{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,9,23]],"date-time":"2023-09-23T21:06:33Z","timestamp":1695503193301},"reference-count":16,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2014,11,26]],"date-time":"2014-11-26T00:00:00Z","timestamp":1416960000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Journal of Dermatology"],"published-print":{"date-parts":[[2015,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Because psoriatic skin lesions of psoriatic arthritis (PsA) usually precede the onset of joint symptom, dermatologists are in an ideal position to screen and find individuals with PsA early in the disease course. There have been no reports from the dermatology field evaluating the effect of anti\u2010tumor necrosis factor (<jats:styled-content style=\"fixed-case\">TNF<\/jats:styled-content>)\u2010\u03b1 drugs on joint disorders using magnetic resonance imaging (<jats:styled-content style=\"fixed-case\">MRI<\/jats:styled-content>) in PsA patients. The purpose of this study was to elucidate the effectiveness of <jats:styled-content style=\"fixed-case\">MRI<\/jats:styled-content> in the evaluation of anti\u2010<jats:styled-content style=\"fixed-case\">TNF<\/jats:styled-content>\u2010\u03b1 drugs on joint disease of Japanese PsA patients. Data were collected from four adult Japanese male PsA patients. <jats:styled-content style=\"fixed-case\">MRI<\/jats:styled-content> of the affected hand was performed at baseline and 1\u20137\u00a0months after infliximab or adalimumab treatment. T<jats:sub>1<\/jats:sub>\u2010weighted gadolinium\u2010enhanced images with fat suppression were acquired in the coronal, sagittal and\/or axial planes. We determined the apparent improvement of synovitis, periarticular inflammation, tenosynovitis and\/or bone marrow edema by <jats:styled-content style=\"fixed-case\">MRI<\/jats:styled-content> after anti\u2010<jats:styled-content style=\"fixed-case\">TNF<\/jats:styled-content>\u2010\u03b1 treatments in all the patients together with the improvement of skin lesions. We also determined in one patient that these symptoms detected by <jats:styled-content style=\"fixed-case\">MRI<\/jats:styled-content> before treatment were alleviated within 1\u00a0month and had disappeared 6\u00a0months after treatment, suggesting the potentially early detection of the effect of anti\u2010<jats:styled-content style=\"fixed-case\">TNF<\/jats:styled-content>\u2010\u03b1 drugs on joint disease. We present four cases of Japanese patients with PsA in whom effective treatments by anti\u2010<jats:styled-content style=\"fixed-case\">TNF<\/jats:styled-content>\u2010\u03b1 drugs were evaluated by contrast\u2010enhanced <jats:styled-content style=\"fixed-case\">MRI<\/jats:styled-content>. This imaging enables dermatologists and radiologists to assess and monitor early inflammatory changes, and to grant PsA patients earlier access to modern treatment such as biologics.<\/jats:p>","DOI":"10.1111\/1346-8138.12708","type":"journal-article","created":{"date-parts":[[2014,11,26]],"date-time":"2014-11-26T06:21:23Z","timestamp":1416982883000},"page":"49-55","source":"Crossref","is-referenced-by-count":4,"title":["Four cases of Japanese patients with psoriatic arthritis in whom effective treatments by anti\u2010tumor necrosis factor\u2010\u03b1 drugs were evaluated by magnetic resonance imaging together with improvement of skin lesions"],"prefix":"10.1111","volume":"42","author":[{"given":"Takenori","family":"Yonenaga","sequence":"first","affiliation":[{"name":"Department of Radiology The Jikei University School of Medicine Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hidehisa","family":"Saeki","sequence":"additional","affiliation":[{"name":"Department of Dermatology Nippon Medical School Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hidemi","family":"Nakagawa","sequence":"additional","affiliation":[{"name":"Department of Dermatology The Jikei University School of Medicine Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Osamu","family":"Fukuchi","sequence":"additional","affiliation":[{"name":"Department of Dermatology The Jikei University School of Medicine Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshinori","family":"Umezawa","sequence":"additional","affiliation":[{"name":"Department of Dermatology The Jikei University School of Medicine Tokyo 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Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kunihiko","family":"Fukuda","sequence":"additional","affiliation":[{"name":"Department of Radiology The Jikei University School of Medicine Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,11,26]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.12659\/PJR.883763"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.120249"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2005.03.046"},{"key":"e_1_2_6_5_1","first-page":"1423","article-title":"Psoriatic arthritis screeing tools","volume":"35","author":"Qureshi AA","year":"2008","journal-title":"J 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