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This study was designed to compare the safety and efficacy of bipolar<jats:styled-content style=\"fixed-case\">FRF<\/jats:styled-content>therapy as a treatment for atrophic acne scars and acne vulgaris. Twenty\u2010three Japanese patients with atrophic acne scars and mild to severe acne on both cheeks were treated with a bipolar<jats:styled-content style=\"fixed-case\">FRF<\/jats:styled-content>system (eMatrix; Syneron, Yokneam Illit, Israel). Five treatment sessions were carried out at 1\u2010month intervals, and the patients were followed up for 3\u00a0months after the final treatment. Assessments of scar severity and the number of acne lesions and 3\u2010D<jats:italic>in vivo<\/jats:italic>imaging analysis were performed. Evaluations of the treatment outcomes and their effects on the patients\u2019 quality of life (<jats:styled-content style=\"fixed-case\">QOL<\/jats:styled-content>) were also carried out. We demonstrated that the improvement in scar volume was marked in the patients with mild scars and was at least moderate in 23 (57.5%) of the treated areas. With regard to the number of acne lesions, the treated areas exhibited significantly fewer lesions compared with the baseline at each time point (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.05). The patients\u2019 assessments of the treatment outcomes and their<jats:styled-content style=\"fixed-case\">QOL<\/jats:styled-content>indicated that both had improved significantly by the end of the study. Furthermore, significant reductions in the patients\u2019 sebum levels, skin roughness and scar depth were observed. Bipolar<jats:styled-content style=\"fixed-case\">FRF<\/jats:styled-content>treatment significantly improved the atrophic acne scars and acne of Japanese patients and had minimal side\u2010effects.<\/jats:p>","DOI":"10.1111\/1346-8138.12864","type":"journal-article","created":{"date-parts":[[2015,4,9]],"date-time":"2015-04-09T06:41:24Z","timestamp":1428561684000},"page":"580-587","source":"Crossref","is-referenced-by-count":29,"title":["Clinical studies of the treatment of facial atrophic acne scars and acne with a bipolar fractional radiofrequency system"],"prefix":"10.1111","volume":"42","author":[{"given":"Chikako","family":"Kaminaka","sequence":"first","affiliation":[{"name":"Department of Dermatology Wakayama Medical University Wakayama Japan"},{"name":"Department of Cosmetic Dermatology and Photomedicine Wakayama Medical University Wakayama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mikiko","family":"Uede","sequence":"additional","affiliation":[{"name":"Department of Dermatology Wakayama Medical University Wakayama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroshi","family":"Matsunaka","sequence":"additional","affiliation":[{"name":"Department of Dermatology Wakayama Medical University Wakayama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fukumi","family":"Furukawa","sequence":"additional","affiliation":[{"name":"Department of Dermatology Wakayama Medical University Wakayama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuki","family":"Yamamoto","sequence":"additional","affiliation":[{"name":"Department of Dermatology Wakayama Medical University Wakayama Japan"},{"name":"Department of Cosmetic Dermatology and Photomedicine Wakayama Medical University Wakayama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,4,9]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2009.01.019"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2230.1994.tb01200.x"},{"issue":"15","key":"e_1_2_6_4_1","first-page":"17","article-title":"Intradermal focusing of near\u2010infrared optical pulses: a new approach for non\u2010ablative laser therapy","volume":"32","author":"Huzaira M","year":"2003","journal-title":"Lasers Surg Med"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2012.10870.x"},{"key":"e_1_2_6_6_1","first-page":"9","article-title":"Sublative rejuvenation: experience with a new fractional radiofrequency system for skin rejuvenation and repair","volume":"8","author":"Brightman L","year":"2009","journal-title":"J Drugs Dermatol"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00266-009-9361-9"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clindermatol.2007.05.005"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524-4725.2008.34399.x"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524-4725.2011.02110.x"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524-4725.2011.02267.x"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.3109\/14764172.2012.687824"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524-4725.2012.02402.x"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/dsu.12372"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/1346-8138.12471"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.DSS.0000452625.01889.c3"},{"key":"e_1_2_6_17_1","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1111\/j.1346-8138.2007.00403.x-i1","article-title":"Acne Study Group. Establishment of grading criteria for acne severity","volume":"35","author":"Hayashi N","year":"2008","journal-title":"J Dermatol"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524-4725.2006.32354.x"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2010.03.006"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1346-8138.2002.tb00205.x"},{"key":"e_1_2_6_21_1","first-page":"1","article-title":"A Histological study on the treatment of acne scars with fractional radiofrequency: preliminary findings","volume":"5","author":"Omi T","year":"2014","journal-title":"J Clin Exp Dermatol Res"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/1346-8138.12483"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1067\/mjd.2003.618"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-4632.2011.05029.x"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1346-8138.2004.tb00639.x"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/dsu.12103"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2009.08.051"},{"key":"e_1_2_6_28_1","first-page":"259","article-title":"Skin rejuvenation and wrinkle reduction using a fractional radiofrequency system","volume":"8","author":"Hruza G","year":"2009","journal-title":"J Drugs Dermatol"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524-4725.2012.02547.x"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2010.06.045"}],"container-title":["The Journal of Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2F1346-8138.12864","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1346-8138.12864","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,8]],"date-time":"2024-06-08T08:41:36Z","timestamp":1717836096000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/1346-8138.12864"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,4,9]]},"references-count":29,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2015,6]]}},"alternative-id":["10.1111\/1346-8138.12864"],"URL":"https:\/\/doi.org\/10.1111\/1346-8138.12864","archive":["Portico"],"relation":{},"ISSN":["0385-2407","1346-8138"],"issn-type":[{"value":"0385-2407","type":"print"},{"value":"1346-8138","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,4,9]]}}}