{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T02:59:28Z","timestamp":1772765968166,"version":"3.50.1"},"reference-count":24,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2014,10,8]],"date-time":"2014-10-08T00:00:00Z","timestamp":1412726400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Journal of Dermatology"],"published-print":{"date-parts":[[2014,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Psoriasis is a chronic inflammatory skin disease, which may be associated with metabolic syndrome accompanied by cardio\u2010 and cerebrovascular diseases. We investigated the relation between serum <jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>\u2010reactive protein (<jats:styled-content style=\"fixed-case\">CRP<\/jats:styled-content>) and cardio\u2010 and cerebrovascular diseases in Japanese psoriasis vulgaris patients. Ninety\u2010seven psoriasis vulgaris patients and 79 healthy controls were assessed for serum <jats:styled-content style=\"fixed-case\">CRP<\/jats:styled-content> levels by immunoturbidimetry. The data were analyzed in terms of <jats:styled-content style=\"fixed-case\">P<\/jats:styled-content>soriasis <jats:styled-content style=\"fixed-case\">A<\/jats:styled-content>rea and <jats:styled-content style=\"fixed-case\">S<\/jats:styled-content>everity <jats:styled-content style=\"fixed-case\">I<\/jats:styled-content>ndex (<jats:styled-content style=\"fixed-case\">PASI<\/jats:styled-content>) scores, and comorbidity of cardio\u2010 and cerebrovascular disease and metabolic syndrome. Serum <jats:styled-content style=\"fixed-case\">CRP<\/jats:styled-content> levels in psoriasis vulgaris patients were significantly higher than those of healthy controls. There was no significant difference between male and female <jats:styled-content style=\"fixed-case\">CRP<\/jats:styled-content> levels in either psoriasis or healthy controls. No correlation was detected between <jats:styled-content style=\"fixed-case\">PASI<\/jats:styled-content> scores and serum <jats:styled-content style=\"fixed-case\">CRP<\/jats:styled-content> levels, either. Psoriasis with cardio\u2010 and cerebrovascular disease showed significantly higher <jats:styled-content style=\"fixed-case\">CRP<\/jats:styled-content> levels compared with those without the diseases. Furthermore, psoriasis with metabolic syndrome showed significantly higher serum <jats:styled-content style=\"fixed-case\">CRP<\/jats:styled-content> levels than those without the metabolic syndrome. In conclusion, serum <jats:styled-content style=\"fixed-case\">CRP<\/jats:styled-content> level is increased in psoriasis, and may be a useful marker for the prediction of the future risk of cardio\u2010 and cerebrovascular disease.<\/jats:p>","DOI":"10.1111\/1346-8138.12632","type":"journal-article","created":{"date-parts":[[2014,10,8]],"date-time":"2014-10-08T06:49:44Z","timestamp":1412750984000},"page":"981-985","source":"Crossref","is-referenced-by-count":21,"title":["Increased serum C\u2010reactive protein level in Japanese patients of psoriasis with cardio\u2010 and cerebrovascular disease"],"prefix":"10.1111","volume":"41","author":[{"given":"Hidetoshi","family":"Takahashi","sequence":"first","affiliation":[{"name":"Department of Dermatology Asahikawa Medical University Asahikawa Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shin","family":"Iinuma","sequence":"additional","affiliation":[{"name":"Department of Dermatology Asahikawa Medical University 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