{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T19:03:02Z","timestamp":1790622182339,"version":"4.1.0"},"reference-count":33,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2015,1,27]],"date-time":"2015-01-27T00:00:00Z","timestamp":1422316800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Journal of Dermatology"],"published-print":{"date-parts":[[2015,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Drug\u2010induced hypersensitivity syndrome\/drug reaction with eosinophilia and systemic symptoms (\n                    <jats:styled-content style=\"fixed-case\">DIHS<\/jats:styled-content>\n                    \/\n                    <jats:styled-content style=\"fixed-case\">DRESS<\/jats:styled-content>\n                    ) is a severe adverse drug reaction caused by specific drug. It is characterized by visceral organ involvement and reactivation of various human herpesviruses. Although sporadic reports have documented certain conditions that appear after the resolution of\n                    <jats:styled-content style=\"fixed-case\">DIHS<\/jats:styled-content>\n                    \/\n                    <jats:styled-content style=\"fixed-case\">DRESS<\/jats:styled-content>\n                    , little information is available on sequelae after resolution of\n                    <jats:styled-content style=\"fixed-case\">DIHS<\/jats:styled-content>\n                    \/\n                    <jats:styled-content style=\"fixed-case\">DRESS<\/jats:styled-content>\n                    in a large patient population. The\n                    <jats:styled-content style=\"fixed-case\">A<\/jats:styled-content>\n                    sian Research Committee on Severe Cutaneous Adverse Reactions, comprised of doctors from Japan and Taiwan, conducted a survey on sequelae and deterioration of the underlying disease in patients with\n                    <jats:styled-content style=\"fixed-case\">DIHS<\/jats:styled-content>\n                    \/\n                    <jats:styled-content style=\"fixed-case\">DRESS<\/jats:styled-content>\n                    . This was achieved by directly interviewing patients who had been followed\u2010up by experts or through a questionnaire mailed to patients. Questions were asked about new onset cardiovascular disease, collagen disease or autoimmune disease, gastrointestinal disease, renal disease, respiratory disease, neoplasms, and other diseases such as herpes zoster and diabetes mellitus, as well as deterioration of the underlying disease. A total of 145 patients were analyzed in this study. The following newly developed diseases after recovery from\n                    <jats:styled-content style=\"fixed-case\">DIHS<\/jats:styled-content>\n                    \/\n                    <jats:styled-content style=\"fixed-case\">DRESS<\/jats:styled-content>\n                    were observed:\n                    <jats:styled-content style=\"fixed-case\">G<\/jats:styled-content>\n                    raves' disease (\n                    <jats:italic>n\u00a0<\/jats:italic>\n                    =\u00a02),\n                    <jats:styled-content style=\"fixed-case\">H<\/jats:styled-content>\n                    ashimoto's disease (\n                    <jats:italic>n\u00a0<\/jats:italic>\n                    =\u00a03), painless thyroiditis (\n                    <jats:italic>n\u00a0<\/jats:italic>\n                    =\u00a02), fulminant type 1 diabetes mellitus (\n                    <jats:italic>n\u00a0<\/jats:italic>\n                    =\u00a05), and infectious diseases (\n                    <jats:italic>n\u00a0<\/jats:italic>\n                    =\u00a07). Several\n                    <jats:styled-content style=\"fixed-case\">DIHS<\/jats:styled-content>\n                    \/\n                    <jats:styled-content style=\"fixed-case\">DRESS<\/jats:styled-content>\n                    patients with pre\u2010existing renal dysfunction required lifelong hemodialysis.\n                    <jats:styled-content style=\"fixed-case\">DIHS<\/jats:styled-content>\n                    \/\n                    <jats:styled-content style=\"fixed-case\">DRESS<\/jats:styled-content>\n                    is a condition that increases the risk of new onset of disease. Long\u2010term observation of\n                    <jats:styled-content style=\"fixed-case\">DIHS<\/jats:styled-content>\n                    \/\n                    <jats:styled-content style=\"fixed-case\">DRESS<\/jats:styled-content>\n                    can provide an opportunity to investigate substantial diseases from onset to the full\u2010blown stage. Patients with\n                    <jats:styled-content style=\"fixed-case\">DIHS<\/jats:styled-content>\n                    \/\n                    <jats:styled-content style=\"fixed-case\">DRESS<\/jats:styled-content>\n                    require careful long\u2010term follow\u2010up.\n                  <\/jats:p>","DOI":"10.1111\/1346-8138.12770","type":"journal-article","created":{"date-parts":[[2015,1,27]],"date-time":"2015-01-27T00:32:12Z","timestamp":1422318732000},"page":"276-282","source":"Crossref","is-referenced-by-count":109,"title":["Sequelae in 145 patients with drug\u2010induced hypersensitivity syndrome\/drug reaction with eosinophilia and systemic symptoms: Survey conducted by the Asian Research Committee on Severe Cutaneous Adverse Reactions (\n                    <scp>ASCAR<\/scp>\n                    )"],"prefix":"10.1111","volume":"42","author":[{"given":"Yoko","family":"Kano","sequence":"first","affiliation":[{"name":"Department of Dermatology Kyorin University School of Medicine Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mikiko","family":"Tohyama","sequence":"additional","affiliation":[{"name":"Department of Dermatology Ehime University Graduate School of Medicine Ehime Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michiko","family":"Aihara","sequence":"additional","affiliation":[{"name":"Department of Environmental Immuno\u2010Dermatology Yokohama City University Graduate School of Medicine Yokohama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Setsuko","family":"Matsukura","sequence":"additional","affiliation":[{"name":"Department of Dermatology Yokohama City University Medical Center Yokohama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hideaki","family":"Watanabe","sequence":"additional","affiliation":[{"name":"Department of Dermatology Showa University School of Medicine Tokyo 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