{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,23]],"date-time":"2026-02-23T15:03:52Z","timestamp":1771859032634,"version":"3.50.1"},"reference-count":27,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2014,10,8]],"date-time":"2014-10-08T00:00:00Z","timestamp":1412726400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Journal of Dermatology"],"published-print":{"date-parts":[[2014,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Homocysteine is a sulfhydryl\u2010containing amino acid that is derived from dietary methionine, and there has been increasing evidence that elevated plasma homocysteine levels are associated with increased risk of cardiovascular diseases, including carotid, coronary and peripheral arterial disease (<jats:styled-content style=\"fixed-case\">PAD<\/jats:styled-content>). The association of plasma homocysteine levels with peripheral vascular involvements, such as Raynaud phenomenon (<jats:styled-content style=\"fixed-case\">RP<\/jats:styled-content>), digital ulcers (<jats:styled-content style=\"fixed-case\">DU<\/jats:styled-content>) in systemic sclerosis (<jats:styled-content style=\"fixed-case\">SS<\/jats:styled-content>c) patients has not been well studied. The objective of this study was to examine plasma homocysteine levels and their clinical associations in patients with <jats:styled-content style=\"fixed-case\">SS<\/jats:styled-content>c. Plasma homocysteine levels in 151 Japanese patients with <jats:styled-content style=\"fixed-case\">SS<\/jats:styled-content>c and 20 healthy controls were examined. No significant differences were observed in plasma homocysteine levels between <jats:styled-content style=\"fixed-case\">SS<\/jats:styled-content>c patients and healthy individuals. Demographic and clinical features of the <jats:styled-content style=\"fixed-case\">SS<\/jats:styled-content>c patients revealed that severe skin sclerosis, anti\u2010topoisomerase I antibody positivity, complications of <jats:styled-content style=\"fixed-case\">DU<\/jats:styled-content>, acro\u2010osteolysis (<jats:styled-content style=\"fixed-case\">AO<\/jats:styled-content>) and interstitial lung disease (<jats:styled-content style=\"fixed-case\">ILD<\/jats:styled-content>) were significantly more prevalent among the patients with elevated plasma homocysteine levels. The plasma homocysteine levels were positively correlated with modified Rodnan total skin score. The plasma homocysteine levels in the <jats:styled-content style=\"fixed-case\">SS<\/jats:styled-content>c patients with <jats:styled-content style=\"fixed-case\">DU<\/jats:styled-content>,<jats:styled-content style=\"fixed-case\"> AO<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">ILD<\/jats:styled-content> were significantly higher than those in the <jats:styled-content style=\"fixed-case\">SS<\/jats:styled-content>c without <jats:styled-content style=\"fixed-case\">DU<\/jats:styled-content>,<jats:styled-content style=\"fixed-case\"> AO<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">ILD<\/jats:styled-content>, respectively. Plasma homocysteine levels did not correlate with either the mean or max intima\u2010media thickness (<jats:styled-content style=\"fixed-case\">IMT<\/jats:styled-content>) or plaque score, suggesting that plasma homocysteine levels might not be associated with carotid artery atherosclerosis in <jats:styled-content style=\"fixed-case\">SS<\/jats:styled-content>c patients. The measurement of plasma homocysteine levels in <jats:styled-content style=\"fixed-case\">SS<\/jats:styled-content>c patients might be useful for the risk stratifications of severe skin sclerosis, <jats:styled-content style=\"fixed-case\">DU<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">AO<\/jats:styled-content>.<\/jats:p>","DOI":"10.1111\/1346-8138.12642","type":"journal-article","created":{"date-parts":[[2014,10,8]],"date-time":"2014-10-08T06:51:03Z","timestamp":1412751063000},"page":"986-991","source":"Crossref","is-referenced-by-count":20,"title":["Elevated plasma homocysteine level is possibly associated with skin sclerosis in a series of Japanese patients with systemic sclerosis"],"prefix":"10.1111","volume":"41","author":[{"given":"Sei\u2010ichiro","family":"Motegi","sequence":"first","affiliation":[{"name":"Department of Dermatology Gunma University Graduate School of Medicine Maebashi Gunma 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