{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,9,25]],"date-time":"2023-09-25T11:09:47Z","timestamp":1695640187774},"reference-count":14,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2015,5,11]],"date-time":"2015-05-11T00:00:00Z","timestamp":1431302400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"by Health and Labor Sciences Research Grants from the Ministry of Health, Labor and Welfare of Japan","award":["H26-nanchi(nan)-ippan-081"],"award-info":[{"award-number":["H26-nanchi(nan)-ippan-081"]}]},{"name":"JSPS KAKENHI Grant","award":["24790534"],"award-info":[{"award-number":["24790534"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Journal of Dermatology"],"published-print":{"date-parts":[[2015,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Several interleukin (<jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>)\u201010 producing B\u2010cell subsets have been identified recently. However, few studies have examined the role of them in toxic epidermal necrolysis (<jats:styled-content style=\"fixed-case\">TEN<\/jats:styled-content>). We describe a 41\u2010year\u2010old woman with <jats:styled-content style=\"fixed-case\">TEN<\/jats:styled-content> who had B\u2010cell lymphoma and a history of treatments including B\u2010cell depletion therapy. Her re\u2010epithelization was still ongoing after 7\u00a0months, despite treatments. To investigate her immune system, we compared cytokine and chemokine production from B cells and non\u2010B cells isolated from the patient and another non\u2010lymphoma <jats:styled-content style=\"fixed-case\">TEN<\/jats:styled-content> patient. <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u201010 production from B cells decreased in the patient compared with the control <jats:styled-content style=\"fixed-case\">TEN<\/jats:styled-content>\u2010only patient. Cytokine and chemokine levels from non\u2010B cells involved in inflammation were elevated in the patient compared with the control patient. In conclusion, this study demonstrates that <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u201010 from B cells as well as regulatory T cells is critical in the pathogenesis of <jats:styled-content style=\"fixed-case\">TEN<\/jats:styled-content>, and that B\u2010cell dysfunction based on B\u2010cell lymphoma and B\u2010cell depletion therapy may be involved in the intractability of <jats:styled-content style=\"fixed-case\">TEN<\/jats:styled-content>.<\/jats:p>","DOI":"10.1111\/1346-8138.12909","type":"journal-article","created":{"date-parts":[[2015,5,11]],"date-time":"2015-05-11T06:45:33Z","timestamp":1431326733000},"page":"804-808","source":"Crossref","is-referenced-by-count":2,"title":["Reduction of interleukin\u201010 production by <scp>B<\/scp> cells in intractable toxic epidermal necrolysis"],"prefix":"10.1111","volume":"42","author":[{"given":"Amiko","family":"Hakuta","sequence":"first","affiliation":[{"name":"Department of Environmental Immuno\u2010Dermatology Yokohama City University Graduate School of Medicine Yokohama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroyuki","family":"Fujita","sequence":"additional","affiliation":[{"name":"Department of Environmental Immuno\u2010Dermatology Yokohama City University Graduate School of Medicine Yokohama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miwa","family":"Kanaoka","sequence":"additional","affiliation":[{"name":"Department of Environmental Immuno\u2010Dermatology Yokohama City University Graduate School of Medicine Yokohama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Midori","family":"Watanabe","sequence":"additional","affiliation":[{"name":"Department of Environmental Immuno\u2010Dermatology Yokohama City University Graduate School of Medicine Yokohama 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