{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T14:45:12Z","timestamp":1792507512310,"version":"4.5.0"},"reference-count":15,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2015,2,27]],"date-time":"2015-02-27T00:00:00Z","timestamp":1424995200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Journal of Dermatology"],"published-print":{"date-parts":[[2015,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Patients with systemic sclerosis (<jats:styled-content style=\"fixed-case\">SS<\/jats:styled-content>c) have an increased risk of malignancy compared with the general population. Recently, <jats:styled-content style=\"fixed-case\">SS<\/jats:styled-content>c patients with anti\u2010<jats:styled-content style=\"fixed-case\">RNA<\/jats:styled-content> polymerase <jats:styled-content style=\"fixed-case\">III<\/jats:styled-content> antibody have been reported to have an increased risk of malignancy as compared with those with other disease\u2010specific autoantibodies in US, European and Australian populations. Therefore, we studied the relationship between disease\u2010specific autoantibodies and malignancy in 261 Japanese <jats:styled-content style=\"fixed-case\">SS<\/jats:styled-content>c patients. The prevalence of malignancy was significantly higher in patients with anti\u2010<jats:styled-content style=\"fixed-case\">RNA<\/jats:styled-content> polymerase <jats:styled-content style=\"fixed-case\">III<\/jats:styled-content> antibody (7\/22, 31.8%) than in those with anti\u2010topoisomerase I antibody (2\/82, 2.4%) and in those with anticentromere antibody (8\/137, 5.8%). Importantly, among seven patients with anti\u2010<jats:styled-content style=\"fixed-case\">RNA<\/jats:styled-content> polymerase <jats:styled-content style=\"fixed-case\">III<\/jats:styled-content> antibody and malignancy, three patients (42.9%) developed malignancy from 6\u00a0months before to 12\u00a0months after <jats:styled-content style=\"fixed-case\">SS<\/jats:styled-content>c onset. Thus, malignancy complication in Japanese <jats:styled-content style=\"fixed-case\">SS<\/jats:styled-content>c patients with anti\u2010<jats:styled-content style=\"fixed-case\">RNA<\/jats:styled-content> polymerase <jats:styled-content style=\"fixed-case\">III<\/jats:styled-content> antibody is as high as that in other races, suggesting that <jats:styled-content style=\"fixed-case\">SS<\/jats:styled-content>c patients with anti\u2010<jats:styled-content style=\"fixed-case\">RNA<\/jats:styled-content> polymerase <jats:styled-content style=\"fixed-case\">III<\/jats:styled-content> antibody share the same pathological process among different ethnic groups.<\/jats:p>","DOI":"10.1111\/1346-8138.12827","type":"journal-article","created":{"date-parts":[[2015,2,27]],"date-time":"2015-02-27T07:38:56Z","timestamp":1425022736000},"page":"524-527","source":"Crossref","is-referenced-by-count":35,"title":["Association of anti\u2010<scp>RNA<\/scp> polymerase <scp>III<\/scp> antibody and malignancy in Japanese patients with systemic sclerosis"],"prefix":"10.1111","volume":"42","author":[{"given":"Ryosuke","family":"Saigusa","sequence":"first","affiliation":[{"name":"Department of Dermatology University of Tokyo Graduate School of Medicine Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshihide","family":"Asano","sequence":"additional","affiliation":[{"name":"Department of Dermatology University of Tokyo Graduate School of Medicine Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kouki","family":"Nakamura","sequence":"additional","affiliation":[{"name":"Department of Dermatology University of Tokyo Graduate School of Medicine Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shunsuke","family":"Miura","sequence":"additional","affiliation":[{"name":"Department of Dermatology University of Tokyo Graduate School of Medicine Tokyo 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