{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T15:28:21Z","timestamp":1791300501095,"version":"4.1.0"},"reference-count":15,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2015,3,21]],"date-time":"2015-03-21T00:00:00Z","timestamp":1426896000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"the Ministry of Health, Labour, and Welfare of Japan"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Journal of Dermatology"],"published-print":{"date-parts":[[2015,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Heparanase is an endo\u2010\u03b2\u2010D\u2010glucuronidase cleaving heparan sulfate side\u2010chains of heparin sulfate proteoglycans, which is involved in wound healing, inflammation, neovascularization and tumor progression through the degradation and remodeling of the extracellular matrix and the release of sequestered pro\u2010angiogenic factors. Because heparanase\u2010mediated biological processes seem to be involved in the development of systemic sclerosis (<jats:styled-content style=\"fixed-case\">SS<\/jats:styled-content>c), we investigated the clinical correlation of serum heparanase levels in patients with this disease. Serum heparanase levels were significantly higher in <jats:styled-content style=\"fixed-case\">SS<\/jats:styled-content>c patients than in healthy individuals, while comparable between diffuse cutaneous <jats:styled-content style=\"fixed-case\">SS<\/jats:styled-content>c and limited cutaneous <jats:styled-content style=\"fixed-case\">SS<\/jats:styled-content>c subgroups. On the other hand, <jats:styled-content style=\"fixed-case\">SS<\/jats:styled-content>c patients with digital ulcers had serum heparanase levels significantly lower than those without. These results suggest that serum heparanase levels may be elevated in <jats:styled-content style=\"fixed-case\">SS<\/jats:styled-content>c patients reflecting the contribution of heparanase\u2010dependent biological processes to the development of <jats:styled-content style=\"fixed-case\">SS<\/jats:styled-content>c. <jats:styled-content style=\"fixed-case\">SS<\/jats:styled-content>c patients with high serum heparanase levels may be protected from the development of digital ulcers due to the increased release of sequestered pro\u2010angiogenic factors such as vascular endothelial growth factor. Therefore, serum heparanase levels may serve as a protective marker against digital ulcers in <jats:styled-content style=\"fixed-case\">SS<\/jats:styled-content>c patients.<\/jats:p>","DOI":"10.1111\/1346-8138.12842","type":"journal-article","created":{"date-parts":[[2015,3,24]],"date-time":"2015-03-24T17:23:56Z","timestamp":1427217836000},"page":"625-628","source":"Crossref","is-referenced-by-count":7,"title":["Serum heparanase levels: A protective marker against digital ulcers in patients with systemic sclerosis"],"prefix":"10.1111","volume":"42","author":[{"given":"Ching\u2010Ying","family":"Wu","sequence":"first","affiliation":[{"name":"Department of Dermatology University of Tokyo Graduate School of Medicine Tokyo Japan"},{"name":"Department of Dermatology Kaohsiung Medical University Kaohsiung Taiwan"},{"name":"College of Medicine Kaohsiung Medical University Kaohsiung Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshihide","family":"Asano","sequence":"additional","affiliation":[{"name":"Department of Dermatology University of Tokyo Graduate School of Medicine Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takashi","family":"Taniguchi","sequence":"additional","affiliation":[{"name":"Department of Dermatology University of Tokyo Graduate School of Medicine Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shinichi","family":"Sato","sequence":"additional","affiliation":[{"name":"Department of Dermatology University of Tokyo Graduate School of Medicine Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hsin\u2010Su","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Dermatology Kaohsiung Medical University Kaohsiung Taiwan"},{"name":"College of Medicine Kaohsiung Medical University Kaohsiung 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