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Omentin is a member of the adipokines, and has a protective effect against vascular inflammation and pathological remodeling leading to atherosclerosis as well as a vasodilatory effect. To assess the potential role of omentin in the development of <jats:styled-content style=\"fixed-case\">SS<\/jats:styled-content>c, we determined serum omentin levels by enzyme\u2010linked immunosorbent assay in 66 <jats:styled-content style=\"fixed-case\">SS<\/jats:styled-content>c and 21 control subjects and evaluated their clinical correlation. Serum omentin levels were significantly decreased in diffuse cutaneous <jats:styled-content style=\"fixed-case\">SS<\/jats:styled-content>c patients compared with limited cutaneous <jats:styled-content style=\"fixed-case\">SS<\/jats:styled-content>c patients, while comparable between total <jats:styled-content style=\"fixed-case\">SS<\/jats:styled-content>c patients and healthy controls. In diffuse cutaneous (dc)<jats:styled-content style=\"fixed-case\">SS<\/jats:styled-content>c, patients with a disease duration of 5\u00a0years or less had serum omentin levels significantly lower than those with a disease duration of more than 5\u00a0years. In total <jats:styled-content style=\"fixed-case\">SS<\/jats:styled-content>c, serum omentin levels were significantly higher in patients with elevated right ventricular systolic pressure than in the others, while serum omentin levels did not correlate with fibrotic and systemic inflammatory parameters. These results suggest that a loss of omentin\u2010dependent protection against vascular inflammation and remodeling may be related to pathological vascular events of early dc<jats:styled-content style=\"fixed-case\">SS<\/jats:styled-content>c. The elevation of serum omentin levels may serve as a marker of vascular involvement leading to pulmonary arterial hypertension in <jats:styled-content style=\"fixed-case\">SS<\/jats:styled-content>c, which is possibly due to the compensatory induction of omentin against the increased pulmonary vascular tone.<\/jats:p>","DOI":"10.1111\/1346-8138.12824","type":"journal-article","created":{"date-parts":[[2015,3,13]],"date-time":"2015-03-13T06:05:13Z","timestamp":1426226713000},"page":"461-466","source":"Crossref","is-referenced-by-count":16,"title":["Serum omentin levels: A possible contribution to vascular involvement in patients with systemic sclerosis"],"prefix":"10.1111","volume":"42","author":[{"given":"Shunsuke","family":"Miura","sequence":"first","affiliation":[{"name":"Department of Dermatology University of Tokyo Graduate School of Medicine Tokyo 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