{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,9,24]],"date-time":"2023-09-24T17:40:59Z","timestamp":1695577259760},"reference-count":12,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2014,11,11]],"date-time":"2014-11-11T00:00:00Z","timestamp":1415664000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Journal of Dermatology"],"published-print":{"date-parts":[[2014,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Cutaneous squamous cell carcinoma (c<jats:styled-content style=\"fixed-case\">SCC<\/jats:styled-content>) and actinic keratosis (AK) occur most often on the face. Ultraviolet light is apparently their most common cause. As AK is considered to be a precursor of c<jats:styled-content style=\"fixed-case\">SCC<\/jats:styled-content>, their distribution on the face should be similar. However, c<jats:styled-content style=\"fixed-case\">SCC<\/jats:styled-content> often occurs on the temple or mandibular area, whereas AK arises on the central forehead, cheek or nose. We retrospectively evaluated differences in affected site distribution for c<jats:styled-content style=\"fixed-case\">SCC<\/jats:styled-content> (<jats:italic>n\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>54) and AK (<jats:italic>n\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>95). We found AK to occur preferentially on the central facial area (63\/95, 66%), which is the most sun\u2010exposed area, and c<jats:styled-content style=\"fixed-case\">SCC<\/jats:styled-content> to occur preferentially on peripheral areas such as the temple and mandibular area (24\/54, 44%). Those distributions were significantly different (<jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.011, Fisher's exact test). This result suggests that c<jats:styled-content style=\"fixed-case\">SCC<\/jats:styled-content> occurs preferentially in the peripheral area compared with the central facial area, which further implies that either other factors are needed to make AK progress to c<jats:styled-content style=\"fixed-case\">SCC<\/jats:styled-content> in peripheral areas, or that peripheral c<jats:styled-content style=\"fixed-case\">SCC<\/jats:styled-content> can occur without preceding AK. This is the first report to focus on geographic assessment of c<jats:styled-content style=\"fixed-case\">SCC<\/jats:styled-content> and AK in detail. Further studies are needed to elucidate the mechanism of our finding.<\/jats:p>","DOI":"10.1111\/1346-8138.12679","type":"journal-article","created":{"date-parts":[[2014,11,11]],"date-time":"2014-11-11T07:26:05Z","timestamp":1415690765000},"page":"1102-1105","source":"Crossref","is-referenced-by-count":4,"title":["Comparison of facial predilection sites for cutaneous squamous cell carcinoma and actinic keratosis in Japanese patients"],"prefix":"10.1111","volume":"41","author":[{"given":"Yoshitsugu","family":"Shibayama","sequence":"first","affiliation":[{"name":"Department of Dermatology Faculty of Medicine Fukuoka University  Fukuoka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shinichi","family":"Imafuku","sequence":"additional","affiliation":[{"name":"Department of Dermatology Faculty of Medicine Fukuoka University  Fukuoka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,11,11]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199212033272307"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2012.09.053"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.2013.760"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.2011.39"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-3835(01)00757-1"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.5227\/skincancer.9.Special_99"},{"key":"e_1_2_6_8_1","first-page":"29","article-title":"A clinicopathological study of primary cutaneous squamous cell carcinoma","volume":"118","author":"Anzai S","year":"2008","journal-title":"Jpn J Dermatol"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.24284"},{"key":"e_1_2_6_10_1","first-page":"54","article-title":"Measure and influence of UV ray irradiation on different regions of face skin","volume":"4","author":"Miyazawa M","year":"2004","journal-title":"Fragr J"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/jidsymp.2009.4"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.dld.2012.10.020"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjc.6603579"}],"container-title":["The Journal of Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2F1346-8138.12679","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1346-8138.12679","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,24]],"date-time":"2023-09-24T17:09:03Z","timestamp":1695575343000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/1346-8138.12679"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,11,11]]},"references-count":12,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2014,12]]}},"alternative-id":["10.1111\/1346-8138.12679"],"URL":"https:\/\/doi.org\/10.1111\/1346-8138.12679","archive":["Portico"],"relation":{},"ISSN":["0385-2407","1346-8138"],"issn-type":[{"value":"0385-2407","type":"print"},{"value":"1346-8138","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,11,11]]}}}