{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T06:01:55Z","timestamp":1778565715946,"version":"3.51.4"},"reference-count":25,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2015,2,14]],"date-time":"2015-02-14T00:00:00Z","timestamp":1423872000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Journal of Dermatology"],"published-print":{"date-parts":[[2015,4]]},"abstract":"Abstract<\/jats:title>Infrared radiation A<\/jats:styled-content> (IRA<\/jats:styled-content>) is absorbed by melanin and generates heat. Therefore, the effect of IRA<\/jats:styled-content> could be well analyzed using skin, which contains melanin in the epidermis. Hairless mice harboring epidermal melanocytes that produce eumelanin, pheomelanin, or non\u2010melanin were generated by backcrossing K<\/jats:styled-content>14\u2010stem cell factor mice, recessive yellow mice, and then albino hairless mice. High\u2010dose IRA<\/jats:styled-content> was irradiated over 18\u00a0weeks after the establishment of photoaged mice by irradiation with ultraviolet B<\/jats:styled-content> (UVB<\/jats:styled-content>) three times a week for 14\u00a0weeks. Tumor formation was assessed every week. The formation of cyclobutane pyrimidine dimer and apoptotic cells by the irradiation of IRA<\/jats:styled-content> and UVB<\/jats:styled-content> was evaluated. Repetitive irradiation of IRA<\/jats:styled-content> did not promote tumor formation in all types of mice. Pre\u2010irradiation of IRA<\/jats:styled-content> to UVB, but not post\u2010irradiation, accelerated the elimination of cyclobutane pyrimidine dimers and enhanced apoptosis; these effects were most obvious in eumelanin\u2010producing mice. Real\u2010time polymerase chain reaction analysis showed downregulation of FLICE (cellular caspase 8)\u2010like inhibitory protein and B\u2010cell lymphoma\u2010extra large and upregulation of Bcl\u20102\u2010associated X protein by UVB<\/jats:styled-content>, but further enhancement of these molecules by pre\u2010irradiation of IRA<\/jats:styled-content> was not observed. These results indicate that IRA<\/jats:styled-content> does not confer the promotion of UVB<\/jats:styled-content>\u2010induced carcinogenesis in photoaged mice harboring epidermal melanocytes and that photochemical reaction between IRA<\/jats:styled-content> and melanin might be involved in the induction of apoptosis and the elimination of cyclobutane pyrimidine dimers by UVB<\/jats:styled-content>. The enhancement of apoptosis by pre\u2010irradiation of IRA<\/jats:styled-content> to UVB<\/jats:styled-content> might be induced by mechanisms other than the modification of the mRNA<\/jats:styled-content> expression of FLICE (cellular caspase 8)\u2010like inhibitory protein, B\u2010cell lymphoma\u2010extra large, and Bcl\u20102\u2010associated X.<\/jats:p>","DOI":"10.1111\/1346-8138.12790","type":"journal-article","created":{"date-parts":[[2015,2,14]],"date-time":"2015-02-14T07:03:16Z","timestamp":1423897396000},"page":"382-390","source":"Crossref","is-referenced-by-count":13,"title":["Effect of infrared radiation A<\/scp> on photoaged hairless mice harboring eumelanin and pheomelanin in the epidermis"],"prefix":"10.1111","volume":"42","author":[{"given":"Shizuka","family":"Okazaki","sequence":"first","affiliation":[{"name":"Department of Dermatology Nippon Medical School Tokyo 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