{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T01:06:13Z","timestamp":1785546373961,"version":"3.56.0"},"reference-count":38,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2015,5,18]],"date-time":"2015-05-18T00:00:00Z","timestamp":1431907200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Journal of Dermatology"],"published-print":{"date-parts":[[2015,8]]},"abstract":"Abstract<\/jats:title>Stevens\u2013J<\/jats:styled-content>ohnson syndrome (SJS<\/jats:styled-content>) and toxic epidermal necrolysis (TEN<\/jats:styled-content>) are rare and life\u2010threatening cutaneous adverse drug reactions. While there is no established therapy for SJS<\/jats:styled-content>\/TEN<\/jats:styled-content>, systemic corticosteroids, plasma exchange and i.v. immunoglobulin (IVIG<\/jats:styled-content>) have been used as treatment. The efficacy of IVIG<\/jats:styled-content> is still controversial because total doses of IVIG<\/jats:styled-content> used vary greatly from one study to another. The aim of this study was to evaluate the efficacy of IVIG<\/jats:styled-content>, administrated for 5\u00a0days consecutively, in an open\u2010label, multicenter, single\u2010arm study in patients with SJS<\/jats:styled-content> or TEN<\/jats:styled-content>. IVIG<\/jats:styled-content> (400\u00a0mg\/kg per day) administrated for 5\u00a0days consecutively was performed as an additional therapy to systemic steroids in adult patients with SJS<\/jats:styled-content> or TEN<\/jats:styled-content>. Efficacy on day 7 of IVIG<\/jats:styled-content> was evaluated. Parameters to assess clinical outcome were enanthema including ophthalmic and oral lesions, cutaneous lesions and general condition. These parameters were scored and recorded before and after IVIG<\/jats:styled-content>. We enrolled five patients with SJS<\/jats:styled-content> and three patients with TEN<\/jats:styled-content> who did not respond sufficiently to systemic steroids before IVIG<\/jats:styled-content> administration. All of the patients survived and the efficacy on day 7 of the IVIG<\/jats:styled-content> was 87.5% (7\/8 patients). Prompt amelioration was observed in skin lesions and enanthema in the patients in whom IVIG<\/jats:styled-content> therapy was effective. Serious side\u2010effects from the use of IVIG<\/jats:styled-content> were not observed. IVIG<\/jats:styled-content> (400\u00a0mg\/kg per day) administrated for 5\u00a0days consecutively seems to be effective in patients with SJS<\/jats:styled-content> or TEN<\/jats:styled-content>. IVIG<\/jats:styled-content> administrated together with steroids should be considered as a treatment modality for patients with refractory SJS<\/jats:styled-content>\/TEN<\/jats:styled-content>. Further studies are needed to define the therapeutic efficacy of IVIG<\/jats:styled-content>.<\/jats:p>","DOI":"10.1111\/1346-8138.12925","type":"journal-article","created":{"date-parts":[[2015,5,18]],"date-time":"2015-05-18T06:39:20Z","timestamp":1431931160000},"page":"768-777","source":"Crossref","is-referenced-by-count":51,"title":["Efficacy of additional i.v. immunoglobulin to steroid therapy in S<\/scp>tevens\u2013J<\/scp>ohnson syndrome and toxic epidermal necrolysis"],"prefix":"10.1111","volume":"42","author":[{"given":"Michiko","family":"Aihara","sequence":"first","affiliation":[{"name":"Department of Dermatology Yokohama City University School of Medicine Yokohama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoko","family":"Kano","sequence":"additional","affiliation":[{"name":"Department of Dermatology Kyorin University School of Medicine Tokyo 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