{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,23]],"date-time":"2025-10-23T05:27:38Z","timestamp":1761197258910},"reference-count":4,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2014,10,30]],"date-time":"2014-10-30T00:00:00Z","timestamp":1414627200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Journal of Dermatology"],"published-print":{"date-parts":[[2015,1]]},"abstract":"Abstract<\/jats:title>Lichen planus (LP<\/jats:styled-content>) is a chronic inflammatory disorder involving the skin or mucous membranes. Previous studies have demonstrated that some LP<\/jats:styled-content> patients showed positive enzyme\u2010linked immunosorbent assay (ELISA<\/jats:styled-content>) for desmoglein (DSG<\/jats:styled-content>) antibodies. We report a case with intractable painful oral lesions. ELISA<\/jats:styled-content> indices for DSG<\/jats:styled-content>1 and 3 antibodies were increased by 49 and 36, respectively. Histopathological analysis revealed irregular acanthosis and band\u2010like infiltration of lymphocytes at the dermal\u2013epidermal interface. Direct immunofluorescence revealed negative deposits of immunoglobulin G and C3 in intracellular spaces of the epidermis. Indirect immunofluorescence of normal skin also did not detect any antibodies. Consequently, we made a final diagnosis of oral LP<\/jats:styled-content>. The previous two LP<\/jats:styled-content> cases with positive ELISA<\/jats:styled-content> for DSG<\/jats:styled-content> antibodies and our case manifested the erosive form, the most advanced oral LP<\/jats:styled-content>. Therefore, it is a possibility that severe damage of keratinocytes may induce generation of DSG<\/jats:styled-content> antibodies. However, negative results of immunofluorescence and no relation between disease severity and titers of antibodies make the possibility unlikely. We should measure titers of DSG<\/jats:styled-content> antibodies in LP<\/jats:styled-content> patients and accumulate data to establish a valid conclusion.<\/jats:p>","DOI":"10.1111\/1346-8138.12661","type":"journal-article","created":{"date-parts":[[2014,10,30]],"date-time":"2014-10-30T06:15:54Z","timestamp":1414649754000},"page":"40-41","source":"Crossref","is-referenced-by-count":13,"title":["Oral lichen planus with antibodies to desmogleins 1 and 3"],"prefix":"10.1111","volume":"42","author":[{"given":"Chihiro","family":"Kinjyo","sequence":"first","affiliation":[{"name":"Department of Dermatology Hirosaki University Graduate School of Medicine Hirosaki Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takahide","family":"Kaneko","sequence":"additional","affiliation":[{"name":"Department of Dermatology Hirosaki University Graduate School of Medicine Hirosaki Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ayumi","family":"Korekawa","sequence":"additional","affiliation":[{"name":"Department of Dermatology Hirosaki University Graduate School of Medicine Hirosaki Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akiko","family":"Rokunohe","sequence":"additional","affiliation":[{"name":"Department of Dermatology Hirosaki University Graduate School of Medicine Hirosaki Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takayuki","family":"Aizu","sequence":"additional","affiliation":[{"name":"Department of Dermatology Hirosaki University Graduate School of Medicine Hirosaki Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasushi","family":"Matsuzaki","sequence":"additional","affiliation":[{"name":"Department of Dermatology Hirosaki University Graduate School of Medicine Hirosaki Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hajime","family":"Nakano","sequence":"additional","affiliation":[{"name":"Department of Dermatology Hirosaki University Graduate School of Medicine Hirosaki Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daisuke","family":"Sawamura","sequence":"additional","affiliation":[{"name":"Department of Dermatology Hirosaki University Graduate School of Medicine Hirosaki Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,10,30]]},"reference":[{"key":"e_1_2_5_2_1","first-page":"494","article-title":"Oral lichen planus: clinical presentation and management","volume":"68","author":"Edwards PC","year":"2002","journal-title":"J Can Dent Assoc"},{"key":"e_1_2_5_3_1","first-page":"741","article-title":"A case of oral lichen planus showing antibodies for desmoglein 1 and BP180 NC16a","volume":"47","author":"Kishimoto K","year":"2005","journal-title":"Rinsho Derma"},{"key":"e_1_2_5_4_1","first-page":"173","article-title":"A case of oral lichen planus in a patient with anti\u2010desmoglein antibodies","volume":"8","author":"Kato T","year":"2009","journal-title":"Skin Research"},{"key":"e_1_2_5_5_1","first-page":"53","article-title":"Serum autoantibodies to desmogleins 1 and 3 in patients with oral lichen planus","volume":"47","author":"Lukac J","year":"2006","journal-title":"Croat Med J"}],"container-title":["The Journal of Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2F1346-8138.12661","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1346-8138.12661","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,14]],"date-time":"2023-09-14T00:23:36Z","timestamp":1694651016000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/1346-8138.12661"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,10,30]]},"references-count":4,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2015,1]]}},"alternative-id":["10.1111\/1346-8138.12661"],"URL":"https:\/\/doi.org\/10.1111\/1346-8138.12661","archive":["Portico"],"relation":{},"ISSN":["0385-2407","1346-8138"],"issn-type":[{"value":"0385-2407","type":"print"},{"value":"1346-8138","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,10,30]]}}}