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Because there is a poor understanding of the complex mechanisms underlying the processes of hypertrophic scar formation, most therapeutic approaches remain clinically unsatisfactory. In this study, we found that mi<jats:styled-content style=\"fixed-case\">R<\/jats:styled-content>\u2010138 was downregulated and peroxisome proliferator\u2010activated receptor (<jats:styled-content style=\"fixed-case\">PPAR<\/jats:styled-content>\u03b2) was inversely upregulated in hypertrophic scar tissues compared to in paired normal skin tissues. Using a dual\u2010luciferase assay, we validated that mi<jats:styled-content style=\"fixed-case\">R<\/jats:styled-content>138 directly targets <jats:styled-content style=\"fixed-case\">PPAR<\/jats:styled-content>\u03b2 and regulates its expression at the transcriptional and translational levels. In gain\u2010and\u2010loss experiments, we found that mi<jats:styled-content style=\"fixed-case\">R<\/jats:styled-content>\u2010138\/<jats:styled-content style=\"fixed-case\">PPAR<\/jats:styled-content>\u03b2 signaling regulated human hypertrophic scar fibroblast proliferation and movement, and affected scarring\u2010related protein expression, which suggests that mi<jats:styled-content style=\"fixed-case\">R<\/jats:styled-content>\u2010138\/<jats:styled-content style=\"fixed-case\">PPAR<\/jats:styled-content>\u03b2 signaling is important for hypertrophic scarring. Thus, our study provides evidence to help determine whether mi<jats:styled-content style=\"fixed-case\">R<\/jats:styled-content>\u2010138\/<jats:styled-content style=\"fixed-case\">PPAR<\/jats:styled-content>\u03b2 signaling may be a potential target for hypertrophic scarring management.<\/jats:p>","DOI":"10.1111\/1346-8138.12792","type":"journal-article","created":{"date-parts":[[2015,3,6]],"date-time":"2015-03-06T07:04:53Z","timestamp":1425625493000},"page":"485-495","source":"Crossref","is-referenced-by-count":22,"title":["Mi<scp>R<\/scp>\u2010138\/peroxisome proliferator\u2010activated receptor \u03b2 signaling regulates human hypertrophic scar fibroblast proliferation and movement <i>in vitro<\/i>"],"prefix":"10.1111","volume":"42","author":[{"given":"Ying\u2010ying","family":"Xiao","sequence":"first","affiliation":[{"name":"Department of Plastic and Cosmetic Surgery XiangYa Hospital Central South University Changsha 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