{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T14:33:02Z","timestamp":1792074782229,"version":"4.4.0"},"reference-count":14,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2015,3,13]],"date-time":"2015-03-13T00:00:00Z","timestamp":1426204800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Journal of Dermatology"],"published-print":{"date-parts":[[2015,5]]},"abstract":"Abstract<\/jats:title>Acne vulgaris is one of the most common skin diseases in adolescents. In the present study, we aimed to evaluate the effectiveness and safety of topical 5\u2010aminolevulinic acid (ALA<\/jats:styled-content>)\u2010mediated photodynamic therapy (PDT<\/jats:styled-content>) for the treatment of severe acne in Chinese adolescent patients. Twenty\u2010one Chinese adolescent patients aged 12\u201318\u00a0years with Pillsbury III<\/jats:styled-content>\u2013IV<\/jats:styled-content> severe facial acne were treated with three courses of ALA<\/jats:styled-content>\u2010PDT<\/jats:styled-content>. A 5% ALA<\/jats:styled-content> lotion was applied topically for 60\u00a0min followed by irradiation with light\u2010emitting diode light at 633\u00a0nm with a light intensity of 75\u201380\u00a0mW\/cm2<\/jats:sup> and a light dose of 90\u201396\u00a0J\/cm2<\/jats:sup>. Clinical assessment was conducted before and after each treatment, and at each follow\u2010up session. The total effective rates were 85.71%, 90.48%, and 95.23% after the three PDT<\/jats:styled-content> sessions, and at the 4\u2010 and 8\u2010week follow ups, respectively. ALA<\/jats:styled-content>\u2010PDT<\/jats:styled-content> is an effective treatment for severe adolescent acne vulgaris, and is associated with mild and reversible side\u2010effects.<\/jats:p>","DOI":"10.1111\/1346-8138.12836","type":"journal-article","created":{"date-parts":[[2015,3,13]],"date-time":"2015-03-13T13:49:16Z","timestamp":1426254556000},"page":"504-507","source":"Crossref","is-referenced-by-count":25,"title":["Prospective study of topical 5\u2010aminolevulinic acid photodynamic therapy for the treatment of severe adolescent acne in Chinese patients"],"prefix":"10.1111","volume":"42","author":[{"given":"Ying","family":"Ma","sequence":"first","affiliation":[{"name":"Department of Dermatology Huashan Hospital Fudan University Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ye","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Dermatology Huashan Hospital Fudan University Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qianqian","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Dermatology Huashan Hospital Fudan University Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Ren","sequence":"additional","affiliation":[{"name":"Department of Dermatology Huashan Hospital Fudan University Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leihong","family":"Xiang","sequence":"additional","affiliation":[{"name":"Department of Dermatology Huashan Hospital Fudan University Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,3,13]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.12149"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.1986.tb05757.x"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpag.2013.05.007"},{"key":"e_1_2_9_5_1","first-page":"1085","article-title":"New treatment strategy in acne vulgaris. Antibiotic prescription must be limited","volume":"109","author":"Mobacken H","year":"2012","journal-title":"L\u00e4kartidningen"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2009.09.057"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinthera.2004.11.012"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2013-0490B"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.sder.2011.08.001"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1590\/S0365-05962009000500002"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pdpdt.2013.03.008"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1747.2000.00046.x"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2004.06110.x"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pdpdt.2013.06.007"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-3083.2007.02503.x"}],"container-title":["The Journal of Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2F1346-8138.12836","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1346-8138.12836","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,23]],"date-time":"2023-09-23T19:28:25Z","timestamp":1695497305000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/1346-8138.12836"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,3,13]]},"references-count":14,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2015,5]]}},"alternative-id":["10.1111\/1346-8138.12836"],"URL":"https:\/\/doi.org\/10.1111\/1346-8138.12836","archive":["Portico"],"relation":{},"ISSN":["0385-2407","1346-8138"],"issn-type":[{"value":"0385-2407","type":"print"},{"value":"1346-8138","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,3,13]]}}}