{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,13]],"date-time":"2025-10-13T19:56:32Z","timestamp":1760385392961},"reference-count":8,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2014,12,10]],"date-time":"2014-12-10T00:00:00Z","timestamp":1418169600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Journal of Dermatology"],"published-print":{"date-parts":[[2015,1]]},"abstract":"Abstract<\/jats:title>As a novel method improving the safety of conventional oral ivermectin (IVM<\/jats:styled-content>) for scabies treatment, we conceived an idea called the \u201cwhole\u2010body bathing method\u201d. In this method, the patients would bathe themselves in a bathing fluid containing IVM<\/jats:styled-content> at an effective concentration. To evaluate the feasibility of the method, we investigated the IVM<\/jats:styled-content> concentration in the skin and plasma after bathing rats in a fluid containing 100\u00a0ng\/mL of IVM<\/jats:styled-content>. After the bathing, the concentration of IVM<\/jats:styled-content> in the skin was more than 400\u00a0ng\/g wet weight and was maintained until 8\u00a0h after the bathing. The concentration was clearly higher than that in patients taking IVM<\/jats:styled-content> p.o. as previously reported; IVM<\/jats:styled-content> was not detected in plasma in the present study. Thus, the method would be a preferable drug delivery system for the skin application of IVM<\/jats:styled-content> compared with p.o. administration.<\/jats:p>","DOI":"10.1111\/1346-8138.12728","type":"journal-article","created":{"date-parts":[[2014,12,10]],"date-time":"2014-12-10T06:11:29Z","timestamp":1418191889000},"page":"87-89","source":"Crossref","is-referenced-by-count":10,"title":["Experimental study of pharmacokinetics of external, whole\u2010body bathing application of ivermectin"],"prefix":"10.1111","volume":"42","author":[{"given":"Atsushi","family":"Miyajima","sequence":"first","affiliation":[{"name":"Department of Biopharmaceutics Faculty of Pharmaceutical Sciences Tokyo University of Science Noda\u2010shi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masayo","family":"Komoda","sequence":"additional","affiliation":[{"name":"Department of Medical Safety Faculty of Pharmaceutical Sciences Tokyo University of Science Noda\u2010shi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keita","family":"Akagi","sequence":"additional","affiliation":[{"name":"Department of Medical Safety Faculty of Pharmaceutical Sciences Tokyo University of Science Noda\u2010shi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kaoru","family":"Yuzawa","sequence":"additional","affiliation":[{"name":"Department of Medical Safety Faculty of Pharmaceutical Sciences Tokyo University of Science Noda\u2010shi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takashi","family":"Yoshimasu","sequence":"additional","affiliation":[{"name":"Department of Medical Safety Faculty of Pharmaceutical Sciences Tokyo University of Science Noda\u2010shi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yosuke","family":"Yamamoto","sequence":"additional","affiliation":[{"name":"Department of Biopharmaceutics Faculty of Pharmaceutical Sciences Tokyo University of Science Noda\u2010shi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takashi","family":"Hirota","sequence":"additional","affiliation":[{"name":"Department of Biopharmaceutics Faculty of Pharmaceutical Sciences Tokyo University of Science Noda\u2010shi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,12,10]]},"reference":[{"key":"e_1_2_7_2_1","first-page":"1","article-title":"Interventions for treating scabies","volume":"2","author":"Strong M","year":"2010","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1346-8138.2009.00691.x"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10096-012-1752-1"},{"key":"e_1_2_7_5_1","doi-asserted-by":"crossref","DOI":"10.2807\/ese.13.48.19052-en","article-title":"A persistent problem with scabies in and outside a nursing home in Amsterdam: indications for resistance to lindane and ivermectin","volume":"13","author":"van den Hoek JA","year":"2008","journal-title":"Euro Surveill"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajic.2011.05.014"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/QCO.0b013e32835e1d57"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMct0910329"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.138.12.1618"}],"container-title":["The Journal of Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2F1346-8138.12728","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1346-8138.12728","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,14]],"date-time":"2023-09-14T00:23:44Z","timestamp":1694651024000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/1346-8138.12728"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,12,10]]},"references-count":8,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2015,1]]}},"alternative-id":["10.1111\/1346-8138.12728"],"URL":"https:\/\/doi.org\/10.1111\/1346-8138.12728","archive":["Portico"],"relation":{},"ISSN":["0385-2407","1346-8138"],"issn-type":[{"value":"0385-2407","type":"print"},{"value":"1346-8138","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,12,10]]}}}