{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T22:31:21Z","timestamp":1783031481929,"version":"3.54.6"},"reference-count":8,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2015,3,21]],"date-time":"2015-03-21T00:00:00Z","timestamp":1426896000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Journal of Dermatology"],"published-print":{"date-parts":[[2015,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Adrenergic urticaria (<jats:styled-content style=\"fixed-case\">AU<\/jats:styled-content>) is a rare type of stress\u2010induced physical urticaria characterized by widespread pruritic urticarial papules. Diagnosis can be made by i.d. injection of adrenaline or noradrenaline, which produces the characteristic rash. Although the lesions of <jats:styled-content style=\"fixed-case\">AU<\/jats:styled-content> typically respond to beta\u2010blockers such as propranolol, the therapeutic options for <jats:styled-content style=\"fixed-case\">AU<\/jats:styled-content> are limited. Here, we report a case of <jats:styled-content style=\"fixed-case\">AU<\/jats:styled-content> that was resistant to beta\u2010blockers and successfully treated with clotiazepam. The clinical picture of <jats:styled-content style=\"fixed-case\">AU<\/jats:styled-content> resembles that of cholinergic urticaria (<jats:styled-content style=\"fixed-case\">CU<\/jats:styled-content>), however, positive noradrenaline test and negative acetylcholine skin test were useful for the differential diagnosis of <jats:styled-content style=\"fixed-case\">AU<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">CU<\/jats:styled-content>. Although his symptoms were resistant to several therapeutic methods including olopatadine (H<jats:sub>1<\/jats:sub> antagonist), lafutidine (H<jats:sub>2<\/jats:sub> antagonist) and propranolol, the severity and frequency of his attacks and his subjective symptoms were reduced by oral clotiazepam, an anxiolytic benzodiazepine. Dermatologists should be aware that anxiolytic benzodiazepines may be a therapeutic option in <jats:styled-content style=\"fixed-case\">AU<\/jats:styled-content>.<\/jats:p>","DOI":"10.1111\/1346-8138.12855","type":"journal-article","created":{"date-parts":[[2015,3,24]],"date-time":"2015-03-24T17:23:32Z","timestamp":1427217812000},"page":"635-637","source":"Crossref","is-referenced-by-count":12,"title":["Refractory case of adrenergic urticaria successfully treated with clotiazepam"],"prefix":"10.1111","volume":"42","author":[{"given":"Yukari","family":"Kawakami","sequence":"first","affiliation":[{"name":"Division of Dermatology Department of Internal Related Kobe University Graduate School of Medicine Kobe Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mari","family":"Gokita","sequence":"additional","affiliation":[{"name":"Division of Dermatology Department of Internal Related Kobe University Graduate School of Medicine Kobe Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Atsushi","family":"Fukunaga","sequence":"additional","affiliation":[{"name":"Division of Dermatology Department of Internal Related Kobe University Graduate School of Medicine Kobe Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chikako","family":"Nishigori","sequence":"additional","affiliation":[{"name":"Division of Dermatology Department of Internal Related Kobe University Graduate School of Medicine Kobe Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,3,21]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(85)90905-5"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2013.10.062"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.2340\/00015555-0435"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11882-009-0038-x"},{"key":"e_1_2_5_6_1","first-page":"478","article-title":"Adrenergic urticaria: a first report from Thailand","volume":"72","author":"Vithayasai P","year":"1989","journal-title":"J Med Assoc Thai"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2007.08366.x"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.7205\/MILMED.173.2.217"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pnpbp.2005.08.007"}],"container-title":["The Journal of Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2F1346-8138.12855","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1346-8138.12855","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,23]],"date-time":"2023-09-23T21:30:43Z","timestamp":1695504643000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/1346-8138.12855"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,3,21]]},"references-count":8,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2015,6]]}},"alternative-id":["10.1111\/1346-8138.12855"],"URL":"https:\/\/doi.org\/10.1111\/1346-8138.12855","archive":["Portico"],"relation":{},"ISSN":["0385-2407","1346-8138"],"issn-type":[{"value":"0385-2407","type":"print"},{"value":"1346-8138","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,3,21]]}}}