{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T20:39:24Z","timestamp":1791319164000,"version":"4.3.1"},"reference-count":6,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2015,5,11]],"date-time":"2015-05-11T00:00:00Z","timestamp":1431302400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Journal of Dermatology"],"published-print":{"date-parts":[[2015,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Hypohidrosis and anhidrosis are congenital or acquired conditions which are characterized by inadequate sweating. Acquired idiopathic generalized hypohidrosis\/anhidrosis (<jats:styled-content style=\"fixed-case\">AIGA<\/jats:styled-content>) includes idiopathic pure sudomotor failure (<jats:styled-content style=\"fixed-case\">IPSF<\/jats:styled-content>), which has the following distinct features: sudden onset in youth, increased serum immunoglobulin <jats:styled-content style=\"fixed-case\">E<\/jats:styled-content> and responds favorably to systemic corticosteroid. No clinical markers reflecting the disease severity or activity have been established. Here, we report a case of <jats:styled-content style=\"fixed-case\">AIGA<\/jats:styled-content> in a <jats:styled-content style=\"fixed-case\">J<\/jats:styled-content>apanese patient successfully treated with repeated methylprednisolone pulse therapy. In this case, serum carcinoembryonic antigen (<jats:styled-content style=\"fixed-case\">CEA<\/jats:styled-content>) levels increased up to 19.8\u00a0ng\/mL along with aberrant <jats:styled-content style=\"fixed-case\">CEA<\/jats:styled-content> immunoreactivity of eccrine sweat glands. Interestingly, the serum <jats:styled-content style=\"fixed-case\">CEA<\/jats:styled-content> level normalized as sweating improved with repeated methylprednisolone pulse therapy. Therefore, serum <jats:styled-content style=\"fixed-case\">CEA<\/jats:styled-content> level may serve as a useful clinical marker of hypohidrosis or anhidrosis.<\/jats:p>","DOI":"10.1111\/1346-8138.12926","type":"journal-article","created":{"date-parts":[[2015,5,11]],"date-time":"2015-05-11T06:23:18Z","timestamp":1431325398000},"page":"900-902","source":"Crossref","is-referenced-by-count":17,"title":["Correlation of disease activity and serum level of carcinoembryonic antigen in acquired idiopathic generalized anhidrosis: A case report"],"prefix":"10.1111","volume":"42","author":[{"given":"Masaru","family":"Honma","sequence":"first","affiliation":[{"name":"Department of Dermatology Asahikawa Medical University Asahikawa Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shin","family":"Iinuma","sequence":"additional","affiliation":[{"name":"Department of Dermatology Asahikawa Medical University Asahikawa Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyoko","family":"Kanno","sequence":"additional","affiliation":[{"name":"Department of Dermatology Asahikawa Medical University Asahikawa Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shigetsuna","family":"Komatsu","sequence":"additional","affiliation":[{"name":"Department of Dermatology Asahikawa Medical University Asahikawa Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masako","family":"Minami\u2010Hori","sequence":"additional","affiliation":[{"name":"Department of Dermatology Asahikawa Medical University Asahikawa Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akemi","family":"Ishida\u2010Yamamoto","sequence":"additional","affiliation":[{"name":"Department of Dermatology Asahikawa Medical University Asahikawa Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,5,11]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1212\/01.WNL.0000142036.54112.57"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2012.11112.x"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/1523-1747.ep12327258"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ceb.2006.08.008"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/mi.2008.50"},{"key":"e_1_2_5_7_1","first-page":"2749","article-title":"Multicentre tumour marker reference range study","volume":"19","author":"Wilson AP","year":"1999","journal-title":"Anticancer Res"}],"container-title":["The Journal of Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2F1346-8138.12926","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1346-8138.12926","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,24]],"date-time":"2023-09-24T06:27:01Z","timestamp":1695536821000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/1346-8138.12926"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,5,11]]},"references-count":6,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2015,9]]}},"alternative-id":["10.1111\/1346-8138.12926"],"URL":"https:\/\/doi.org\/10.1111\/1346-8138.12926","archive":["Portico"],"relation":{},"ISSN":["0385-2407","1346-8138"],"issn-type":[{"value":"0385-2407","type":"print"},{"value":"1346-8138","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,5,11]]}}}