{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,25]],"date-time":"2026-10-25T09:13:06Z","timestamp":1792919586435,"version":"4.5.0"},"reference-count":36,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2015,1,13]],"date-time":"2015-01-13T00:00:00Z","timestamp":1421107200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Journal of Dermatology"],"published-print":{"date-parts":[[2015,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Localized scleroderma (<jats:styled-content style=\"fixed-case\">LS<\/jats:styled-content>c) primarily affects skin, whereas systemic sclerosis (<jats:styled-content style=\"fixed-case\">SS<\/jats:styled-content>c) affects skin and various internal organs. <jats:styled-content style=\"fixed-case\">LS<\/jats:styled-content>c and <jats:styled-content style=\"fixed-case\">SS<\/jats:styled-content>c are considered to be basically different diseases, and there is no transition between them. However, <jats:styled-content style=\"fixed-case\">LS<\/jats:styled-content>c and <jats:styled-content style=\"fixed-case\">SS<\/jats:styled-content>c have several common characteristics, including endothelial cell dysfunction, immune activation, and excess fibrosis of the skin, and there exist several <jats:styled-content style=\"fixed-case\">SS<\/jats:styled-content>c cases complicated with <jats:styled-content style=\"fixed-case\">LS<\/jats:styled-content>c during the course of <jats:styled-content style=\"fixed-case\">SS<\/jats:styled-content>c. Clinical and laboratory characteristics of <jats:styled-content style=\"fixed-case\">SS<\/jats:styled-content>c patients with <jats:styled-content style=\"fixed-case\">LS<\/jats:styled-content>c remain unclear. We investigated the clinical and laboratory features of 8 <jats:styled-content style=\"fixed-case\">SS<\/jats:styled-content>c patients with <jats:styled-content style=\"fixed-case\">LS<\/jats:styled-content>c among 220 <jats:styled-content style=\"fixed-case\">SS<\/jats:styled-content>c patients (3.6%). The types of <jats:styled-content style=\"fixed-case\">LS<\/jats:styled-content>c included plaque (5\/8), guttate (2\/8), and linear type (1\/8). All cases were diagnosed as having <jats:styled-content style=\"fixed-case\">SS<\/jats:styled-content>c within 5\u00a0years before or after the appearance of <jats:styled-content style=\"fixed-case\">LS<\/jats:styled-content>c. In three cases of <jats:styled-content style=\"fixed-case\">SS<\/jats:styled-content>c with <jats:styled-content style=\"fixed-case\">LS<\/jats:styled-content>c (37.5%), <jats:styled-content style=\"fixed-case\">LS<\/jats:styled-content>c skin lesions preceded clinical symptoms of <jats:styled-content style=\"fixed-case\">SS<\/jats:styled-content>c. Young age, negative antinuclear antibody, and positive anti\u2010<jats:styled-content style=\"fixed-case\">RNA<\/jats:styled-content> polymerase <jats:styled-content style=\"fixed-case\">III<\/jats:styled-content> antibody were significantly prevalent in <jats:styled-content style=\"fixed-case\">SS<\/jats:styled-content>c patients with <jats:styled-content style=\"fixed-case\">LS<\/jats:styled-content>c. The positivity of anticentromere antibody tended to be prevalent in <jats:styled-content style=\"fixed-case\">SS<\/jats:styled-content>c patients without <jats:styled-content style=\"fixed-case\">LS<\/jats:styled-content>c. No significant difference in the frequency of complications, such as interstitial lung disease, reflux esophagitis, and pulmonary artery hypertension, was observed. The awareness of these characteristic of <jats:styled-content style=\"fixed-case\">SS<\/jats:styled-content>c with <jats:styled-content style=\"fixed-case\">LS<\/jats:styled-content>c are essential to establish an early diagnosis and treatment.<\/jats:p>","DOI":"10.1111\/1346-8138.12775","type":"journal-article","created":{"date-parts":[[2015,1,13]],"date-time":"2015-01-13T20:45:54Z","timestamp":1421181954000},"page":"283-287","source":"Crossref","is-referenced-by-count":10,"title":["Clinical and laboratory features of systemic sclerosis complicated with localized scleroderma"],"prefix":"10.1111","volume":"42","author":[{"given":"Sayaka","family":"Toki","sequence":"first","affiliation":[{"name":"Department of Dermatology Gunma University Graduate School of Medicine Maebashi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sei\u2010ichiro","family":"Motegi","sequence":"additional","affiliation":[{"name":"Department of Dermatology Gunma University Graduate School of Medicine Maebashi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuya","family":"Yamada","sequence":"additional","affiliation":[{"name":"Department of Dermatology Gunma University Graduate School of Medicine Maebashi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akihiko","family":"Uchiyama","sequence":"additional","affiliation":[{"name":"Department of Dermatology Gunma University Graduate School of Medicine Maebashi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sahori","family":"Kanai","sequence":"additional","affiliation":[{"name":"Department of Dermatology Gunma University Graduate School of Medicine Maebashi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masayoshi","family":"Yamanaka","sequence":"additional","affiliation":[{"name":"Department of Dermatology Gunma University Graduate School of Medicine Maebashi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Osamu","family":"Ishikawa","sequence":"additional","affiliation":[{"name":"Department of Dermatology Gunma University Graduate School of Medicine Maebashi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,1,13]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1346-8138.2009.00758.x"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1346-8138.2009.00738.x"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2007.08392.x"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/1346-8138.12532"},{"key":"e_1_2_6_6_1","first-page":"171","article-title":"Localized scleroderma in adults and children. 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