{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,20]],"date-time":"2026-03-20T16:30:21Z","timestamp":1774024221993,"version":"3.50.1"},"reference-count":15,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2015,5,25]],"date-time":"2015-05-25T00:00:00Z","timestamp":1432512000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Journal of Dermatology"],"published-print":{"date-parts":[[2015,9]]},"abstract":"Abstract<\/jats:title>Xeroderma pigmentosum (XP<\/jats:styled-content>) is an autosomal recessive genetic disorder characterized by extraordinary sensitivity to sunlight, resulting in cutaneous malignant tumors. Among XP<\/jats:styled-content>, XP<\/jats:styled-content>\u2010F presents relatively uniquely in Japanese. To clarify the characteristics of this group, we describe a case of XP<\/jats:styled-content>\u2010F and review Japanese cases previously reported. A 50\u2010year\u2010old Japanese woman was referred to us with multiple, variously sized, light\u2010 or dark\u2010brown macules on the face and sunlight\u2010exposed extremities. She had experienced bulla formation with approximately 10\u00a0min of sunlight exposure during her elementary school years. Her parents had been first cousins, and her mother and sister had photosensitivity. She showed no neurological or developmental abnormalities. Ultraviolet (UV<\/jats:styled-content>) irradiation testing revealed normal levels for minimal erythema dose with UV\u2010A<\/jats:styled-content> and UV\u2010B<\/jats:styled-content>. Sensitivity to UV\u2010C<\/jats:styled-content> and DNA<\/jats:styled-content> repair ability in the patient's fibroblasts were indicated between that in normal individuals and that in an XP\u2010A<\/jats:styled-content> patient. Complementation assay revealed that transfection of the XPF<\/jats:styled-content><\/jats:italic> gene led most efficient DNA<\/jats:styled-content> repair compared with the other XP<\/jats:styled-content><\/jats:italic> genes. Therefore, the patient was diagnosed with XP\u2010F<\/jats:styled-content>. Twenty\u2010three cases of Japanese patients (six males, 17 females) with XP\u2010F<\/jats:styled-content> have been reported, including the present case. Our review suggested a relatively high prevalence of 50% (11\/22) for cutaneous malignant tumors. A significant difference was evident in the mean age at first medical consultation between patients with cutaneous malignant tumors (53.6\u00a0years) and patients without such tumors (30.8\u00a0years). This suggests that cutaneous malignant tumors could occur in the age range of 30\u201350\u00a0years in XP\u2010F<\/jats:styled-content> patients.<\/jats:p>","DOI":"10.1111\/1346-8138.12942","type":"journal-article","created":{"date-parts":[[2015,5,25]],"date-time":"2015-05-25T20:03:45Z","timestamp":1432584225000},"page":"897-899","source":"Crossref","is-referenced-by-count":13,"title":["Xeroderma pigmentosum complementation group F: Report of a case and review of Japanese patients"],"prefix":"10.1111","volume":"42","author":[{"given":"Yukari","family":"Tofuku","sequence":"first","affiliation":[{"name":"Department of Dermatology The Jikei University School of Medicine Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshimasa","family":"Nobeyama","sequence":"additional","affiliation":[{"name":"Department of Dermatology The Jikei University School of Medicine Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ryoichi","family":"Kamide","sequence":"additional","affiliation":[{"name":"Hihuno Clinic Ningyocho Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shinichi","family":"Moriwaki","sequence":"additional","affiliation":[{"name":"Department of Dermatology The Osaka Medical College Osaka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hidemi","family":"Nakagawa","sequence":"additional","affiliation":[{"name":"Department of Dermatology The Jikei University School of Medicine Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,5,25]]},"reference":[{"key":"e_1_2_5_2_1","first-page":"1311","volume-title":"Fitzpatrick's dermatology in general medicine","author":"Wolff K","year":"2007"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/mutage\/13.6.595"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.285.5425.263"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2010.76"},{"key":"e_1_2_5_6_1","volume-title":"Xeroderma pigmentosum. Genereviews [internet]","author":"Kraemer KH","year":"2014"},{"key":"e_1_2_5_7_1","first-page":"79","article-title":"Recent progress in the diagnosis of xeroderma pigmentosum (in Japanese)","volume":"53","author":"Moriwaki S","year":"1999","journal-title":"Clin Dermatol"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.12523"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.1993.tb00154.x"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.2336\/nishinihonhifu.52.279"},{"key":"e_1_2_5_11_1","first-page":"424","article-title":"A case of young XPF with basal cell carcinoma (in Japanese)","volume":"105","author":"Ito T","year":"1995","journal-title":"Jpn J Dermatol"},{"key":"e_1_2_5_12_1","first-page":"883","article-title":"A case of xeroderma pigmentosum group F (in Japanese)","volume":"108","author":"Yasue T","year":"1998","journal-title":"Jpn J Dermatol"},{"key":"e_1_2_5_13_1","first-page":"301","article-title":"Anti\u2010CENP\u2010F antibody in a patient with xeroderma pigmentosum (in Japanese)","volume":"110","author":"Kato Y","year":"2000","journal-title":"Jpn J Dermatol"},{"key":"e_1_2_5_14_1","first-page":"866","article-title":"A case of xeroderma pigmentosum group F (in Japanese)","volume":"112","author":"Minamino Y","year":"2002","journal-title":"Jpn J Dermatol"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.2336\/nishinihonhifu.75.508"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/7.6.969"}],"container-title":["The Journal of Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2F1346-8138.12942","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1346-8138.12942","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,24]],"date-time":"2023-09-24T06:27:00Z","timestamp":1695536820000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/1346-8138.12942"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,5,25]]},"references-count":15,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2015,9]]}},"alternative-id":["10.1111\/1346-8138.12942"],"URL":"https:\/\/doi.org\/10.1111\/1346-8138.12942","archive":["Portico"],"relation":{},"ISSN":["0385-2407","1346-8138"],"issn-type":[{"value":"0385-2407","type":"print"},{"value":"1346-8138","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,5,25]]}}}