{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,12]],"date-time":"2026-06-12T16:01:56Z","timestamp":1781280116257,"version":"3.54.1"},"reference-count":25,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2015,5,18]],"date-time":"2015-05-18T00:00:00Z","timestamp":1431907200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"National Cancer Center Research and Development Fund","award":["26-A-4"],"award-info":[{"award-number":["26-A-4"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Journal of Dermatology"],"published-print":{"date-parts":[[2015,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Subungual melanomas (<jats:styled-content style=\"fixed-case\">SUM<\/jats:styled-content>) are rare, and amputation is often required. Non\u2010amputative wide local excision (<jats:styled-content style=\"fixed-case\">WLE<\/jats:styled-content>) of the nail unit with the periosteum of the distal phalanx, followed by skin graft, has been accepted for <jats:italic>in\u00a0situ<\/jats:italic> or <jats:styled-content style=\"fixed-case\">SUM<\/jats:styled-content> of 0.5\u00a0mm or less thickness. However, previous reports have included a limited number of cases, and not all more than 0.5\u2010mm thick <jats:styled-content style=\"fixed-case\">SUM<\/jats:styled-content> exhibit invasion or attachment to the distal phalanx. The aim of the present study was to investigate the local recurrence and prognosis for <jats:italic>in\u00a0situ<\/jats:italic>, minimally invasive and invasive <jats:styled-content style=\"fixed-case\">SUM<\/jats:styled-content> that were treated using <jats:styled-content style=\"fixed-case\">WLE<\/jats:styled-content>. We retrospectively reviewed 50 patients with <jats:italic>in\u00a0situ<\/jats:italic> (<jats:italic>n<\/jats:italic>\u00a0=\u00a048) or minimally invasive <jats:styled-content style=\"fixed-case\">SUM<\/jats:styled-content> (<jats:italic>n<\/jats:italic>\u00a0=\u00a02) (<jats:italic>in\u00a0situ<\/jats:italic> or minimally invasive group) and 12 patients with more than 0.5\u2010mm thick invasive <jats:styled-content style=\"fixed-case\">SUM<\/jats:styled-content> (invasive group) who were treated using <jats:styled-content style=\"fixed-case\">WLE<\/jats:styled-content>. All patients survived the follow\u2010up period (24\u2013207\u00a0months), although four patients with <jats:italic>in\u00a0situ <\/jats:italic><jats:styled-content style=\"fixed-case\">SUM<\/jats:styled-content> experienced local recurrence at the lateral margin and re\u2010excision was required. In the invasive group, no patients experienced local recurrence, although one patient (8.3%) developed nodal metastasis at 86\u00a0months and regional lymph node dissection was required. <jats:styled-content style=\"fixed-case\">WLE<\/jats:styled-content> may provide acceptable local control for <jats:italic>in\u00a0situ<\/jats:italic> and intermediate thickness <jats:styled-content style=\"fixed-case\">SUM<\/jats:styled-content>, without compromising the vital prognosis. However, a larger randomized prospective study with long\u2010term follow up is required to evaluate adequately the risks associated with a non\u2010amputative <jats:styled-content style=\"fixed-case\">WLE<\/jats:styled-content> for <jats:italic>in\u00a0situ<\/jats:italic> and invasive <jats:styled-content style=\"fixed-case\">SUM<\/jats:styled-content>.<\/jats:p>","DOI":"10.1111\/1346-8138.12923","type":"journal-article","created":{"date-parts":[[2015,5,18]],"date-time":"2015-05-18T06:38:58Z","timestamp":1431931138000},"page":"861-866","source":"Crossref","is-referenced-by-count":44,"title":["Effects of non\u2010amputative wide local excision on the local control and prognosis of <i>in\u00a0situ<\/i> and invasive subungual melanoma"],"prefix":"10.1111","volume":"42","author":[{"given":"Yasuhiro","family":"Nakamura","sequence":"first","affiliation":[{"name":"Department of Skin Oncology\/Dermatology Saitama Medical University International Medical Center Saitama 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