{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,19]],"date-time":"2025-09-19T08:08:56Z","timestamp":1758269336127},"reference-count":10,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2014,8,11]],"date-time":"2014-08-11T00:00:00Z","timestamp":1407715200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Journal of Dermatology"],"published-print":{"date-parts":[[2014,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>A 70\u2010year\u2010old man presented with papular skin lesions and was diagnosed with <jats:styled-content style=\"fixed-case\">E<\/jats:styled-content>pstein\u2013<jats:styled-content style=\"fixed-case\">B<\/jats:styled-content>arr virus (<jats:styled-content style=\"fixed-case\">EBV<\/jats:styled-content>)\u2010associated <jats:styled-content style=\"fixed-case\">T<\/jats:styled-content>\u2010cell lymphoproliferative disorder (T\u2010<jats:styled-content style=\"fixed-case\">LPD<\/jats:styled-content>). The patient showed infiltration of a large number of <jats:styled-content style=\"fixed-case\">EBV<\/jats:styled-content>\u2010encoded <jats:styled-content style=\"fixed-case\">RNA<\/jats:styled-content>\u2010positive T cells in the skin and lung, presence of <jats:styled-content style=\"fixed-case\">EBV<\/jats:styled-content> load in the peripheral blood, and expansion of clonal <jats:styled-content style=\"fixed-case\">EBV<\/jats:styled-content>\u2010infected \u03b3\u03b4 <jats:styled-content style=\"fixed-case\">T<\/jats:styled-content> cells and <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>8<jats:sup>+<\/jats:sup> <jats:styled-content style=\"fixed-case\">T<\/jats:styled-content> cells in the blood and skin, as assessed by <jats:styled-content style=\"fixed-case\">EBV<\/jats:styled-content>\u2010terminal repeat <jats:styled-content style=\"fixed-case\">S<\/jats:styled-content>outhern blot, <jats:styled-content style=\"fixed-case\">T<\/jats:styled-content>\u2010cell receptor polymerase chain reaction and flow cytometric analyses. In the <jats:styled-content style=\"fixed-case\">J<\/jats:styled-content>apanese or <jats:styled-content style=\"fixed-case\">E<\/jats:styled-content>ast <jats:styled-content style=\"fixed-case\">A<\/jats:styled-content>sian fatal cases of <jats:styled-content style=\"fixed-case\">EBV<\/jats:styled-content>\u2010associated <jats:styled-content style=\"fixed-case\">T<\/jats:styled-content>\/natural killer (<jats:styled-content style=\"fixed-case\">NK<\/jats:styled-content>)\u2010<jats:styled-content style=\"fixed-case\">LPD<\/jats:styled-content>, there are two peaks in age at death, approximately 20\u00a0years and 60\u00a0years. The former age group is associated with chronic active <jats:styled-content style=\"fixed-case\">EBV<\/jats:styled-content> infection (<jats:styled-content style=\"fixed-case\">CAEBV<\/jats:styled-content>), and the latter group typically suffers from extranodal <jats:styled-content style=\"fixed-case\">NK<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">T<\/jats:styled-content>\u2010cell lymphoma. Our case is characterized not only by the unique skin and lung manifestations but also the late onset age of the disease, indicating that the skin manifestation of <jats:styled-content style=\"fixed-case\">CAEBV<\/jats:styled-content> can be seen even in elderly patients.<\/jats:p>","DOI":"10.1111\/1346-8138.12585","type":"journal-article","created":{"date-parts":[[2014,8,11]],"date-time":"2014-08-11T09:56:31Z","timestamp":1407750991000},"page":"837-840","source":"Crossref","is-referenced-by-count":5,"title":["Epstein\u2013Barr virus\u2010associated T\u2010cell lymphoproliferative disorder affecting skin and lung in an elderly patient"],"prefix":"10.1111","volume":"41","author":[{"given":"Tomomi","family":"Hoshino","sequence":"first","affiliation":[{"name":"Department of Dermatology Hamamatsu University School of Medicine Hamamatsu Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazuki","family":"Tatsuno","sequence":"additional","affiliation":[{"name":"Department of Dermatology Hamamatsu University School of Medicine Hamamatsu Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takatoshi","family":"Shimauchi","sequence":"additional","affiliation":[{"name":"Department of Dermatology Hamamatsu University School of Medicine Hamamatsu Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Satoko","family":"Okada","sequence":"additional","affiliation":[{"name":"Department of Dermatology Hamamatsu University School of Medicine Hamamatsu Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Taisuke","family":"Ito","sequence":"additional","affiliation":[{"name":"Department of Dermatology Hamamatsu University School of Medicine Hamamatsu Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takaaki","family":"Ono","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine III Hamamatsu University School of Medicine Hamamatsu Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Koichi","family":"Ohshima","sequence":"additional","affiliation":[{"name":"Department of Pathology School of Medicine Kurume University Kurume Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshiki","family":"Tokura","sequence":"additional","affiliation":[{"name":"Department of Dermatology Hamamatsu University School of Medicine Hamamatsu Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,8,11]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2011-10-381921"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1827.2008.02213.x"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12185-012-1156-0"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2011.461"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.20398"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1067\/mjd.2001.114751"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2011-05-354142"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.3109\/s10165-012-0731-9"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.3109\/s10165-012-0620-2"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12185-011-0831-x"}],"container-title":["The Journal of Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2F1346-8138.12585","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2F1346-8138.12585","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1346-8138.12585","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,23]],"date-time":"2023-09-23T21:47:21Z","timestamp":1695505641000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/1346-8138.12585"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,8,11]]},"references-count":10,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2014,9]]}},"alternative-id":["10.1111\/1346-8138.12585"],"URL":"https:\/\/doi.org\/10.1111\/1346-8138.12585","archive":["Portico"],"relation":{},"ISSN":["0385-2407","1346-8138"],"issn-type":[{"value":"0385-2407","type":"print"},{"value":"1346-8138","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,8,11]]}}}