-content>\u2010induced mouse skin papilloma was observed by TONS<\/jats:styled-content>501\u2010PDT<\/jats:styled-content> using 660\u00a0nm LED<\/jats:styled-content>, which might be more useful for clinical applications.<\/jats:p>","DOI":"10.1111\/1346-8138.12572","type":"journal-article","created":{"date-parts":[[2014,8,7]],"date-time":"2014-08-07T09:46:51Z","timestamp":1407404811000},"page":"729-731","source":"Crossref","is-referenced-by-count":12,"title":["Photodynamic therapy using a novel irradiation source, LED<\/scp> lamp, is similarly effective to photodynamic therapy using diode laser or metal\u2010halide lamp on DMBA<\/scp>\u2010 and TPA<\/scp>\u2010induced mouse skin papillomas"],"prefix":"10.1111","volume":"41","author":[{"given":"Hidetoshi","family":"Takahashi","sequence":"first","affiliation":[{"name":"Department of Dermatology Asahikawa Medical University Asahikawa Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susumu","family":"Nakajima","sequence":"additional","affiliation":[{"name":"Moriyama Memorial Hospital Asahikawa Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Koji","family":"Ogasawara","sequence":"additional","affiliation":[{"name":"Sarufutsu Hokuho Hospital Hamatonbetsu Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ryuji","family":"Asano","sequence":"additional","affiliation":[{"name":"Photochemcal Co.Ltd. Okayama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshinori","family":"Nakae","sequence":"additional","affiliation":[{"name":"Photochemcal Co.Ltd. Okayama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Isao","family":"Sakata","sequence":"additional","affiliation":[{"name":"Photochemcal Co.Ltd. Okayama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hajime","family":"Iizuka","sequence":"additional","affiliation":[{"name":"Department of Dermatology Asahikawa Medical University Asahikawa Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,8,7]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.2165\/00128071-200001020-00009"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdermsci.2009.03.008"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdermsci.2012.02.005"}],"container-title":["The Journal of Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2F1346-8138.12572","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1346-8138.12572","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,24]],"date-time":"2023-09-24T08:27:17Z","timestamp":1695544037000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/1346-8138.12572"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,8]]},"references-count":3,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2014,8]]}},"alternative-id":["10.1111\/1346-8138.12572"],"URL":"https:\/\/doi.org\/10.1111\/1346-8138.12572","archive":["Portico"],"relation":{},"ISSN":["0385-2407","1346-8138"],"issn-type":[{"value":"0385-2407","type":"print"},{"value":"1346-8138","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,8]]}}}