{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T00:39:49Z","timestamp":1787013589805,"version":"build-2736575974"},"reference-count":14,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2015,1,9]],"date-time":"2015-01-09T00:00:00Z","timestamp":1420761600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Journal of Dermatology"],"published-print":{"date-parts":[[2015,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    A 72\u2010year\u2010old woman with a history of diffuse large B cell lymphoma and recent recurrence visited our department complaining of several painful edematous nodules with blisters on her face. She had iteratively developed cutaneous eruptions after every treatment with granulocyte colony\u2010stimulating factor (G\u2010\n                    <jats:styled-content style=\"fixed-case\">CSF<\/jats:styled-content>\n                    ) for neutropenia, and each time the eruption improved after the cessation of the G\u2010\n                    <jats:styled-content style=\"fixed-case\">CSF<\/jats:styled-content>\n                    treatment. The blisters became crusty and the skin lesions slightly improved, but on the 24th hospital day, the eruption formed painful erythematous nodules with erosion, and the patient also developed a high fever of up to 38\u00b0C. A biopsy specimen showed a dermal infiltrate of increased and enlarged plump histiocytes, some of which indicated karyomitosis with a small number of lymphocytes. No increase in the number of eosinophils or neutrophils was noted. These eruptions lasted for 15\u00a0days and disappeared with the recovery of the peripheral blood count and attendant cessation of G\u2010\n                    <jats:styled-content style=\"fixed-case\">CSF<\/jats:styled-content>\n                    . We diagnosed this case as G\u2010\n                    <jats:styled-content style=\"fixed-case\">CSF<\/jats:styled-content>\n                    \u2010induced granulomatous dermatitis with enlarged histiocytes. Several cases with maculopapular rash and dermal inflammatory infiltrate composed of interstitially arranged large histiocytes have been reported. However, to the best of our knowledge, this is the first case report of G\u2010\n                    <jats:styled-content style=\"fixed-case\">CSF<\/jats:styled-content>\n                    \u2010induced granulomatous dermatitis with enlarged histiocytes clinically manifesting as painful edematous nodules with a high fever, similar to Sweet's syndrome. We speculated that the infiltrating cells were not neutrophils but histiocytes, presumably because of agranulocytosis.\n                  <\/jats:p>","DOI":"10.1111\/1346-8138.12772","type":"journal-article","created":{"date-parts":[[2015,1,9]],"date-time":"2015-01-09T05:49:41Z","timestamp":1420782581000},"page":"414-417","source":"Crossref","is-referenced-by-count":8,"title":["Granulocyte colony\u2010stimulating factor\u2010induced granulomatous dermatitis with enlarged histiocytes clinically manifesting as painful edematous nodules with high fever similar to Sweet's syndrome"],"prefix":"10.1111","volume":"42","author":[{"given":"Saeko","family":"Ozaki","sequence":"first","affiliation":[{"name":"Department of Dermatology Nippon Medical School Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoko","family":"Funasaka","sequence":"additional","affiliation":[{"name":"Department of Dermatology Nippon Medical School Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masaya","family":"Takubo","sequence":"additional","affiliation":[{"name":"Department of Dermatology Nippon Medical School Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takemitsu","family":"Matayoshi","sequence":"additional","affiliation":[{"name":"Department of Dermatology Nippon Medical School Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takashi","family":"Ueno","sequence":"additional","affiliation":[{"name":"Department of Dermatology Nippon Medical School Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshio","family":"Asayama","sequence":"additional","affiliation":[{"name":"Department of Hematology Nippon Medical School Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hidehisa","family":"Saeki","sequence":"additional","affiliation":[{"name":"Department of Dermatology Nippon Medical School Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,1,9]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1159\/000090660"},{"key":"e_1_2_5_3_1","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1001\/archderm.1991.01680010059008","article-title":"Intravenous administration of recombinant human granulocyte\u2010macrophage colony\u2010stimulating factor causes a cutaneous eruption","volume":"127","author":"Horn TD","year":"1991","journal-title":"Arch Dermatol"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000372-199504000-00001"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0190-9622(96)90439-9"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0560.1998.tb01741.x"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0560.1998.tb01730.x"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.134.1.111"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-3083.2004.00872.x"},{"key":"e_1_2_5_10_1","first-page":"1579","article-title":"Phase 1 study of KRN 8601 (rhG\u2010CSF) in normal healthy volunteers: safety and pharmacokinetics in single intravenous infusion","volume":"8","author":"Azuma J","year":"1989","journal-title":"J Clin Ther Med"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.11150\/kansenshogakuzasshi1970.67.1094"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0190-9622(96)90080-8"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.141.7.834"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2014.01.874"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2011.40.3212"}],"container-title":["The Journal of Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2F1346-8138.12772","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1346-8138.12772","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,24]],"date-time":"2023-09-24T09:46:46Z","timestamp":1695548806000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/1346-8138.12772"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,1,9]]},"references-count":14,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2015,4]]}},"alternative-id":["10.1111\/1346-8138.12772"],"URL":"https:\/\/doi.org\/10.1111\/1346-8138.12772","archive":["Portico"],"relation":{},"ISSN":["0385-2407","1346-8138"],"issn-type":[{"value":"0385-2407","type":"print"},{"value":"1346-8138","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,1,9]]}}}