{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T19:35:30Z","timestamp":1782502530505,"version":"3.54.5"},"reference-count":30,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2014,9,16]],"date-time":"2014-09-16T00:00:00Z","timestamp":1410825600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Journal of Dermatology"],"published-print":{"date-parts":[[2014,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Hypertrophic scarring leads to a deformed appearance and contracted neogenetic tissue, resulting in physiological and psychological problems for patients. Millions of people suffer these discomforts each year. Emerging evidence has reported that mi<jats:styled-content style=\"fixed-case\">RNA<\/jats:styled-content>contributed to hypertrophic scarring or keloid formation. In this study, nine hypertrophic scar samples and the matched normal skin tissues were used to perform a mi<jats:styled-content style=\"fixed-case\">RNA<\/jats:styled-content>microarray. The results of mi<jats:styled-content style=\"fixed-case\">RNA<\/jats:styled-content>array showed that miR\u2010200b was downregulated by more than 2\u2010fold, validated by q<jats:styled-content style=\"fixed-case\">PCR<\/jats:styled-content>in hypertrophic scar tissues and human hypertrophic scar fibroblasts, suggesting that there was an important correlation between miR\u2010200b and hypertrophic scarring. We also found that miR\u2010200b affected hypertrophic scarring through regulating the cell proliferation and apoptosis of human hypertrophic scar fibroblasts by affecting the collagen I and III synthesis, fibronectin expression and<jats:styled-content style=\"fixed-case\">TGF<\/jats:styled-content>\u2010\u03b21\/\u03b1\u2010<jats:styled-content style=\"fixed-case\">SMA<\/jats:styled-content>signaling. Thus, our study provides evidence to support that miR\u2010200b may be a useful target for hypertrophic scarring management.<\/jats:p>","DOI":"10.1111\/1346-8138.12600","type":"journal-article","created":{"date-parts":[[2014,9,16]],"date-time":"2014-09-16T12:35:09Z","timestamp":1410870909000},"page":"903-911","source":"Crossref","is-referenced-by-count":54,"title":["Overexpression of miR\u2010200b inhibits the cell proliferation and promotes apoptosis of human hypertrophic scar fibroblasts<i>in vitro<\/i>"],"prefix":"10.1111","volume":"41","author":[{"given":"Ping","family":"Li","sequence":"first","affiliation":[{"name":"Department of Plastic Surgery The Third Xiang\u2010Ya Hospital Central South University Changsha China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Quan\u2010Yong","family":"He","sequence":"additional","affiliation":[{"name":"Department of Plastic Surgery The Third Xiang\u2010Ya Hospital Central South University Changsha China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheng\u2010Qun","family":"Luo","sequence":"additional","affiliation":[{"name":"Department of Plastic Surgery The Third Xiang\u2010Ya Hospital Central South University Changsha China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,9,16]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.2119\/molmed.2009.00153"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1540-9740.2005.02507.x"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/path.2081"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.mt.6300311"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2013.12.043"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng1744"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1634\/theoncologist.2012-0081"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1620\/tjem.221.203"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.burns.2011.10.014"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00266-011-9773-1"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10616-007-9049-4"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-08-2920"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.3892\/or.2013.2897"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M113.453043"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.13-13422"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524-475X.2007.00226.x"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1097\/00006534-200108000-00022"},{"issue":"1","key":"e_1_2_7_19_1","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.jaad.2011.05.055","article-title":"Cutaneous scarring: pathophysiology, molecular mechanisms, and scar reduction therapeutics Part I. 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