{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T10:39:58Z","timestamp":1790073598868,"version":"4.0.1"},"reference-count":38,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2015,5,18]],"date-time":"2015-05-18T00:00:00Z","timestamp":1431907200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Journal of Dermatology"],"published-print":{"date-parts":[[2015,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Early differentiation of erysipelas from deep vein thrombosis (<jats:styled-content style=\"fixed-case\">DVT<\/jats:styled-content>) based solely on clinical signs and symptoms is challenging. There is a lack of data regarding the usefulness of the inflammatory biomarkers procalcitonin (<jats:styled-content style=\"fixed-case\">PCT<\/jats:styled-content>), C\u2010reactive protein (<jats:styled-content style=\"fixed-case\">CRP<\/jats:styled-content>) and white blood cell (<jats:styled-content style=\"fixed-case\">WBC<\/jats:styled-content>) count in the diagnosis of localized cutaneous infections. Herein, we investigated the diagnostic value of inflammatory markers in a prospective at\u2010risk patient population. This is an observational quality control study including consecutive patients presenting with a final diagnosis of either erysipelas or <jats:styled-content style=\"fixed-case\">DVT<\/jats:styled-content>. The association of <jats:styled-content style=\"fixed-case\">PCT<\/jats:styled-content> (\u03bcg\/L) and <jats:styled-content style=\"fixed-case\">CRP<\/jats:styled-content> (mg\/L) levels and <jats:styled-content style=\"fixed-case\">WBC<\/jats:styled-content> counts (g\/L) with the primary outcome was assessed using logistic regression models with area under the receiver\u2013operator curve. Forty\u2010eight patients (erysipelas, <jats:italic>n<\/jats:italic>\u00a0=\u00a031; <jats:styled-content style=\"fixed-case\">DVT<\/jats:styled-content>,<jats:italic> n<\/jats:italic>\u00a0=\u00a017) were included. Compared with patients with <jats:styled-content style=\"fixed-case\">DVT<\/jats:styled-content>, those with erysipelas had significantly higher PCT concentrations. No significant differences in <jats:styled-content style=\"fixed-case\">CRP<\/jats:styled-content> concentrations and <jats:styled-content style=\"fixed-case\">WBC<\/jats:styled-content> counts were found between the two groups. At a <jats:styled-content style=\"fixed-case\">PCT<\/jats:styled-content> threshold of 0.1\u00a0\u03bcg\/L or more, specificity and positive predictive values (PPV) for erysipelas were 82.4% and 85.7%, respectively, and increased to 100% and 100% at a threshold of more than 0.25\u00a0\u03bcg\/L. Levels of <jats:styled-content style=\"fixed-case\">PCT<\/jats:styled-content> also correlated with the severity of erysipelas, with a stepwise increase according to systemic inflammatory response syndrome criteria. We found a high discriminatory value of <jats:styled-content style=\"fixed-case\">PCT<\/jats:styled-content> for differentiation between erysipelas and <jats:styled-content style=\"fixed-case\">DVT<\/jats:styled-content>, in contrast to other commonly used inflammatory biomarkers. Whether the use of <jats:styled-content style=\"fixed-case\">PCT<\/jats:styled-content> levels for early differentiation of erysipelas from <jats:styled-content style=\"fixed-case\">DVT<\/jats:styled-content> reduces unnecessary antibiotic exposure needs to be assessed in an interventional trial.<\/jats:p>","DOI":"10.1111\/1346-8138.12922","type":"journal-article","created":{"date-parts":[[2015,5,18]],"date-time":"2015-05-18T06:01:21Z","timestamp":1431928881000},"page":"778-785","source":"Crossref","is-referenced-by-count":29,"title":["Use of procalcitonin, C\u2010reactive protein and white blood cell count to distinguish between lower limb erysipelas and deep vein thrombosis in the emergency department: A prospective observational study"],"prefix":"10.1111","volume":"42","author":[{"given":"Anna C.","family":"Rast","sequence":"first","affiliation":[{"name":"University Department of Internal Medicine Kantonsspital Aarau Aarau Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Demian","family":"Knobel","sequence":"additional","affiliation":[{"name":"University Department of Internal Medicine Kantonsspital Aarau Aarau Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lukas","family":"Faessler","sequence":"additional","affiliation":[{"name":"University Department of Internal Medicine Kantonsspital Aarau Aarau Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander","family":"Kutz","sequence":"additional","affiliation":[{"name":"University Department of Internal Medicine Kantonsspital Aarau Aarau Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan","family":"Felder","sequence":"additional","affiliation":[{"name":"University Department of Internal Medicine Kantonsspital Aarau Aarau Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Svenja","family":"Laukemann","sequence":"additional","affiliation":[{"name":"University Department of Internal Medicine Kantonsspital Aarau Aarau Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deborah","family":"Steiner","sequence":"additional","affiliation":[{"name":"University Department of Internal Medicine Kantonsspital Aarau Aarau Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sebastian","family":"Haubitz","sequence":"additional","affiliation":[{"name":"University Clinic of Infectious Diseases University Hospital Bern Bern Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christoph A.","family":"Fux","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases University Department of Internal Medicine Kantonsspital Aarau Aarau 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