{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T05:15:10Z","timestamp":1761110110720,"version":"3.40.5"},"reference-count":30,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2014,11,12]],"date-time":"2014-11-12T00:00:00Z","timestamp":1415750400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Journal of Dermatology"],"published-print":{"date-parts":[[2014,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Autoimmune thyroid disorders (<jats:styled-content style=\"fixed-case\">AITD<\/jats:styled-content>) are characterized by the impairment of the thyroid gland as a result of systemic or organ\u2010specific autoimmune disorders, and the presence of antithyroid autoantibodies, such as antithyroglobulin antibody (<jats:styled-content style=\"fixed-case\">A<\/jats:styled-content>b<jats:styled-content style=\"fixed-case\">T<\/jats:styled-content>g) and antithyroid peroxidase antibody (<jats:styled-content style=\"fixed-case\">A<\/jats:styled-content>b<jats:styled-content style=\"fixed-case\">TPO<\/jats:styled-content>). Several studies have reported the association of<jats:styled-content style=\"fixed-case\">AITD<\/jats:styled-content>with systemic sclerosis (<jats:styled-content style=\"fixed-case\">SS<\/jats:styled-content>c). However, none of those studies analyzed the association between<jats:styled-content style=\"fixed-case\">AITD<\/jats:styled-content>and skin sclerosis in<jats:styled-content style=\"fixed-case\">SS<\/jats:styled-content>c patients. The aim of this study was to examine the demographic and clinical features of<jats:styled-content style=\"fixed-case\">SS<\/jats:styled-content>c patients with<jats:styled-content style=\"fixed-case\">AITD<\/jats:styled-content>treated in our department. Of a total of 210<jats:styled-content style=\"fixed-case\">SS<\/jats:styled-content>c patients, we identified 30 with<jats:styled-content style=\"fixed-case\">AITD<\/jats:styled-content>(14.3%), including 29 with<jats:styled-content style=\"fixed-case\">H<\/jats:styled-content>ashimoto's disease (13.8%) and one patient with<jats:styled-content style=\"fixed-case\">G<\/jats:styled-content>raves' disease (0.5%), indicating that hypothyroidism was more common among<jats:styled-content style=\"fixed-case\">SS<\/jats:styled-content>c patients with<jats:styled-content style=\"fixed-case\">AITD<\/jats:styled-content>. All patients with<jats:styled-content style=\"fixed-case\">AITD<\/jats:styled-content>were female, and anticentromere antibody positivity, the complication of<jats:styled-content style=\"fixed-case\">S<\/jats:styled-content>j\u00f6gren's syndrome, severe facial skin sclerosis and atrophy of the thyroid gland were significantly prevalent in<jats:styled-content style=\"fixed-case\">SS<\/jats:styled-content>c patients with<jats:styled-content style=\"fixed-case\">AITD<\/jats:styled-content>.<jats:styled-content style=\"fixed-case\">SS<\/jats:styled-content>c patients with such clinical features may be at high risk of<jats:styled-content style=\"fixed-case\">AITD<\/jats:styled-content>and require regular follow up of thyroid function including ultrasonography and the examination of serum hormone levels to start an early treatment.<\/jats:p>","DOI":"10.1111\/1346-8138.12698","type":"journal-article","created":{"date-parts":[[2014,11,12]],"date-time":"2014-11-12T07:39:10Z","timestamp":1415777950000},"page":"1053-1057","source":"Crossref","is-referenced-by-count":14,"title":["Demographic and clinical features of autoimmune thyroid disorder in<scp>J<\/scp>apanese patients with systemic sclerosis"],"prefix":"10.1111","volume":"41","author":[{"given":"Sayaka","family":"Toki","sequence":"first","affiliation":[{"name":"Department of Dermatology Gunma University Graduate School of Medicine Maebashi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sei\u2010ichiro","family":"Motegi","sequence":"additional","affiliation":[{"name":"Department of Dermatology Gunma University Graduate School of Medicine Maebashi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazuya","family":"Yamada","sequence":"additional","affiliation":[{"name":"Department of Dermatology Gunma University Graduate School of Medicine Maebashi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akihiko","family":"Uchiyama","sequence":"additional","affiliation":[{"name":"Department of Dermatology Gunma University Graduate School of Medicine Maebashi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Osamu","family":"Ishikawa","sequence":"additional","affiliation":[{"name":"Department of Dermatology Gunma University Graduate School of Medicine Maebashi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,11,12]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"crossref","first-page":"394","DOI":"10.20452\/pamw.1829","article-title":"Relationship between rheumatoid arthritis activity and antithyroid antibodies","volume":"123","author":"Koszarny A","year":"2013","journal-title":"Pol Arch Med Wewn"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.metabol.2009.10.010"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/RHU.0b013e31819dbe4c"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmii.2014.03.004"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10067-007-0638-6"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(69)90044-8"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-95-4-431"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00406692"},{"key":"e_1_2_6_10_1","doi-asserted-by":"crossref","first-page":"35","DOI":"10.2340\/00015555663538","article-title":"Thyroid hormones in generalized scleroderma. 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