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Recent advances in pharmacogenomic studies have provided evidence of genetic predispositions to\n                    <jats:styled-content style=\"fixed-case\">SJS<\/jats:styled-content>\n                    \/\n                    <jats:styled-content style=\"fixed-case\">TEN<\/jats:styled-content>\n                    . Several concepts have been proposed to explain the pathogenesis of severe cutaneous adverse drug reactions. In the hapten concept, small molecules called haptens elicit an immune response only when attached to proteins. The \u201cp\u2010i\u201d concept postulates that the causative drugs can stimulate cells by binding directly and reversibly to immune receptors. In addition, there is the idea that drugs alter the antigen by binding to the human leukocyte antigen pocket. With regard to keratinocyte death, several cell death mediators, such as\n                    <jats:styled-content style=\"fixed-case\">F<\/jats:styled-content>\n                    as\n                    <jats:styled-content style=\"fixed-case\">L<\/jats:styled-content>\n                    , granulysin and annexin\n                    <jats:styled-content style=\"fixed-case\">A<\/jats:styled-content>\n                    1, have been proposed as playing a role in\n                    <jats:styled-content style=\"fixed-case\">SJS<\/jats:styled-content>\n                    \/\n                    <jats:styled-content style=\"fixed-case\">TEN<\/jats:styled-content>\n                    pathogenesis. A subset of\n                    <jats:styled-content style=\"fixed-case\">T<\/jats:styled-content>\n                    lymphocytes, including regulatory\n                    <jats:styled-content style=\"fixed-case\">T<\/jats:styled-content>\n                    cells, also may play a role in\n                    <jats:styled-content style=\"fixed-case\">SJS<\/jats:styled-content>\n                    \/\n                    <jats:styled-content style=\"fixed-case\">TEN<\/jats:styled-content>\n                    .\n                  <\/jats:p>","DOI":"10.1111\/1346-8138.12674","type":"journal-article","created":{"date-parts":[[2014,10,30]],"date-time":"2014-10-30T02:59:30Z","timestamp":1414637970000},"page":"42-48","source":"Crossref","is-referenced-by-count":45,"title":["Immunological response in Stevens\u2013Johnson syndrome and toxic epidermal 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