{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,9]],"date-time":"2025-12-09T15:38:39Z","timestamp":1765294719430},"reference-count":21,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2015,4,28]],"date-time":"2015-04-28T00:00:00Z","timestamp":1430179200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Journal of Dermatology"],"published-print":{"date-parts":[[2015,8]]},"abstract":"Abstract<\/jats:title>Varicella is a highly contagious infection caused by varicella zoster virus. Sometimes it is difficult to differentiate between other viral infections such as Kaposi's varicelliform eruption (KVE<\/jats:styled-content>) and disseminated herpes zoster (HZ<\/jats:styled-content>). The large unstained cells (LUC<\/jats:styled-content>) value is a differential count parameter reported by routing hematology analysis. LUC<\/jats:styled-content> have been studied previously, but never been reported in the context of varicella or in dermatological published work. The aim of this study was to compare the LUC<\/jats:styled-content> values in varicella patients with that in KVE<\/jats:styled-content> and disseminated HZ<\/jats:styled-content> patients. Sixty\u2010nine varicella patients, 30 KVE<\/jats:styled-content> patients and 11 disseminated HZ<\/jats:styled-content> patients were included in this retrospective study. All data were analyzed using SPSS<\/jats:styled-content> version 17.0 or GraphPad Prism version 5.0. The mean percentage of LUC<\/jats:styled-content> (%LUC<\/jats:styled-content>) in varicella patients was higher than the upper limit of normal reference range and it was increased compared to %LUC<\/jats:styled-content> of both KVE<\/jats:styled-content> (P<\/jats:italic>\u00a0<\u00a00.0001) and disseminated HZ<\/jats:styled-content> (P<\/jats:italic>\u00a0=\u00a00.0051) patients. %LUC<\/jats:styled-content> of varicella patients significantly decreased with clinical improvements (P<\/jats:italic>\u00a0=\u00a00.0017). %LUC<\/jats:styled-content> was significantly increased in varicella patients and corresponded with clinical improvements. Patients with %LUC<\/jats:styled-content> of 3.55 or more favor the diagnosis of varicella over both KVE<\/jats:styled-content> and disseminated HZ<\/jats:styled-content> with 71.01% sensitivity and 84.44% specificity. We suggest that %LUC<\/jats:styled-content> can assist in making a precise diagnosis of varicella in confusing cases.<\/jats:p>","DOI":"10.1111\/1346-8138.12902","type":"journal-article","created":{"date-parts":[[2015,4,28]],"date-time":"2015-04-28T06:26:33Z","timestamp":1430202393000},"page":"795-799","source":"Crossref","is-referenced-by-count":16,"title":["Increased large unstained cells value in varicella patients: A valuable parameter to aid rapid diagnosis of varicella infection"],"prefix":"10.1111","volume":"42","author":[{"given":"Dongyun","family":"Shin","sequence":"first","affiliation":[{"name":"Department of Dermatology Severance Hospital Cutaneous Biology Research Institute Yonsei University College of Medicine Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Min Seok","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Dermatology Severance Hospital Cutaneous Biology Research Institute Yonsei University College of Medicine Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Do Young","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Dermatology Severance Hospital Cutaneous Biology Research Institute Yonsei University College of Medicine Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Min\u2010Geol","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Dermatology Severance Hospital Cutaneous Biology Research Institute Yonsei University College of Medicine Seoul Korea"},{"name":"Brain Korea 21 Plus Project for Medical Science Yonsei University College of Medicine Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dae Suk","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Dermatology Severance Hospital Cutaneous Biology Research Institute Yonsei University College of Medicine Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,4,28]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(06)69561-5"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1994.03510290057037"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1159\/000355184"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1186\/1755-7682-5-2"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11239-012-0718-6"},{"key":"e_1_2_6_7_1","doi-asserted-by":"crossref","first-page":"1100","DOI":"10.1093\/clinchem\/45.7.1100","article-title":"LUC, what is that? 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