{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T23:48:01Z","timestamp":1767916081176,"version":"3.49.0"},"reference-count":18,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2014,12,12]],"date-time":"2014-12-12T00:00:00Z","timestamp":1418342400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100010084","name":"Independent Innovation Foundation of Shandong University","doi-asserted-by":"crossref","award":["IIFSDU, 2012DX003"],"award-info":[{"award-number":["IIFSDU, 2012DX003"]}],"id":[{"id":"10.13039\/501100010084","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100007129","name":"Shandong Provincial Natural Science Foundation","doi-asserted-by":"crossref","award":["Y2008C78"],"award-info":[{"award-number":["Y2008C78"]}],"id":[{"id":"10.13039\/501100007129","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Journal of Dermatology"],"published-print":{"date-parts":[[2015,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Vitiligo is a common depigmentary skin disease that may follow a pattern of multifactorial inheritance. The essential factors of its immunopathogenesis is thought to be the selective destruction of melanocytes. As a new class of microregulators of gene expression, mi<jats:styled-content style=\"fixed-case\">RNA<\/jats:styled-content> have been reported to play vital roles in autoimmune diseases, metabolic diseases and cancer. This study sought to characterize the different mi<jats:styled-content style=\"fixed-case\">RNA<\/jats:styled-content> expression pattern in the peripheral blood mononuclear cells (<jats:styled-content style=\"fixed-case\">PBMC<\/jats:styled-content>) of patients with non\u2010segmental vitiligo (<jats:styled-content style=\"fixed-case\">NSV<\/jats:styled-content>) and healthy individuals and to examine their direct responses to thymosin \u03b11 (T\u03b11) treatment. The mi<jats:styled-content style=\"fixed-case\">RNA<\/jats:styled-content> expression profile in the <jats:styled-content style=\"fixed-case\">PBMC<\/jats:styled-content> of patients with <jats:styled-content style=\"fixed-case\">NSV<\/jats:styled-content> was analyzed using Exiqon's miRCURY LNA microRNA Array. The differentially expressed mi<jats:styled-content style=\"fixed-case\">RNA<\/jats:styled-content> were validated by real\u2010time quantitative polymerase chain reaction. We found that the expression levels of miR\u2010224\u20103p and miR\u20104712\u20103p were upregulated, and miR\u20103940\u20105p was downregulated in the <jats:styled-content style=\"fixed-case\">PBMC<\/jats:styled-content>. The common clinical immune modulator T\u03b11 changed the mi<jats:styled-content style=\"fixed-case\">RNA<\/jats:styled-content> expression profile. Our analysis showed that differentially expressed mi<jats:styled-content style=\"fixed-case\">RNA<\/jats:styled-content> were associated with the mechanism of immune imbalance of vitiligo and that T\u03b11 could play an important role in changing the expression of these mi<jats:styled-content style=\"fixed-case\">RNA<\/jats:styled-content> in the <jats:styled-content style=\"fixed-case\">PBMC<\/jats:styled-content> of patients with <jats:styled-content style=\"fixed-case\">NSV<\/jats:styled-content>. This study provided further evidence that mi<jats:styled-content style=\"fixed-case\">RNA<\/jats:styled-content> may serve as novel drug targets for vitiligo therapeutic evaluation.<\/jats:p>","DOI":"10.1111\/1346-8138.12725","type":"journal-article","created":{"date-parts":[[2014,12,12]],"date-time":"2014-12-12T05:38:17Z","timestamp":1418362697000},"page":"193-197","source":"Crossref","is-referenced-by-count":41,"title":["Differential expression analysis of mi<scp>RNA<\/scp> in peripheral blood mononuclear cells of patients with non\u2010segmental vitiligo"],"prefix":"10.1111","volume":"42","author":[{"given":"Yi","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Dermatology Qilu Hospital Shandong University Jinan China"},{"name":"Department of Dermatology Jinan Central Hospital Affiliated to Shandong University Jinan 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Jinan Central Hospital Affiliated to Shandong University Jinan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yi","family":"Kong","sequence":"additional","affiliation":[{"name":"Department of Dermatology Jinan Central Hospital Affiliated to Shandong University Jinan 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