{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,22]],"date-time":"2026-06-22T13:36:43Z","timestamp":1782135403635,"version":"3.54.5"},"reference-count":21,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2014,11,12]],"date-time":"2014-11-12T00:00:00Z","timestamp":1415750400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Journal of Dermatology"],"published-print":{"date-parts":[[2015,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Doxycycline is the standard systemic treatment for rosacea. Recently, there have been a few reports on \u03b2\u2010adrenergic blockers such as nadolol, carvedilol and propranolol for suppressing flushing reactions in rosacea. To our knowledge, there are no comparative studies of propranolol and doxycycline, and combination therapy using both. The aim of this study was to investigate and compare the efficacy and safety of monotherapy of propranolol, doxycycline and combination therapy. A total of 78 patients who visited Pusan National University Hospital and were diagnosed with rosacea were included in this study. Among them, 28 patients were in the propranolol group, 22 the doxycycline group and 28 the combination group. We investigated the patient global assessment (PGA), investigator global assessment (IGA), assessment of rosacea clinical score (ARCS) and adverse effects. Improvement in PGA and IGA scores from baseline was noted in all groups, and the combination therapy was found to be the most effective during the entire period, but this was statistically insignificant. The reduction rate of ARCS during the treatment period was also highest in the combination group (57.4%), followed by the doxycycline group (52.2%) and the propranolol group (51.0%). Three patients in the combination group had mild and transient gastrointestinal disturbances but there was no significant difference from the other groups. We conclude that the combination therapy of doxycycline and propranolol is effective and safe treatment for rosacea and successful for reducing both flushing and papulation in particular.<\/jats:p>","DOI":"10.1111\/1346-8138.12687","type":"journal-article","created":{"date-parts":[[2014,11,12]],"date-time":"2014-11-12T05:46:03Z","timestamp":1415771163000},"page":"64-69","source":"Crossref","is-referenced-by-count":24,"title":["Propranolol, doxycycline and combination therapy for the treatment of rosacea"],"prefix":"10.1111","volume":"42","author":[{"given":"Jung\u2010Min","family":"Park","sequence":"first","affiliation":[{"name":"Department of Dermatology School of Medicine Pusan National University Busan Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Je\u2010Ho","family":"Mun","sequence":"additional","affiliation":[{"name":"Department of Dermatology School of Medicine Pusan National University Busan Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margaret","family":"Song","sequence":"additional","affiliation":[{"name":"Department of Dermatology School of Medicine Pusan National University Busan Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hoon\u2010Soo","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Dermatology School of Medicine Pusan National University Busan Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Byung\u2010Soo","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Dermatology School of Medicine Pusan National University Busan Korea"},{"name":"Biomedical Research Institute Pusan National University Hospital Busan Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Moon\u2010Bum","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Dermatology School of Medicine Pusan National University Busan Korea"},{"name":"Biomedical Research Institute Pusan National University Hospital Busan Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyun\u2010Chang","family":"Ko","sequence":"additional","affiliation":[{"name":"Department of Dermatology School of Medicine Pusan National University Busan Korea"},{"name":"Research Institute for Convergence of Biomedical Science and Technology Pusan National University Yangsan Hospital Busan Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,11,12]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMcp042829"},{"key":"e_1_2_6_3_1","first-page":"419","article-title":"An epidemiological study of rosacea","volume":"69","author":"Berg M","year":"1989","journal-title":"Acta Derm Venereol"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1067\/mjd.2002.120625"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2004.01.048"},{"key":"e_1_2_6_6_1","first-page":"121","article-title":"Rosacea: clinical aspects, pathogenesis and treatment","volume":"23","author":"Lee JY","year":"2005","journal-title":"Dermatol Sinica"},{"key":"e_1_2_6_7_1","first-page":"129","article-title":"Safety and efficacy of doxycycline in the treatment of rosacea","volume":"2","author":"Valent\u00edn S","year":"2009","journal-title":"Clin Cosmet Investig Dermatol"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2005.07.021"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1001\/archdermatol.2011.204"},{"key":"e_1_2_6_10_1","first-page":"135","article-title":"Niacinamide\u2010containing facial moisturizer improves skin barrier and benefits subjects with rosacea","volume":"76","author":"Draelos ZD","year":"2005","journal-title":"Cutis"},{"key":"e_1_2_6_11_1","first-page":"495","article-title":"Managing rosacea: a review of the use of metronidazole alone and in combination with oral antibiotics","volume":"6","author":"Conde JF","year":"2007","journal-title":"J Drugs Dermatol"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1080\/09546630701485233"},{"key":"e_1_2_6_13_1","first-page":"636","article-title":"A clinical study of 112 patients with rosacea","volume":"39","author":"Lee SY","year":"2001","journal-title":"Korean J Dermatol"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2230.2003.01179.x"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.2165\/11530200-000000000-00000"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2005.10.004"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.det.2007.01.012"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2012.04.017"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.103.058032"},{"key":"e_1_2_6_20_1","first-page":"17","article-title":"Reactive oxygen species and rosacea","volume":"74","author":"Jones D","year":"2004","journal-title":"Cutis"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12019-007-8003-x"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.1994.01690030051008"}],"container-title":["The Journal of Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2F1346-8138.12687","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1346-8138.12687","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,14]],"date-time":"2023-09-14T00:22:17Z","timestamp":1694650937000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/1346-8138.12687"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,11,12]]},"references-count":21,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2015,1]]}},"alternative-id":["10.1111\/1346-8138.12687"],"URL":"https:\/\/doi.org\/10.1111\/1346-8138.12687","archive":["Portico"],"relation":{},"ISSN":["0385-2407","1346-8138"],"issn-type":[{"value":"0385-2407","type":"print"},{"value":"1346-8138","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,11,12]]}}}