{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,8,31]],"date-time":"2024-08-31T21:51:07Z","timestamp":1725141067998},"reference-count":23,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2014,12,1]],"date-time":"2014-12-01T00:00:00Z","timestamp":1417392000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Journal of Dermatology"],"published-print":{"date-parts":[[2014,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Molluscum contagiosum (MC) may persist for many weeks, evading host immunity. We studied the mechanism of immune escape phenomenon in MC, and the possible inducer of apoptosis. Using tissue samples of MC, we examined the numbers of epidermal Langerhans cells (LC), the expression levels of macrophage inflammatory protein\u20103\u03b1 (MIP\u20103\u03b1) and thymic stromal lymphopoietin (TSLP), and the apoptotic signals. After molluscum contagiosum virus (MCV) genotyping, we studied the expression of MCV\u2010encoded MC148 mRNA and MC159 mRNA which correspond to viral antagonist for CCR8 and viral Fas\u2010linked interleukin (IL)\u20101\u03b2 converting enzyme (FLICE)\u2010like inhibitor protein (<jats:styled-content style=\"fixed-case\">vFLIP<\/jats:styled-content>), respectively. The nutlin\u20103\u2010induced apoptosis in MC was observed <jats:italic>ex vivo<\/jats:italic>. The numbers of CD1a<jats:sup>+<\/jats:sup> or Langerin<jats:sup>+<\/jats:sup> epidermal LC and the expression levels of MIP\u20103\u03b1 were markedly decreased in MC. The expression of TSLP was enhanced in the lesional epidermis of atopic dermatitis and human papillomavirus\u2010induced warts, whereas the expression was observed locally in MC. All 14 MC samples examined harbored MCV type 1. The MC148 mRNA was detected in all 14 samples and the MC159 <jats:styled-content style=\"fixed-case\">mRNA<\/jats:styled-content> was detected in 13 samples. Apoptotic cells were absent or at a background level in the living layers of MC, but their numbers were increased in the molluscum bodies by overnight incubation with 5\u00a0\u03bcmol\/L nutlin\u20103 in culture medium. In conclusion, molluscum bodies are protected from host immune responses and apoptotic signals by being surrounded by LC\u2010depleted epidermal walls and viral immunosuppressive molecules, but could be eradicated by reagents inducing p53\u2010dependent apoptosis.<\/jats:p>","DOI":"10.1111\/1346-8138.12695","type":"journal-article","created":{"date-parts":[[2014,12,1]],"date-time":"2014-12-01T07:30:27Z","timestamp":1417419027000},"page":"1058-1064","source":"Crossref","is-referenced-by-count":3,"title":["Immune escape phenomenon in molluscum contagiosum and the induction of apoptosis"],"prefix":"10.1111","volume":"41","author":[{"given":"Akiko","family":"Yamauchi\u2010Yamada","sequence":"first","affiliation":[{"name":"Department of Dermatology Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences Okayama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takenobu","family":"Yamamoto","sequence":"additional","affiliation":[{"name":"Department of Dermatology Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences Okayama Japan"},{"name":"Kawasaki Hospital Kawasaki Medical College Okayama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yumi","family":"Nakayama","sequence":"additional","affiliation":[{"name":"Department of Dermatology Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences Okayama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazuko","family":"Ikeda","sequence":"additional","affiliation":[{"name":"Department of Dermatology Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences Okayama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomoko","family":"Miyake","sequence":"additional","affiliation":[{"name":"Department of Dermatology Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences Okayama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mari","family":"Yamaguchi","sequence":"additional","affiliation":[{"name":"Department of Dermatology Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences Okayama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoji","family":"Hirai","sequence":"additional","affiliation":[{"name":"Department of Dermatology Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences Okayama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshinori","family":"Shirafuji","sequence":"additional","affiliation":[{"name":"Department of Dermatology Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences Okayama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shin","family":"Morizane","sequence":"additional","affiliation":[{"name":"Department of Dermatology Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences Okayama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yumi","family":"Aoyama","sequence":"additional","affiliation":[{"name":"Department of Dermatology Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences Okayama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keiji","family":"Iwatsuki","sequence":"additional","affiliation":[{"name":"Department of Dermatology Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences Okayama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,12]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.1949.99"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19850515)55:10<2437::AID-CNCR2820551023>3.0.CO;2-Z"},{"issue":"6","key":"e_1_2_7_4_1","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1001\/archderm.1986.01660180061015","article-title":"Plane warts under spontaneous regression","volume":"122","author":"Iwatsuki K","year":"1986","journal-title":"Arch Dermatol"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0190-9622(86)70219-3"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdermsci.2011.05.006"},{"issue":"40","key":"e_1_2_7_7_1","doi-asserted-by":"crossref","first-page":"37647","DOI":"10.1074\/jbc.M203907200","article-title":"The structure of human macrophage inflammatory protein\u20103\u03b1\/CCL20","volume":"277","author":"David MH","year":"2002","journal-title":"J Biol Chem"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2006.10.005"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.79.23.14852-14862.2005"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20041503"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni.1852"},{"issue":"1","key":"e_1_2_7_12_1","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1084\/jem.191.1.171","article-title":"A highly selective CC chemokine receptor (CCR)8 antagonist encoded by the poxvirus molluscum contagiosum","volume":"191","author":"Hans RL","year":"2000","journal-title":"J Exp Med"},{"key":"e_1_2_7_13_1","first-page":"272","article-title":"MC148 encoded by human molluscum contagiosum poxvirus is an antagonist for human but not murine CCR8","volume":"70","author":"Hans RL","year":"2001","journal-title":"J Leuko Biol"},{"key":"e_1_2_7_14_1","first-page":"14","article-title":"Molluscum contagiosum virus inhibitor of apotosis: the MCV159 v\u2010FLIP protein blocks fas\u2010induced activation of procaspases and degeneration of the related MC160 protein","volume":"282","author":"Joanna L","year":"2001","journal-title":"Vilorogy"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.virol.2005.06.036"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1092472"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-9071(199711)53:3<205::AID-JMV4>3.0.CO;2-C"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gng154"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1177\/002215549904700402"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.gt.3301128"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.172.10.6313"},{"key":"e_1_2_7_22_1","first-page":"25","article-title":"A newly identified single nucleotide polymorphism in the promoter of the matrix metalloproteinase\u20101gene","volume":"16","author":"Jurajada M","year":"2002","journal-title":"Mol Cell Probes"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00370727"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2010.256"}],"container-title":["The Journal of Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2F1346-8138.12695","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1346-8138.12695","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,24]],"date-time":"2023-09-24T17:07:56Z","timestamp":1695575276000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/1346-8138.12695"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,12]]},"references-count":23,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2014,12]]}},"alternative-id":["10.1111\/1346-8138.12695"],"URL":"https:\/\/doi.org\/10.1111\/1346-8138.12695","archive":["Portico"],"relation":{},"ISSN":["0385-2407","1346-8138"],"issn-type":[{"value":"0385-2407","type":"print"},{"value":"1346-8138","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,12]]}}}