{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T11:17:13Z","timestamp":1780571833280,"version":"3.54.1"},"reference-count":0,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2015,1,27]],"date-time":"2015-01-27T00:00:00Z","timestamp":1422316800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Journal of Dermatology"],"published-print":{"date-parts":[[2015,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Because some users develop depigmentation after the use of melanogenesis\u2010inhibiting products containing the quasi\u2010drug ingredient Rhododenol, Japanese Dermatological Association (JDA) established a Special Committee on the Safety of Cosmetics Containing Rhododenol on July 17, 2013 and management guide for dermatologists has been updated on the website in order to delineate the diagnostic criteria for Rhododenol\u2010induced leukoderma and provides a broad guide for standard treatment based on current knowledge. This guide is produced on the basis of the guide (version 7) updated on June 20, 2014 in the website. Rhododenol\u2010induced leukoderma refers to depigmentation of varying severity that develops after the use of cosmetics containing Rhododenol, mainly at the site of use. In most cases, repigmentation of part or all the affected area is evident after discontinuation. Histopathologically cellular infiltration around the hair follicles and melanophages are present in most cases. The number of melanocytes in the lesion is declined but not totally absent in most cases. Rhododenol itself is a good substrate for tyrosinase, resulting in the formation of Rhododenol metabolites (e.g., Rhododenol quinone). Melanocytes are damaged by Rhododenol metabolites during the subsequent metabolic process. The continued use of cosmetics containing Rhododenol thus induces tyrosinase activity\u2010dependent cytotoxicity in melanocytes in the epidermis at application sites, resulting in decreasing the amount of melanin produced by melanocytes; the addition of some other factor to this process is believed to subsequently cause the decrease or disappearance of melanocytes themselves from the epidermis.<\/jats:p>","DOI":"10.1111\/1346-8138.12744","type":"journal-article","created":{"date-parts":[[2015,1,27]],"date-time":"2015-01-27T05:34:23Z","timestamp":1422336863000},"page":"113-128","source":"Crossref","is-referenced-by-count":56,"title":["Guide for medical professionals (i.e. dermatologists) for the management of Rhododenol\u2010induced leukoderma"],"prefix":"10.1111","volume":"42","author":[{"given":"Chikako","family":"Nishigori","sequence":"first","affiliation":[{"name":"Division of Dermatology Department of Internal Related Graduate School of Medicine Kobe University Kobe Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yumi","family":"Aoyama","sequence":"additional","affiliation":[{"name":"Dermatology Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Science Okayama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akiko","family":"Ito","sequence":"additional","affiliation":[{"name":"Department of Dermatology Niigata University Medical and Dental Hospital Niigata Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kayoko","family":"Suzuki","sequence":"additional","affiliation":[{"name":"Department of Dermatology Kariya Toyota General Hospital Kariya Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tamio","family":"Suzuki","sequence":"additional","affiliation":[{"name":"Department of Dermatology Yamagata University Faculty of Medicine Yamagata Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Atsushi","family":"Tanemura","sequence":"additional","affiliation":[{"name":"Department of Dermatology Course of Integrated Medicine Graduate School of Medicine Osaka University Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masaaki","family":"Ito","sequence":"additional","affiliation":[{"name":"Department of Dermatology Niigata University Graduate School of Medicine and Dental Science Niigata Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ichiro","family":"Katayama","sequence":"additional","affiliation":[{"name":"Department of Dermatology Course of Integrated Medicine Graduate School of Medicine Osaka University Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naoki","family":"Oiso","sequence":"additional","affiliation":[{"name":"Department of Dermatology Kinki University Faculty of Medicine Osaka\u2010Sayama"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuji","family":"Kagohashi","sequence":"additional","affiliation":[{"name":"Japanese Society for Dermatoallergology and Contact Dermatitis Tokyo"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shinichi","family":"Sugiura","sequence":"additional","affiliation":[{"name":"Department of Healthcare Administration Nagoya University Graduate School of Medicine Nagoya Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuyoshi","family":"Fukai","sequence":"additional","affiliation":[{"name":"Department of Dermatology Osaka City University Graduate School of Medicine Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoko","family":"Funasaka","sequence":"additional","affiliation":[{"name":"Department of Dermatology Nippon Medical School Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshiharu","family":"Yamashita","sequence":"additional","affiliation":[{"name":"Department of Dermatology Sapporo Medical University School of Medicine Sapporo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kayoko","family":"Matsunaga","sequence":"additional","affiliation":[{"name":"Department of Dermatology Fujita Health University School of Medicine Toyoake Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,1,27]]},"container-title":["The Journal of 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